EXTRACELLULAR MATRIX PROTEINS IN ORGAN TRANSPLANTATION1

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Laminin–a glycoprotein from basement membranes.

1979 • 2,372 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant.

1994 • 1,190 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

Laminin and Other Basement Membrane Components

1987 • 900 citations

The molecular elasticity of the extracellular matrix protein tenascin

1998 • 835 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

A new nomenclature for the laminins

1994 • 753 citations

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.

1987 • 736 citations

Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.

1985 • 659 citations

Regulated expression and binding of three VLA (β1) integrin receptors on T cells

1990 • 634 citations

The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression.

1995 • 627 citations

The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function.

1994 • 617 citations

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 • 616 citations

Tenascin: An Extracellular Matrix Protein Prominent in Specialized Embryonic Tissues and Tumors

1989 • 604 citations

Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site

1997 • 560 citations

Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat.

1989 • 489 citations

Distribution of Fibronectin During Wound Healing in Vivo

1981 • 474 citations

The dynamic regulation of integrin adhesiveness

1994 • 456 citations

Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis.

1994 • 444 citations

Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.

1987 • 428 citations

CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway.

1996 • 421 citations

Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions

1993 • 401 citations

Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin.

1990 • 400 citations

Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo.

1998 • 368 citations

Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts.

1988 • 340 citations

A tumor-associated fibronectin isoform generated by alternative splicing of messenger RNA precursors.

1989 • 339 citations

A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1).

1990 • 300 citations

Regulation of fibronectin receptor distribution [published erratum appears in J Cell Biol 1992 Jul;118(2):491]

1992 • 295 citations

Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex.

1989 • 291 citations

The Dynamics of Proteins

1986 • 281 citations

Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin [published erratum appears in J Cell Biol 1992 Feb;116(3):833]

1991 • 281 citations

Differential expression of the ed sequence-containing form of cellular fibronectin in embryonic and adult human tissues

1987 • 251 citations

Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis.

1996 • 220 citations

Fibronectins

1986 • 209 citations

Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion.

1992 • 194 citations

The C–C Chemokine MCP-1 Differentially Modulates the Avidity of β1 and β2 Integrins on T Lymphocytes

1996 • 193 citations

Macrophages and fibroblasts express embryonic fibronectins during cutaneous wound healing.

1993 • 191 citations

Control of Integrin Expression by Extracellular Matrix

1995 • 190 citations

Interaction of Dendritic Cells with Skin Endothelium: A New Perspective on Immunosurveillance

1999 • 178 citations

A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon.

1984 • 169 citations

Tenascin, an extracellular matrix protein, exerts immunomodulatory activities.

1989 • 167 citations

Anti-CD4 abrogates rejection and reestablishes long-term tolerance to syngeneic newborn hearts grafted in mice chronically infected with Trypanosoma cruzi.

1992 • 162 citations

Fibronectin: from gene to protein

1991 • 161 citations

Specific roles of the αVβ1, αVβ3 and αVβ5 integrins in avian neural crest cell adhesion and migration on vitronectin

1994 • 161 citations

Characterization of the integrin alpha 8 subunit: a new integrin beta 1-associated subunit, which is prominently expressed on axons and on cells in contact with basal laminae in chick embryos.

1991 • 161 citations

Activation of human CD4 T lymphocytes. Interaction of fibronectin with VLA-5 receptor on CD4 cells induces the AP-1 transcription factor.

1991 • 154 citations

The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.

1996 • 147 citations

Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein.

1992 • 143 citations

Human B lymphocytes define an alternative mechanism of adhesion to fibronectin. The interaction of the alpha 4 beta 1 integrin with the LHGPEILDVPST sequence of the type III connecting segment is sufficient to promote cell attachment.

1990 • 132 citations

Rapid expression of fibronectin in the rabbit heart after myocardial infarction with and without reperfusion.

1992 • 128 citations

Alpha 4 beta 7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Expression and function of alpha 4 integrins on human B lymphocytes.

1993 • 128 citations

In vivo blockade of tumor necrosis factor-alpha in cholesterol-fed rabbits after cardiac transplant inhibits acute coronary artery neointimal formation.

1994 • 123 citations

Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.

1994 • 122 citations

Human neutrophil adherence to laminin in vitro. Evidence for a distinct neutrophil integrin receptor for laminin.

1990 • 122 citations

Type 2 helper T cell-type cytokines and the development of "infectious" tolerance in rat cardiac allograft recipients.

1997 • 119 citations

Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment.

1994 • 116 citations

A role for phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigen.

1995 • 111 citations

High-affinity binding of interferon-gamma to a basement membrane complex (matrigel).

1991 • 109 citations

Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1.

1994 • 107 citations

Fibronectin in delayed-type hypersensitivity skin reactions: associations with vessel permeability and endothelial cell activation.

1981 • 105 citations

Blockade of very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts.

1995 • 101 citations

TREATMENT WITH ANTI-VASCULAR CELL ADHESION MOLECULE 1 MONOCLONAL ANTIBODY INDUCES LONG-TERM MURINE CARDIAC ALLOGRAFT ACCEPTANCE

1993 • 99 citations

The α5β1 Integrin Mediates Elimination of Amyloid-β Peptide and Protects Against Apoptosis

1998 • 97 citations

Synthetic fibronectin peptides interrupt inflammatory cell infiltration in transforming growth factor beta 1 knockout mice.

1994 • 96 citations

Activation of the alpha 4 beta 1 integrin through the beta 1 subunit induces recognition of the RGDS sequence in fibronectin.

1994 • 96 citations

Inhibition of T cell activation by the extracellular matrix protein tenascin.

1994 • 71 citations

Tenascin Supports Lymphocyte Rolling

1997 • 70 citations

Fibronectin Type III5 Repeat Contains a Novel Cell Adhesion Sequence, KLDAPT, Which Binds Activated α4β1 and α4β7 Integrins

1997 • 67 citations

Fibronectin expression in the normal and hypertrophic rat heart.

1992 • 67 citations

Functional specialization of fibronectin-binding beta 1-integrins in T lymphocyte migration.

1994 • 65 citations

CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation-dependent activation of phosphatidylinositol 3-kinase.

1997 • 63 citations

Recognition of self within self: specific lymphocyte positioning and the extracellular matrix

1991 • 63 citations

Tolerance induction ameliorates allograft vasculopathy in rat aortic transplants. Influence of Fas-mediated apoptosis.

1998 • 61 citations

APOPTOTIC CELL DEATH IN HUMAN CHRONIC RENAL ALLOGRAFT REJECTION

1997 • 61 citations

Tenascin-C inhibits β1 integrin-dependent T lymphocyte adhesion to fibronectin through the binding of its fnIII 1 – 5 repeats to fibronectin

1999 • 60 citations

The leukocyte β1 integrins

1995 • 58 citations

APOPTOSIS IN MURINE CARDIAC GRAFTS1,2,3

1997 • 58 citations

Unique changes in interstitial extracellular matrix composition are associated with rejection and cyclosporine toxicity in human renal allograft biopsies

1999 • 57 citations

Mechanisms of Fibronectin and Integrin Function during Cell Adhesion and Migration

1992 • 57 citations

Anti-TNF-alpha treatment down-regulates the expression of fibronectin and decreases cellular infiltration of cardiac allografts in rats.

1995 • 57 citations

PROLONGATION OF RAT ISLET ALLOGRAFT SURVIVAL BY TREATMENT WITH MONOCLONAL ANTIBODIES AGAINST VLA-4 AND LFA-1

1995 • 55 citations

EA-1, a novel adhesion molecule involved in the homing of progenitor T lymphocytes to the thymus.

1991 • 54 citations

Integrin signaling in leukocytes: lessons from the α6β1 integrin

1997 • 54 citations

Expression of alternatively spliced fibronectin variants during remodeling in proliferative glomerulonephritis.

1995 • 54 citations

Cytokine and alloantibody networks in long term cardiac allografts in rat recipients treated with rapamycin.

1996 • 52 citations

Increased interleukin-1 beta and fibronectin expression are early features of the development of the postcardiac transplant coronary arteriopathy in piglets.

1993 • 51 citations

Reciprocal induction of tumor necrosis factor‐α and interleukin‐β activity mediates fibronectin synthesis in coronary artery smooth muscle cells

1995 • 51 citations

Plasmin-induced proteolysis of tenascin-C: modulation by T lymphocyte-derived urokinase-type plasminogen activator and effect on T lymphocyte adhesion, activation, and cell clustering.

1997 • 50 citations

Interferon-gamma C-terminal function: new working hypothesis. Heparan sulfate and heparin, new targets for IFN-gamma, protect, relax the cytokine and regulate its activity.

1991 • 49 citations

Constitutive expression of tenascin in T-dependent zones of human lymphoid tissues.

1993 • 48 citations

FIBROSIS IN CHRONIC REJECTION OF HUMAN LIVER ALLOGRAFTS

1996 • 48 citations

ABROGATION BY RAPAMYCIN OF ACCELERATED REJECTION IN SENSITIZED RATS BY INHIBITION OF ALLOANTIBODY RESPONSES AND SELECTIVE SUPPRESSION OF INTRAGRAFT MONONUCLEAR AND ENDOTHELIAL CELL ACTIVATION, CYTOKINE PRODUCTION, AND CELL ADHESION1,2

1994 • 47 citations

Contribution of lymphocyte function-associated-1/intercellular adhesion molecule-1 binding to the adhesion/signaling cascade of cytotoxic T lymphocyte activation.

1994 • 46 citations

Role of alpha 5 beta 1 integrin in TGF-beta 1-costimulated CD8+ T cell growth and apoptosis.

1996 • 45 citations

Extracellular matrix components of the mouse thymic microenvironment. III. Thymic epithelial cells express the VLA6 complex that is involved in laminin-mediated interactions with thymocytes

1993 • 45 citations

Expression of fibronectin splicing variants in organ transplantation: a differential pattern between rat cardiac allografts and isografts.

1997 • 44 citations

THE EXPRESSION OF EXTRACELLULAR MATRIX PROTEINS DURING ACCELERATED REJECTION OF CARDIAC ALLOGRAFTS IN SENSITIZED RATS

1994 • 43 citations

Rapamycin treatment depresses intragraft expression of KC/MIP-2, granzyme B, and IFN-gamma in rat recipients of cardiac allografts.

1993 • 41 citations

Distribution of integrins on human peripheral blood mononuclear cells

1989 • 41 citations

Alpha 4 beta 1 integrin-mediated tyrosine phosphorylation in human T cells: characterization of Crk- and Fyn-associated substrates (pp105, pp115, and human enhancer of filamentation-1) and integrin-dependent activation of p59fyn1.

1997 • 40 citations

THE EXPRESSION OF EXTRACELLULAR MATRIX PROTEINS DURING ACCELERATED REJECTION OF CARDIAC ALLOGRAFTS IN SENSITIZED RATS

1994 • 39 citations

Lymphocyte traffic is modified in vivo by anti-laminin antibody.

1991 • 37 citations

BLOCKADE OF VERY LATE ANTIGEN-4 INTEGRIN BINDING TO FIBRONECTIN IN ALLOGRAFT RECIPIENTS

1998 • 35 citations

T lymphocyte adhesion to fibronectin (FN): a possible mechanism for T cell accumulation in the rheumatoid joint

1992 • 34 citations

BLOCKADE OF VERY LATE ANTIGEN-4 INTEGRIN BINDING TO FIBRONECTIN IN ALLOGRAFT RECIPIENTS

1998 • 33 citations

Extracellular matrix induces tumour necrosis factor-alpha secretion by an interaction between resting rat CD4+ T cells and macrophages.

1993 • 33 citations

Embryonic fibronectin isoforms are synthesized in crescents in experimental autoimmune glomerulonephritis.

1995 • 29 citations

Involvement of laminin and its receptor in abrogation of heart graft rejection by autoreactive T cells from Trypanosoma cruzi-infected mice.

1997 • 26 citations

Human monocyte binding to fibronectin enhances IFN-gamma-induced early signaling events.

1997 • 26 citations

Fibronectin induces phosphorylation of a 120‐kDa protein and synergizes with the T cell receptor to activate cytotoxic T cell clones

1995 • 26 citations

Augmentation of mature CD4+ T cell responses to isolated antigenic class II proteins by fibronectin and intercellular adhesion molecule-1.

1997 • 25 citations

IMMUNOMODULATORY FUNCTIONS OF HYALURONATE IN THE LEW-TO-F344 MODEL OF CHRONIC CARDIAC ALLOGRAFT REJECTION

1999 • 22 citations

Differential Th1 and Th2 cell regulation of murine cardiac allograft acceptance by blocking cell adhesion of ICAM-1/LFA-1 and VCAM-1/VLA-4

1999 • 21 citations

DOWN-MODULATION OF HOST REACTIVITY BY ANTI-CD44 IN SKIN TRANSPLANTATION1

1998 • 20 citations

Comitogenic effects of very late activation antigens on CD3-stimulated human thymocytes. Involvement of various tyrosine kinase pathways.

1995 • 19 citations

The Role of Cellular and Extracellular Matrix Adhesion Proteins in Organ Transplantation

1994 • 12 citations

Lymphocyte Traffic and Positioning in Vivo: An Expande Role for the ECM, the VLA Proteins and the Cytokines

1994 • 12 citations

Extracellular matrix proteins: bystanders or active participants in the allograft rejection cascade?

1996 • 12 citations

Abnormal T-cell costimulation by proteins of the extracellular matrix in human renal allografting

1993 • 7 citations

Changes at the extracellular matrix during acute and chronic rejection in human liver transplantation

1998 • 7 citations

Different roles for α4-integrin/VCAM-1 and α4/fibronectin interactions in allograft rejection

1999 • 2 citations