Reprogramming the immune system

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

‘Actively Acquired Tolerance’ of Foreign Cells

1953 • 3,103 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Regulatory T Cells

2000 • 1,827 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Reshaping human antibodies for therapy

1988 • 1,555 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

"Infectious" Transplantation Tolerance

1993 • 890 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

Infectious immunological tolerance.

1971 • 811 citations

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

2001 • 799 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

Specific Acceptance of Cardiac Allograft After Treatment with Antibodies to ICAM-1 and LFA-1

1992 • 737 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies.

1987 • 615 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

Cytotoxic T Lymphocyte Antigen-4 Accumulation in the Immunological Synapse Is Regulated by TCR Signal Strength

2002 • 497 citations

Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis

1999 • 467 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

ELIMINATION OF GRAFT-VERSUS-HOST DISEASE BY IN-VITRO DEPLETION OF ALLOREACTIVE LYMPHOCYTES WITH A MONOCLONAL RAT ANTI-HUMAN LYMPHOCYTE ANTIBODY (CAMPATH-1)

1984 • 436 citations

Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis

1999 • 426 citations

Rat × rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG

1979 • 411 citations

Mixed Chimerism and Transplant Tolerance

2001 • 391 citations

Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance

2002 • 372 citations

Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement

1983 • 365 citations

Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype

1989 • 356 citations

Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance

1986 • 344 citations

CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations

2000 • 334 citations

Induction of classical transplantation tolerance in the adult.

1989 • 325 citations

Induction of tolerance by monoclonal antibody therapy

1986 • 307 citations

CAMPATH IH ALLOWS LOW-DOSE CYCLOSPORINE MONOTHERAPY IN 31 CADAVERIC RENAL ALLOGRAFT RECIPIENTS

1999 • 306 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 303 citations

Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4.

1998 • 297 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 294 citations

Induction of tolerance in peripheral T cells with monoclonal antibodies

1990 • 285 citations

In vitro tolerance induction of neonatal murine B cells.

1976 • 281 citations

CD40 Ligand Blockade Induces CD4+ T Cell Tolerance and Linked Suppression

1999 • 251 citations

T cell suppression in transplantation tolerance through linked recognition.

1996 • 246 citations

Regulating the Immune Response to Transplants

2001 • 242 citations

Activation of mouse complement by monoclonal mouse antibodies

1981 • 226 citations

HOW DO MONOCLONAL ANTIBODIES INDUCE TOLERANCE? A Role for Infectious Tolerance?

1998 • 223 citations

Improving the Outcome of Bone Marrow Transplantation by Using CD52 Monoclonal Antibodies to Prevent Graft-Versus-Host Disease and Graft Rejection

1998 • 207 citations

Long-term remission of intractable systemic vasculitis with monoclonal antibody therapy

1993 • 205 citations

Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation Tolerance

2000 • 202 citations

Cellular Sites of Immunologic Unresponsiveness

1970 • 202 citations

Mechanisms of Peripheral Tolerance and Suppression Induced by Monoclonal Antibodies to CD4 and CD8

1996 • 195 citations

Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts

2002 • 180 citations

The immunogenicity of chimeric antibodies.

1989 • 176 citations

Linked suppression of skin graft rejection can operate through indirect recognition.

1998 • 175 citations

CD4 monoclonal antibody pairs for immunosuppression and tolerance induction

1987 • 173 citations

Mechanisms in CD4 antibody‐mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells

1994 • 167 citations

CD52 antibodies for prevention of graft-versus-host disease and graft rejection following transplantation of allogeneic peripheral blood stem cells

2000 • 167 citations

Tolerance to rat monoclonal antibodies. Implications for serotherapy.

1986 • 161 citations

AMPLIFICATION OF NATURAL REGULATORY IMMUNE MECHANISMS FOR TRANSPLANTATION TOLERANCE1

1996 • 161 citations

The induction of skin graft tolerance in major histocompatibility complex‐mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti‐CD4 and anti‐CD8 antibodies

1990 • 157 citations

Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes.

1985 • 147 citations

Rejection of H-Y Disparate Skin Grafts by Monospecific CD4+ Th1 and Th2 Cells: No Requirement for CD8+ T Cells or B Cells

1998 • 146 citations

A repertoire of monoclonal antibodies with human heavy chains from transgenic mice.

1989 • 145 citations

T cell regulation in adult transplantation tolerance.

1996 • 144 citations

Cutting Edge: Linked Suppression of Skin Graft Rejection Can Operate Through Indirect Recognition

1998 • 138 citations

Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.

1997 • 129 citations

Tolerance in the mouse to major histocompatibility complex‐mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8

1992 • 128 citations

Induction of immune tolerance by administration of monoclonal antibody to L3T4.

1986 • 127 citations

Ex vivo coating of islet cell allografts with murine CTLA4/Fc promotes graft tolerance.

1995 • 126 citations

Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients.

1996 • 126 citations

Reprogramming the Immune System for Peripheral Tolerance with CD4 and CD8 Monoclonal Antibodies

1992 • 124 citations

The role of CD4⁺ T‐cell subsets in determining transplantation rejection or tolerance

2001 • 120 citations

Mechanisms of monoclonal antibody‐facilitated tolerance induction: a possible role for the CD4 (L3T4) and CD11a (LFA‐1) molecules in self‐non‐self discrimination

1988 • 116 citations

The in vivo mechanism of action of CTLA4Ig.

1996 • 106 citations

The Depletion of T Cell Subsets in Vitro and in Vivo

1986 • 105 citations

Bone Marrow Transplantation Induces Either Clonal Deletion or Infectious Tolerance Depending on the Dose

1998 • 101 citations

Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment.

1997 • 98 citations

What is the role of regulatory T cells in transplantation tolerance?

1999 • 98 citations

Repertoire Requirements of CD4+ T Cells That Prevent Spontaneous Autoimmune Encephalomyelitis

2000 • 97 citations

Targeting Signal 1 Through CD45RB Synergizes with CD40 Ligand Blockade and Promotes Long Term Engraftment and Tolerance in Stringent Transplant Models

2001 • 95 citations

Treatment of murine lupus with F(ab')2 fragments of monoclonal antibody to L3T4. Suppression of autoimmunity does not depend on T helper cell depletion.

1989 • 88 citations

TOLERANCE AND SUPPRESSION IN A PRIMED IMMUNE SYSTEM1

1996 • 87 citations

Induction of immune tolerance during administration of monoclonal antibody to L3T4 does not depend on depletion of L3T4+ cells.

1988 • 84 citations

Immunoglobulin heavy chain locus of the rat: striking homology to mouse antibody genes.

1986 • 79 citations

Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice

2002 • 79 citations

CD4+ CD45RB Low-Density Cells from Untreated Mice Prevent Acute Allograft Rejection

1999 • 75 citations

Isolation of low-frequency class-switch variants from rat hybrid myelomás

1987 • 67 citations

Elimination of the Immunogenicity of Therapeutic Antibodies

1999 • 67 citations

Classical transplantation tolerance in the adult: the interaction between myeloablation and immunosuppression

1992 • 59 citations

Combined anti-CD2 and anti-CD3 receptor monoclonal antibodies induce donor-specific tolerance in a cardiac transplant model.

1993 • 57 citations

CD4-positive suppressor cells block allotransplant rejection.

1995 • 53 citations

IMMUNOLOGICAL TOLERANCE IN BONE MARROW-DERIVED LYMPHOCYTES

1974 • 50 citations

Monoclonal antibodies as agents to reinducetolerance in autoimmunity

1992 • 49 citations

Molecular Mechanisms of Immunological Self-Recognition

1993 • 43 citations

Expression of spleen cell immunoglobulin phenotype in hybrids with myeloma cell lines

1981 • 35 citations

ACCEPTANCE OF PRIMARY SKIN GRAFT AFTER TREATMENT WITH ANTI-INTERCELLULAR ADHESION MOLECULE-1 AND ANTI-LEUKOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 MONOCLONAL ANTIBODIES IN MICE

1996 • 32 citations

Mechanisms of Induction of Tolerance to Organ Allografts

2000 • 28 citations

COEXISTENCE OF TH1- AND TH2-TYPE CYTOKINE PROFILES IN ANTI-CD2 MONOCLONAL ANTIBODY-INDUCED TOLERANCE1

1996 • 28 citations

Antilymphocyte serum, donor bone marrow and tolerance to allografts: the journey is the reward

1999 • 17 citations

Interaction of Rat Monoclonal Antibodies with Human Killer Cells

1985 • 5 citations