Thrombopoietin and the Hematopoietic Stem Cell

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

1994 • 1,081 citations

Stem Cell Factor and Hematopoiesis

1997 • 850 citations

Thrombopoietin: the primary regulator of platelet production [see comments]

1995 • 691 citations

The transcriptional control of hematopoiesis [see comments]

1996 • 608 citations

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

1995 • 596 citations

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

1996 • 589 citations

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.

1992 • 525 citations

Extensive Amplification and Self-Renewal of Human Primitive Hematopoietic Stem Cells From Cord Blood

1997 • 464 citations

A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors

1990 • 404 citations

Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin

1998 • 389 citations

The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells

1996 • 364 citations

Role of c-mpl in Early Hematopoiesis

1998 • 362 citations

Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin.

1996 • 360 citations

Ex vivo expansion of murine marrow cells with interleukin-3 (IL-3), IL- 6, IL-11, and stem cell factor leads to impaired engraftment in irradiated hosts

1996 • 326 citations

Low levels of erythroid and myeloid progenitors in thrombopoietin-and c- mpl-deficient mice

1996 • 287 citations

Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice

1996 • 278 citations

Expansionin vitroof adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability

1997 • 276 citations

Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy.

1995 • 269 citations

In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells

1994 • 268 citations

Ultrastructure of Platelet Formation by Human Megakaryocytes Cultured With the Mpl Ligand

1997 • 196 citations

Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia.

1996 • 192 citations

Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice.

1996 • 171 citations

Adult Mice With Targeted Mutation of the Interleukin-11 Receptor (IL11Ra) Display Normal Hematopoiesis

1997 • 167 citations

Bone marrow transplantation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential

1993 • 166 citations

In Vitro Expansion of Hematopoietic Progenitors and Maintenance of Stem Cells: Comparison Between FLT3/FLK-2 Ligand and KIT Ligand

1997 • 155 citations

Marrow- and spleen-seeding efficiencies of all murine hematopoietic stem cell subsets are decreased by preincubation with hematopoietic growth factors

1995 • 148 citations

Stem cell factor enhances the survival but not the self-renewal of murine hematopoietic long-term repopulating cells

1994 • 137 citations

In vivo administration of stem cell factor to mice increases the absolute number of pluripotent hematopoietic stem cells

1993 • 121 citations

Maintenance of murine long-term repopulating stem cells in ex vivo culture is affected by modulation of transforming growth factor-beta but not macrophage inflammatory protein-1 alpha activities

1996 • 76 citations

Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy‐induced thrombocytopenia

1996 • 54 citations

Hematopoietic growth factors in acute leukemia

1997 • 48 citations

Prevention of Thrombocytopenia by Thrombopoietin in Myelosuppressed Rhesus Monkeys Accompanied by Prominent Erythropoietic Stimulation and Iron Depletion

1997 • 48 citations

Modulation of apoptosis in human myeloid leukemic cells by GM-CSF.

1995 • 28 citations