Rac1-dependent actin filament organization in growth cones is necessary for ?1-integrin-mediated advance but not for growth on poly-D-lysine

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids

1984 • 3,959 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

A simplified ultrasensitive silver stain for detecting proteins in polyacrylamide gels

1980 • 3,334 citations

The Molecular Biology of Axon Guidance

1996 • 3,246 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

1994 • 985 citations

Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function

1995 • 900 citations

Microinjection of recombinant p21rho induces rapid changes in cell morphology.

1990 • 720 citations

Neurite extension by peripheral and central nervous system neurons in response to substratum-bound fibronectin and laminin

1983 • 672 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones.

1986 • 526 citations

A Protein Induced During Nerve Growth (GAP-43) is a Major Component of Growth-Cone Membranes

1986 • 505 citations

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines

1996 • 454 citations

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases.

1995 • 410 citations

Rac1 Mediates Collapsin-1-Induced Growth Cone Collapse

1997 • 384 citations

Disoriented pathfinding by pioneer neurone growth cones deprived of filopodia by cytochalasin treatment

1986 • 378 citations

Growth cone advance is inversely proportional to retrograde F-actin flow

1995 • 371 citations

Growth of neurites without filopodial or lamellipodial activity in the presence of cytochalasin B.

1984 • 352 citations

Making the connection: Cytoskeletal rearrangements during growth cone guidance

1995 • 343 citations

RAS proteins can induce meiosis in xenopus oocytes

1985 • 341 citations

Nerve growth cone lamellipodia contain two populations of actin filaments that differ in organization and polarity.

1992 • 305 citations

A filter paper dye-binding assay for quantitative determination of protein without interference from reducing agents or detergents

1990 • 266 citations

Navigational errors made by growth cones without filopodia in the embryonic xenopus brain

1993 • 264 citations

Nerve growth cones isolated from fetal rat brain: Subcellular fractionation and characterization

1983 • 263 citations

The effect of Mg2+ on the guanine nucleotide exchange rate of p21N-ras.

1986 • 203 citations

c-src gene product in developing rat brain is enriched in nerve growth cone membranes.

1988 • 193 citations

ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons

1989 • 192 citations

Rho family small GTP-binding proteins in growth cone signalling

1997 • 190 citations

[1] Purification of recombinant Rho/Rac/G25K from Escherichia coli

1995 • 190 citations

Distribution and cellular localization of actin depolymerizing factor.

1987 • 187 citations

Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene

1990 • 174 citations

rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids.

1992 • 136 citations

Actin filament bundles are required for microtubule reorientation during growth cone turning to avoid an inhibitory guidance cue

1996 • 109 citations

Expression ofTiam-1in the Developing Brain Suggests a Role for the Tiam-1–Rac Signaling Pathway in Cell Migration and Neurite Outgrowth

1997 • 95 citations

Regulated plasmalemmal expansion in nerve growth cones.

1991 • 87 citations

Chick sensory neuronal growth cones distinguish fibronectin from laminin by making substratum contacts that resemble focal contacts

1996 • 85 citations

Focal Adhesion Kinase in Rat Central Nervous System

1995 • 82 citations

Rac is required for growth cone function but not neurite assembly

1997 • 75 citations

Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain

1993 • 70 citations

Gelsolin is localized in neuronal growth cones

1993 • 54 citations

Src, ras, and rac mediate the migratory response elicited by NGF and PMA in PC12 cells

1996 • 50 citations

Small GTPases in axon outgrowth.

1996 • 44 citations

Isolation and culture of motoneurons from embryonic chicken spinal cords.

1979 • 40 citations

An Inward Rectifier K+ Current Modulates in Neuroblastoma Cells the Tyrosine Phosphorylation of the pp125FAK and Associated Proteins: Role in Neuritogenesis

1995 • 28 citations

Identification of cytoskeletal, focal adhesion, and cell adhesion proteins in growth cone particles isolated from developing chick brain

1991 • 25 citations

Location of profilin at presynaptic sites in the cerebellar cortex; implication for the regulation of the actin-polymerization state during axonal elongation and synaptogenesis

1993 • 23 citations

Vinculin is one of the major endogenous substrates for intrinsic tyrosine kinases in neuronal growth cones isolated from fetal rat brain

1990 • 22 citations