The role of thrombin's Tyr-Pro-Pro-Trp motif in the interaction with fibrinogen, thrombomodulin, protein C, antithrombin III, and the Kunitz inhibitors.

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Protein Inhibitors of Proteinases

1980 • 2,220 citations

The coagulation cascade: initiation, maintenance, and regulation

1991 • 1,810 citations

Proteases and biological control

1976 • 1,380 citations

The Purification and Mechanism of Action of Human Antithrombin-Heparin Cofactor

1973 • 1,363 citations

The molecular basis of blood coagulation

1988 • 1,240 citations

The Roles of Protein C and Thrombomodulin in the Regulation of Blood Coagulation

1989 • 1,059 citations

Natural protein proteinase inhibitors and their interaction with proteinases

1992 • 1,048 citations

Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpins

1989 • 898 citations

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.

1989 • 889 citations

Factor XI Activation in a Revised Model of Blood Coagulation

1991 • 774 citations

The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin

1990 • 718 citations

The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human α‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationships

1992 • 628 citations

Kinetics of the inhibition of thrombin by hirudin

1986 • 581 citations

COFACTOR PROTEINS IN THE ASSEMBLY AND EXPRESSION OF BLOOD CLOTTING ENZYME COMPLEXES

1988 • 535 citations

Anticoagulant properties of bovine plasma protein C following activation by thrombin

1977 • 495 citations

Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition.

1990 • 362 citations

Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.

1991 • 278 citations

Structure of the hirugen and hirulog 1 complexes of α-thrombin

1991 • 268 citations

The interaction of thrombin with fibrinogen

1992 • 216 citations

Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C.

1983 • 202 citations

Characterization of human blood coagulation factor XII cDNA. Prediction of the primary structure of factor XII and the tertiary structure of beta-factor XIIa.

1985 • 194 citations

Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin

1988 • 170 citations

Proclotting enzyme from horseshoe crab hemocytes. cDNA cloning, disulfide locations, and subcellular localization.

1990 • 164 citations

Isolation, characterization, and cDNA cloning of a vampire bat salivary plasminogen activator

1989 • 164 citations

Steady state kinetic parameters for the thrombin-catalyzed conversion of human fibrinogen to fibrin.

1983 • 154 citations

Effect of thrombomodulin on the kinetics of the interaction of thrombin with substrates and inhibitors

1986 • 154 citations

Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin.

1991 • 141 citations

Nucleotide sequence of the cDNA coding for human complement C1r

1986 • 140 citations

Characterization of a complementary deoxyribonucleic acid coding for the .gamma. chain of human fibrinogen

1983 • 132 citations

Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin.

1991 • 129 citations

The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.

1992 • 127 citations

Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the .beta. chain of human fibrinogen

1983 • 126 citations

Identification of regions of .alpha.-thrombin involved in its interaction with hirudin

1987 • 122 citations

An ordered addition, essential activation model of the tissue factor pathway of coagulation: evidence for a conformational cage

1986 • 121 citations

[27] Factor XIII (fibrin-stabilizing factor)

1981 • 117 citations

Conversion of antithrombin from an inhibitor of thrombin to a substrate with reduced heparin affinity and enhanced conformational stability by binding of a tetradecapeptide corresponding to the P1 to P14 region of the putative reactive bond loop of the inhibitor.

1992 • 115 citations

THE STRUCTURE AND EVOLUTION OF VERTEBRATE FIBRINOGEN

1983 • 107 citations

The fifth and sixth growth factor-like domains of thrombomodulin bind to the anion-binding exosite of thrombin and alter its specificity.

1992 • 97 citations

[3] Determination of proteolytic activities on casein substrates

1976 • 91 citations

Thrombin Glu-39 restricts the P'3 specificity to nonacidic residues

1991 • 90 citations

Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogs

1990 • 88 citations

Electrostatic interactions in the association of proteins: An analysis of the thrombin–hirudin complex

1992 • 87 citations

Characterization of a complementary deoxyribonucleic acid coding for the .alpha. chain of human fibrinogen

1983 • 87 citations

Enzymic properties of proteolytic derivatives of human .alpha.-thrombin

1988 • 85 citations

High-resolution NMR studies of fibrinogen-like peptides in solution: structure of a thrombin-bound peptide corresponding to residues 7-16 of the A.alpha. chain of human fibrinogen

1989 • 79 citations

Partial characterization of vertebrate prothrombin cDNAs: amplification and sequence analysis of the B chain of thrombin from nine different species.

1992 • 75 citations

Physical evidence for an apolar binding site near the catalytic center of human α-thrombin

1977 • 73 citations

High-resolution NMR studies of fibrinogen-like peptides in solution: interaction of thrombin with residues 1-23 of the A.alpha. chain of human fibrinogen

1989 • 73 citations

Role of thrombin exosites in inhibition by heparin cofactor II.

1992 • 72 citations

FACTORS INFLUENCING FIBRIN GEL STRUCTURE STUDIED BY FLOW MEASUREMENT*

1983 • 70 citations

Interactions of factor XIII with fibrin as substrate and cofactor

1992 • 65 citations

Interaction of thrombin des-ETW with antithrombin III, the Kunitz inhibitors, thrombomodulin and protein C. Structural link between the autolysis loop and the Tyr-Pro-Pro-Trp insertion of thrombin.

1992 • 63 citations

Activation of Blood Coagulation Factor XIII^a

1986 • 57 citations

Proteins in Biology and Medicine

1982 • 50 citations

Enhancing protein C interaction with thrombin results in a clot-activated anticoagulant

1992 • 49 citations

Recombinant human protein C derivatives: altered response to calcium resulting in enhanced activation by thrombin.

1990 • 48 citations

Role of interactions involving C-terminal nonpolar residues of hirudin in the formation of the thrombin-hirudin complex

1991 • 44 citations

Ionic interactions in the formation of the thrombin-hirudin complex

1991 • 42 citations

The role of calcium ions in factor X activation by thrombin E192Q.

1992 • 40 citations

The effect of thrombomodulin on the cleavage of fibrinogen and fibrinogen fragments by thrombin

1987 • 33 citations

Thrombin: Active‐Site Topography^a

1986 • 29 citations

Binding of the bovine basic pancreatic trypsin inhibitor (Kunitz) to human α-, β- and γ-thrombin; a kinetic and thermodynamic study

1988 • 28 citations

Basis for the reduced affinity of .beta.T- and .gamma.T-thrombin for hirudin

1991 • 25 citations

Specificity of Thrombin and Its Action on Fibrinogen

1986 • 16 citations

Irreversible inactivation of β-lactamase I from Bacillus cereus by chlorinated 6-spiroepoxypenicillins

1991 • 12 citations

Disulfide-linked cyanogen bromide peptides of bovine fibrinogen II. Isolation and sequence analysis of the chain constituents from the amino terminal region

1977 • 11 citations