Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.

Improved Fourier coefficients for maps using phases from partial structures with errors

1986 • 1,897 citations

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

Evaluation of single-crystal X-ray diffraction data from a position-sensitive detector

1988 • 1,516 citations

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.

1989 • 889 citations

The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin

1990 • 718 citations

Structure of Complex of Synthetic HIV-1 Protease with a Substrate-Based Inhibitor at 2.3 Å Resolution

1989 • 683 citations

Human thrombins. Production, evaluation, and properties of alpha-thrombin.

1977 • 587 citations

The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors

1983 • 580 citations

Design, Activity, and 2.8 Å Crystal Structure of a C ₂ Symmetric Inhibitor Complexed to HIV-1 Protease

1990 • 524 citations

Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition.

1990 • 362 citations

Protein crystallization using incomplete factorial experiments.

1979 • 336 citations

D-PHE-PRO-ARGCH2Cl-A selective affinity label for thrombin

1979 • 327 citations

Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl]-2-piperidinecarboxylic acid

1984 • 313 citations

Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl-pepstatin at 2.0-A resolution.

1990 • 247 citations

Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereo-structure of its hydrophobic carboxamide portion

1981 • 245 citations

Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.

1989 • 231 citations

Chemistry and biology of thrombin

1978 • 198 citations

Geometry of binding of the benzamidine‐ and arginine‐based inhibitors N^α‐(2‐naphthyl‐sulphonyl‐glycyl)‐<scp>dl</scp>‐p‐amidinophenylalanyl‐piperidine (NAPAP) and (2R,4R)‐4‐methyl‐1‐[N^α‐(3‐methyl‐1,2,3,4‐tetrahydro‐8‐quinolinesulphonyl)‐<scp>l</scp>‐arginyl]‐2‐piperidine carboxylic acid (MQPA) to human α‐thrombin

1990 • 123 citations

Cyclic amides of Nα-arylsulfonylaminoacylated 4-amidinophenylalanine - tight binding inhibitors of thrombin

1983 • 113 citations

High-resolution NMR studies of fibrinogen-like peptides in solution: structure of a thrombin-bound peptide corresponding to residues 7-16 of the A.alpha. chain of human fibrinogen

1989 • 79 citations

High-resolution NMR studies of fibrinogen-like peptides in solution: interaction of thrombin with residues 1-23 of the A.alpha. chain of human fibrinogen

1989 • 73 citations

Distinct binding sites of Ala48-hirudin1-47 and Ala48-hirudin48-65 on alpha-thrombin.

1990 • 53 citations

Thrombin inhibitors. 3. Carboxyl-containing amide derivatives of N.alpha.-substituted L-arginine

1980 • 51 citations

High-resolution NMR studies of fibrinogen-like peptides in solution: structural basis for the bleeding disorder caused by a single mutation of Gly(12) to Val(12) in the A.alpha. chain of human fibrinogen Rouen

1989 • 51 citations

Thrombin inhibitors. 1. Ester derivatives of N.alpha.-(arylsulfonyl)-L-arginine

1980 • 50 citations

Thrombin inhibitors. 2. Amide derivatives of N.alpha.-substituted L-arginine

1980 • 50 citations

Generic shapes for the conformation analysis of macrocyclic structures

1988 • 48 citations

X-Ray Analysis of a Thrombin Inhibitor-Trypsin Complex1

1989 • 31 citations

N-Terminal requirements of small peptide anticoagulants based on hirudin 54-65

1988 • 18 citations

A Predicted Tertiary Structure of a Thrombin Inhibitor-Trypsin Complex Explains the Mechanisms of the Selective Inhibition of Thrombin, Factor Xa, Plasmin, and Trypsin1

1988 • 14 citations