Synthesis and Biological Activity of Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2-Aryl-Substituted Benzimidazoles

Toward Improved Anti-HIV Chemotherapy: Therapeutic Strategies for Intervention with HIV Infections

1995 • 699 citations

New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Synthetic and Natural Products for AIDS-Antiviral Activity

1989 • 689 citations

Locations of Anti-AIDS Drug Binding Sites and Resistance Mutations in the Three-dimensional Structure of HIV-1 Reverse Transcriptase

1994 • 512 citations

THE BIOCHEMISTRY OF AIDS

1991 • 332 citations

Expression of soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants.

1988 • 228 citations

HIV resistance to reverse transcriptase inhibitors

1994 • 225 citations

Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.

1993 • 189 citations

HIV‐1‐specific RT inhibitors: Highly selective inhibitors of human immunodeficiency virus type 1 that are specifically targeted at the viral reverse transcriptase

1993 • 166 citations

Review of HIV-1 reverse transcriptase three-dimensional structure: Implications for drug design

1993 • 131 citations

Diarylsulfones, a new chemical class of nonnucleoside antiviral inhibitors of human immunodeficiency virus type 1 reverse transcriptase

1993 • 127 citations

Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase

1993 • 118 citations

Thiazolobenzimidazole: Biological and biochemical anti-retroviral activity of a new nonnucleoside reverse transcriptase inhibitor

1993 • 88 citations

Comparative anti-HIV evaluation of diverse HIV-1-specific reverse transcriptase inhibitor-resistant virus isolates demonstrates the existence of distinct phenotypic subgroups

1995 • 61 citations

Competitive inhibitors of human immunodeficiency virus reverse transcriptase

1993 • 48 citations

Non-nucleoside inhibitors of HIV-1 reverse transcriptase

1993 • 44 citations

Identification of a eukaryotic‐like protein kinase gene in Archaebacteria

1995 • 32 citations

Synthesis of substituted thietanes and thiolanes from α- and β-chloroepoxides and their oxidation to 1,1-dioxides

1978 • 17 citations