CD28 Regulates the Translation of Bcl-xL via the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Pathway

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

1999 • 2,096 citations

TOR, a Central Controller of Cell Growth

2000 • 1,919 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

The CD28 Signaling Pathway Regulates Glucose Metabolism

2002 • 1,331 citations

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

2004 • 1,226 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

2001 • 1,012 citations

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

1999 • 997 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice

2002 • 910 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

T-cell regulation by CD28 and CTLA-4

2001 • 857 citations

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

2002 • 812 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

2002 • 654 citations

PKB/AKT: functional insights from genetic models

2001 • 611 citations

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

2000 • 587 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

A NEW ANALYSIS OF ALLOGENEIC INTERACTIONS

1975 • 551 citations

The PI3K‒PDK1 connection: more than just a road to PKB

2000 • 503 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

Stabilization of Interleukin-2 mRNA by the c-Jun NH ₂ -Terminal Kinase Pathway

1998 • 353 citations

Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation

2000 • 345 citations

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

2000 • 339 citations

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

2002 • 334 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

1994 • 291 citations

eIF4E activity is regulated at multiple levels

1999 • 287 citations

Phosphatidylinositol 3-Kinase/Akt Activity Regulates c-FLIP Expression in Tumor Cells

2001 • 279 citations

CD28 costimulation prevents cell death during primary T cell activation.

1996 • 270 citations

Translational control: the cancer connection

1999 • 222 citations

CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation.

1996 • 220 citations

A point mutation in CD28 distinguishes proliferative signals from survival signals

2001 • 210 citations

CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response.

1996 • 198 citations

It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation

2002 • 183 citations

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.

1994 • 183 citations

The p70 S6 Kinase Integrates Nutrient and Growth Signals to Control Translational Capacity

2001 • 180 citations

Protein Kinase B Localization and Activation Differentially Affect S6 Kinase 1 Activity and Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 Phosphorylation

1999 • 175 citations

CD28: a signalling perspective

1996 • 156 citations

Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-co-stimulated human T cells

2000 • 153 citations

CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly

2002 • 140 citations

IL-2 binding activates a tyrosine-phosphorylated phosphatidylinositol-3-kinase.

1991 • 126 citations

Requirement for Akt (Protein Kinase B) in Insulin-induced Activation of Glycogen Synthase and Phosphorylation of 4E-BP1 (PHAS-1)

1999 • 102 citations

Interleukin 2- and Polyomavirus Middle T Antigen-Induced Modification of Phosphatidylinositol 3-Kinase Activity in Activated T Lymphocytes

1991 • 98 citations

Isolation of translationally controlled mRNAs by differential screening

2000 • 96 citations

Phosphoinositide 3-Kinase Regulation of T Cell Receptor-mediated Interleukin-2 Gene Expression in Normal T Cells

1998 • 70 citations

IκB Kinases Serve as a Target of CD28 Signaling

1998 • 69 citations

Intermediate Affinity Interleukin-2 Receptor Mediates Survival via a Phosphatidylinositol 3-Kinase-dependent Pathway

1997 • 67 citations

A Role for Perforin in Activation-Induced Cell Death

1998 • 58 citations

Translational control: a general mechanism for gene regulation during T cell activation

1998 • 54 citations

Isolation of translationally controlled mRNAs by differential screening

2000 • 44 citations

Phosphatidylinositide 3-Kinase Priming Couples c-FLIP to T Cell Activation

2003 • 40 citations

Effect of rapamycin on the cyclosporin A–resistant CD28-mediated costimulatory pathway

2002 • 39 citations

The analysis of costimulatory receptor signaling cascades in normal T lymphocytes using in vitro gene transfer and reporter gene analysis

2001 • 35 citations

Signal transduction pathways that contribute to increased protein synthesis during T-cell activation

2000 • 31 citations

Perforin‐dependent activation‐induced cell death acts through caspase 3 but not through caspases 8 or 9

2003 • 20 citations

The regulation of protein synthesis and translation factors by CD3 and CD28 in human primary T lymphocytes.

2002 • 20 citations

Effects of serum deprivation, insulin and dexamethasone on polysome percentages in C2C12 myoblasts and differentiating myoblasts

1999 • 14 citations