Bax is frequently compromised in Burkitt's lymphomas with irreversible resistance to Fas-induced apoptosis.

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

1994 • 1,120 citations

Fas ligand mediates activation-induced cell death in human T lymphocytes.

1995 • 949 citations

BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development

1996 • 745 citations

FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

1995 • 702 citations

Bax Deletion Further Orders the Cell Death Pathway in Cerebellar Granule Cells and Suggests a Caspase-independent Pathway to Cell Death

1997 • 390 citations

Hematopoietic Malignancies Demonstrate Loss-of-Function Mutations ofBAX

1998 • 291 citations

CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway.

1995 • 285 citations

Patterns of chromosomal breakpoint locations in Burkitt's lymphoma: relevance to geography and Epstein-Barr virus association

1991 • 257 citations

Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2.

1996 • 211 citations

Fas-mediated apoptosis in human prostatic carcinoma cell lines.

1997 • 189 citations

Spontaneous Development of Plasmacytoid Tumors in Mice with Defective Fas–Fas Ligand Interactions

1998 • 181 citations

BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability

1998 • 177 citations

The Non-Hodgkin's lymphomas

1990 • 136 citations

Caspase activity is required for commitment to Fas-mediated apoptosis

1997 • 132 citations

Molecular Biology of Cancer

1997 • 128 citations

Germinal Center Founder Cells Display Propensity for Apoptosis before Onset of Somatic Mutation

1997 • 126 citations

The Baxα:Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukaemia

1997 • 125 citations

Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype

1992 • 97 citations

Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation

1995 • 82 citations

Expression and function of CD95 (FAS/APO‐1) in leukaemia‐lymphoma tumour lines

1997 • 73 citations

Bax mutations in cell lines derived from hematological malignancies.

1995 • 56 citations

Soluble Fas Apo-1 splicing variants and apoptosis

1996 • 54 citations

Fas-Induced Apoptosis in Rat Thecal/Interstitial Cells Signals Through Sphingomyelin-Ceramide Pathway*

1998 • 52 citations

Differentiation and apoptosis of human germinal center B-lymphocytes

1997 • 48 citations

Expression of Apo‐1/Fas (CD95), Bcl‐2, Bax and Bcl‐x in myeloma cell lines: relationship between responsiveness to anti‐Fas mab and p53 functional status

1997 • 46 citations

The Bcl-xL and Bax-<FONT FACE = "SYMBOL">a</FONT> control points: modulation of apoptosis induced by cancer chemotherapy and relation to TPCK-sensitive protease and caspase activation

1997 • 44 citations

Activation and activation‐induced death of human tonsillar B cells and Burkitt lymphoma cells: lack of CD95 (Fas/APO‐1) ligand expression and function

1997 • 39 citations

Chronic persistent Epstein‐Barr virus infection of natural killer cells and B cells associated with granular lymphocytes expansion

1996 • 35 citations

Overexpression ofbax enhances the radiation sensitivity in human breast cancer cells

1997 • 33 citations

Expression of the epstein‐barr virus (EBV)‐encoded membrane protein LMP1 impairs the In vitro growth, clonability and tumorigenicity of an EBV‐negative burkitt lymphoma line

1992 • 31 citations

Differential expression of apoptosis, Bcl‐x and c‐Myc in normal and malignant lymphoid tissues

1997 • 27 citations

Expression of the Epstein-Barr Virus Protein LMP1 Mediates Tumor Regression In Vivo

1998 • 27 citations

Antiimmunoglobulin inhibition of Burkitt's lymphoma cell proliferation and concurrent reduction of c-myc and mu heavy chain gene expression.

1989 • 6 citations

Fas‐dependent and Fas‐independent Mechanisms for Selection of the Mature Human B Cell Repertoire

1997 • 5 citations