Activation of the CD95 (APO-1/Fas) pathway in drug- and γ-irradiation-induced apoptosis of brain tumor cells

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Apoptosis by Death Factor

1997 • 5,038 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors2

1973 • 2,213 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1996 • 1,001 citations

Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

1997 • 749 citations

Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression

1995 • 736 citations

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

1995 • 656 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells.

1997 • 456 citations

FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b

1997 • 405 citations

Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines.

1994 • 361 citations

Sensitization of Cancer Cells Treated With Cytotoxic Drugs to Fas-Mediated Cytotoxicity

1997 • 284 citations

Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways.

1995 • 282 citations

Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation.

1995 • 258 citations

The Role of APO‐1‐Mediated Apoptosis in the Immune System

1994 • 242 citations

Establishment of a Human Medulloblastoma Cell Line and Its Heterotransplantation into Nude Mice

1985 • 224 citations

Cross-Resistance of CD95- and Drug-Induced Apoptosis as a Consequence of Deficient Activation of Caspases (ICE/Ced-3 Proteases)

1997 • 198 citations

Comparison of Apoptosis in Wild-Type and Fas-Resistant Cells: Chemotherapy-Induced Apoptosis Is Not Dependent on Fas/Fas Ligand Interactions

1997 • 189 citations

The relationship between TP53 mutations and overexpression of p53 and prognosis in malignant gliomas of childhood.

1997 • 144 citations

Activation of a CrmA-insensitive, p35-sensitive Pathway in Ionizing Radiation-induced Apoptosis

1997 • 125 citations

Programmed cell death and radioresistance

1996 • 76 citations

Medulloblastoma: tumor biological and clinical perspectives

1991 • 76 citations

Cellular pharmacokinetics of doxorubicin in patients with chronic lymphocytic leukemia: comparison of bolus administration and continuous infusion

1993 • 61 citations

Brain Tumor Working Group Report on the 9th International Conference on Brain Tumor Research and Therapy

1993 • 54 citations

A pharmacokinetic study of high-dose continuous infusion cisplatin in children with solid tumors.

1989 • 48 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis???

1990 • 43 citations

Disturbances of the CD95 (APO-1/Fas) system in disorders of lymphohaematopoietic cells.

1996 • 37 citations

157 P53-dependent G1 arrest and P53-independent apoptosis influence the radiobiologic response of glioblastoma

1995 • 13 citations