TheDictyostelium cytoskeleton

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein

1990 • 1,035 citations

Disruption of the Dictyostelium Myosin Heavy Chain Gene by Homologous Recombination

1987 • 984 citations

Antisense RNA Inactivation of Myosin Heavy Chain Gene Expression in Dictyostelium discoideum

1987 • 677 citations

Chemotaxis in Eukaryotic Cells: A Focus on Leukocytes and Dictyostelium

1988 • 623 citations

How profilin promotes actin filament assembly in the presence of thymosin β4

1993 • 532 citations

Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose.

1994 • 484 citations

Life at the Leading Edge: The Formation of Cell Protrusions

1993 • 442 citations

Identification of an actin-binding protein from Dictyostelium as elongation factor 1a

1990 • 349 citations

Myosin I is located at the leading edges of locomoting Dictyostelium amoebae

1989 • 323 citations

Coronin, an actin binding protein of Dictyostelium discoideum localized to cell surface projections, has sequence similarities to G protein beta subunits.

1991 • 294 citations

INHIBITION OF PHAGOCYTOSIS AND PLASMA MEMBRANE MOBILITY OF THE CULTIVATED MACROPHAGE BY CYTOCHALASIN B

1974 • 289 citations

Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivo

1993 • 279 citations

Phylogenetic analysis of the myosin superfamily

1993 • 258 citations

Microtubule Severing by Elongation Factor 1α

1994 • 252 citations

Regulation of myosin self-assembly: phosphorylation of Dictyostelium heavy chain inhibits formation of thick filaments.

1980 • 252 citations

In pursuit of myosin function.

1989 • 252 citations

Dictyostelium mutants lacking the cytoskeletal protein coronin are defective in cytokinesis and cell motility.

1993 • 249 citations

Cytokinesis

1992 • 239 citations

Dictyostelium amoebae that lack G-actin-sequestering profilins show defects in F-actin content, cytokinesis, and development

1994 • 233 citations

The three faces of profilin

1993 • 179 citations

Severin, gelsolin, and villin share a homologous sequence in regions presumed to contain F-actin severing domains.

1988 • 170 citations

Relationship of pseudopod extension to chemotactic hormone‐induced actin polymerization in amoeboid cells

1988 • 161 citations

An actin-binding site containing a conserved motif of charged amino acid residues is essential for the morphogenic effect of villin

1992 • 160 citations

Redundancy in the microfilament system: Abnormal development of dictyostelium cells lacking two F-actin cross-linking proteins

1992 • 151 citations

The unconventional myosin encoded by the myoA gene plays a role in Dictyostelium motility.

1993 • 148 citations

G protein-linked signaling pathways control the developmental program of dictyostelium

1994 • 145 citations

Myosin IB null mutants of Dictyostelium exhibit abnormalities in motility

1991 • 143 citations

Orientation and three-dimensional organization of actin filaments in dividing cultured cells.

1993 • 141 citations

Generation and characterization of Dictyostelium cells deficient in a myosin I heavy chain isoform.

1990 • 137 citations

The Dictyostelium gelation factor shares a putative actin binding site with alpha-actinins and dystrophin and also has a rod domain containing six 100-residue motifs that appear to have a cross-beta conformation.

1989 • 132 citations

Kinetic analysis of F-actin depolymerization in polymorphonuclear leukocyte lysates indicates that chemoattractant stimulation increases actin filament number without altering the filament length distribution.

1991 • 129 citations

Cell behavior in Dictyostelium discoideum: preaggregation response to localized cyclic AMP pulses.

1982 • 129 citations

Dynein from Dictyostelium: primary structure comparisons between a cytoplasmic motor enzyme and flagellar dynein.

1992 • 129 citations

Changes in actin associated with the cytoskeleton following chemotactic stimulation of Dictyostelium discoideum

1983 • 127 citations

New actin-binding proteins from Dictyostelium discoideum

1984 • 127 citations

Targeted disruption of the ABP-120 gene leads to cells with altered motility.

1992 • 125 citations

Association of calmodulin and an unconventional myosin with the contractile vacuole complex of Dictyostelium discoideum.

1992 • 121 citations

Mechanism of interaction of Dictyostelium severin with actin filaments.

1982 • 121 citations

Inhibition of contractile vacuole function in vivo by antibodies against myosin-I

1993 • 120 citations

A 40,000-dalton protein from Dictyostelium discoideum affects assembly properties of actin in a Ca2+-dependent manner.

1982 • 120 citations

Small actin-binding proteins: the β-thymosin family

1993 • 119 citations

Myosin light chain kinase and myosin light chain phosphatase from Dictyostelium: effects of reversible phosphorylation on myosin structure and function.

1987 • 118 citations

Tyrosine Phosphorylation of Actin in Dictyostelium Associated with Cell-Shape Changes

1993 • 118 citations

Vegetative Dictyostelium cells containing 17 actin genes express a single major actin

1980 • 113 citations

Isolation of an abundant 50,000-dalton actin filament bundling protein from Dictyostelium amoebae.

1990 • 109 citations

The actin-binding protein comitin (p24) is a component of the Golgi apparatus.

1993 • 106 citations

Subcellular sorting of isoactins: Selective association of γ actin with skeletal muscle mitochondria

1983 • 104 citations

Regulation of CapZ, an actin capping protein of chicken muscle, by anionic phospholipids

1991 • 104 citations

A talin homologue of Dictyostelium rapidly assembles at the leading edge of cells in response to chemoattractant.

1995 • 99 citations

Effects of cAMP on single cell motility in Dictyostelium.

1984 • 97 citations

Length distribution of F-actin in Dictyostelium discoideum.

1990 • 96 citations

Hisactophilin, a histidine-rich actin-binding protein from Dictyostelium discoideum

1989 • 94 citations

F-actin binds to the cytoplasmic surface of ponticulin, a 17-kD integral glycoprotein from Dictyostelium discoideum plasma membranes.

1987 • 93 citations

Expression of a myosin regulatory light chain phosphorylation site mutant complements the cytokinesis and developmental defects of Dictyostelium RMLC null cells.

1994 • 93 citations

Structure of Actin Binding Proteins: Insights about Function at Atomic Resolution

1994 • 90 citations

Profilin, a weak CAP for actin and RAS

1991 • 89 citations

From the structure to the function of villin, an actin‐binding protein of the brush border

1990 • 86 citations

Targeted disruption of the Dictyostelium RMLC gene produces cells defective in cytokinesis and development.

1994 • 85 citations

Mechanisms of amoeboid chemotaxis: An evaluation of the cortical expansion model

1990 • 82 citations

Sequence, expression pattern, intracellular localization, and targeted disruption of the Dictyostelium myosin ID heavy chain isoform

1993 • 81 citations

Regulation of myosin self-assembly : phosphorylation of Dictyostelium heavy chain inhibits thick filament formation.

1980 • 80 citations

Structure of hisactophilin is similar to interleukin-1β and fibroblast growth factor

1992 • 79 citations

The Dictyostelium discoideum 30,000-dalton protein is an actin filament-bundling protein that is selectively present in filopodia.

1987 • 77 citations

Compartmentalization and actin binding properties of ABP‐50: The elongation factor‐1 alpha of Dictyostelium

1991 • 77 citations

Identification and immunolocalization of cytoplasmic dynein in dictyostelium

1990 • 75 citations

Organization of the actin multigene family of Dictyostelium discoideum and analysis of variability in the protein coding regions

1985 • 75 citations

Talin: Role at sites of cell‐substratum adhesion

1990 • 74 citations

Structure and evolution of the actin crosslinking proteins

1991 • 73 citations

Dictyostelium discoideum contains two profilin isoforms that differ in structure and fuction

1991 • 73 citations

Developmental consequences of the lack of myosin heavy chain in Dictyostelium discoideum

1988 • 71 citations

Coactosin, a 17 kDA F‐actin binding protein from Dictyostelium discoideum

1993 • 71 citations

Domain structure in actin-binding proteins: expression and functional characterization of truncated severin.

1991 • 70 citations

Genetic deletion of ABP-120 alters the three-dimensional organization of actin filaments in Dictyostelium pseudopods.

1995 • 69 citations

Identification of actin nucleation activity and polymerization inhibitor in ameboid cells: their regulation by chemotactic stimulation.

1989 • 69 citations

Dictyostelium annexin VII (synexin). cDNA sequence and isolation of a gene disruption mutant.

1991 • 68 citations

Strong increase in the tyrosine phosphorylation of actin upon inhibition of oxidative phosphorylation: Correlation with reversible rearrangements in the actin skeleton of Dictyostelium cells

1994 • 68 citations

Ca2+-independent F-actin Capping Proteins

1989 • 68 citations

The dictyostelium essential light chain is required for myosin function

1992 • 68 citations

The heat shock cognate protein from Dictyostelium affects actin polymerization through interaction with the actin-binding protein cap32/34.

1993 • 66 citations

Actomyosin organization during cytokinesis: Reversible translocation and differential redistribution in Dictyostelium

1989 • 66 citations

Stage-specific tyrosine phosphorylation of actin in Dictyostelium discoideum cells

1992 • 65 citations

The E. Donnall Thomas Lecture, 1993. The machinery of blood cell movements

1994 • 65 citations

Genetics of early Dictyostelium discoideum development

1988 • 64 citations

Changes in plasma-membrane-associated filaments during endocytosis and exocytosis in polymorphonuclear leukocytes

1981 • 63 citations

Are all pseudopods created equal?

1992 • 60 citations

Evidence that a 27-residue sequence is the actin-binding site of ABP-120

1991 • 59 citations

Sensory transduction in eukaryotes

1991 • 58 citations

Dynamics of the Dictyostelium cytoskeleton during chemotaxis.

1992 • 57 citations

Characterization of actin- and lipid-binding domains in severin, a calcium-dependent F-actin fragmenting protein

1992 • 57 citations

Structure of Severin Domain 2 in Solution

1995 • 56 citations

Ponticulin is the major high affinity link between the plasma membrane and the cortical actin network in Dictyostelium.

1994 • 56 citations

Actin crosslinking protein EF-1 a of Dictyostelium discoideum has a unique bonding rule that allows square-packed bundles

1992 • 56 citations

Severin is a gelsolin prototype

1990 • 55 citations

Differential localization of α‐actinin and the 30 kD actin‐bundling protein in the cleavage furrow, phagocytic cup, and contractile vacuole of Dictyostelium discoideum

1994 • 55 citations

Actin-related protein nomenclature and classification.

1994 • 55 citations

Gene-specific expression of the actin multigene family of Dictyostelium discoideum

1985 • 53 citations

F-Actin capping by cap3234 requires heterodimeric conformation and can be inhibited with PIP2

1991 • 51 citations

Ponticulin is an atypical membrane protein.

1994 • 51 citations

Chemotaxis of metastatic tumor cells: Clues to mechanisms from the Dictyostelium paradigm

1992 • 49 citations

Isolation of an actin-binding protein from membranes of Dictyostelium discoideum.

1985 • 48 citations

Inhibition of actin filament depolymerization by the Dictyostelium 30,000-D actin-bundling protein.

1992 • 47 citations

Studies on the transcription, translation, and structure of alpha-actinin in Dictyostelium discoideum.

1986 • 46 citations

A new protein that gels F actin in the cell cortex of Dictyostelium discoideum

1981 • 45 citations

Dictyostelium discoideum plasma membranes contain an actin-nucleating activity that requires ponticulin, an integral membrane glycoprotein.

1990 • 44 citations

Identification of a kinesin-like microtubule-based motor protein in Dictyostelium discoideum.

1989 • 43 citations

Identification of tubulin in Dictyostelium discoideum: characterization of some unique properties.

1983 • 42 citations

Isolation of a 240-kilodalton actin-binding protein from Dictyostelium discoideum.

1987 • 41 citations

Cap100, a novel phosphatidylinositol 4,5‐ bisphosphate‐ regulated protein that caps actin filaments but does not nucleate actin assembly

1992 • 41 citations

Discovery of myosin genes by physical mapping in Dictyostelium.

1994 • 41 citations

Dictyostelium discoideum mutants with conditional defects in phagocytosis.

1994 • 40 citations

The 100 kDa F‐actin capping protein of Dictyostelium amoebae is a villin prototype (‘protovillin’)

1993 • 39 citations

Indirect immunofluorescence localization of ponticulin in motile cells

1989 • 38 citations

The integral membrane protein, ponticulin, acts as a monomer in nucleating actin assembly.

1993 • 38 citations

Isolation and sequencing of cDNA clones encoding the Dictyostelium discoideum 30,000-dalton actin-bundling protein.

1991 • 37 citations

The pH-sensitive Actin-binding Protein Hisactophilin of Dictyostelium Exists in Two Isoforms Which Both Are Myristoylated and Distributed between Plasma Membrane and Cytoplasm

1995 • 35 citations

Patterns in Dictyostelium discoideum: the role of myosin II in the transition from the unicellular to the multicellular phase

1993 • 35 citations

Colocalization of F‐actin and 34‐kilodalton actin bundling protein in dictyostelium amoebae and cultured fibroblasts

1988 • 34 citations

In vivo acylation of Dictyostelium actin with palmitic acid

1985 • 33 citations

The highly divergent α- and β-tubulins from Dictyostelium discoideum are encoded by single genes

1993 • 33 citations

Purification and characterization of aginactin, a newly identified agonist-regulated actin-capping protein from Dictyostelium amoebae.

1991 • 30 citations

Actin‐Associated proteins in Dictyostelium discoideum

1990 • 30 citations

TheDictyostelium discoideum 30,000 dalton protein contributes to phagocytosis

1992 • 29 citations

Understanding the cortex of crawling cells: insights from Dictyostelium

1993 • 29 citations

A protein with homology to the C‐terminal repeat sequence of Octopus rhodopsin and synaptophysin is a member of a multigene family in Dictyostelium discoideum

1990 • 28 citations

The cAMP Receptor Family of Dictyostelium

1993 • 26 citations

An actin‐related protein from Dictyostelium discoideum is developmentallyregulated and associated with mitochondria

1995 • 20 citations

Heterodimeric capping proteins constitute a highly conserved group of actin‐binding proteins

1990 • 20 citations

A Ca²⁺ insensitive actin‐crosslinking protein from Dicytostelium discoideum

1985 • 19 citations

Acylation in vivo of the contact site A glycoprotein and of other membrane proteins in Dictyostelium discoideum

1984 • 19 citations

Differential association of three actin-bundling proteins with microfilaments in Dictyostelium amoebae.

1995 • 18 citations

Genetics of early Dictyostelium discoideum development.

1988 • 18 citations

Association of the Dictyostelium 30 kDa actin bundling protein with contact regions

1994 • 17 citations

Aginactin, an agonist-regulated F-actin capping activity is associated with an Hsc70 in Dictyostelium.

1993 • 17 citations

Localization, expression, evolutionary conservation, and structure of the 30,000 dalton actin bundling protein of Dictyostelium discoideum

1990 • 12 citations

Effect of microtubule inhibitors on the tubulin system ofDictyostelium discoideum

1982 • 8 citations

Effect of microtubule inhibitors on the tubulin system of Dictyostelium discoideum

1982 • 8 citations