Resident and Infiltrating Central Nervous System APCs Regulate the Emergence and Resolution of Experimental Autoimmune Encephalomyelitis

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Down-Regulation of the Macrophage Lineage Through Interaction with OX2 (CD200)

2000 • 983 citations

ICOS co-stimulatory receptor is essential for T-cell activation and function

2001 • 902 citations

T-cell co-stimulation through B7RP-1 and ICOS

1999 • 758 citations

Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

1991 • 675 citations

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

1996 • 642 citations

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

1995 • 622 citations

IL-10 Is Critical in the Regulation of Autoimmune Encephalomyelitis as Demonstrated by Studies of IL-10- and IL-4-Deficient and Transgenic Mice

1998 • 558 citations

TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination

1998 • 553 citations

Interferon‐γ confers resistance to experimental allergic encephalomyelitis

1996 • 478 citations

Failure to Suppress the Expansion of the Activated Cd4 T Cell Population in Interferon γ–Deficient Mice Leads to Exacerbation of Experimental Autoimmune Encephalomyelitis

2000 • 424 citations

TNF-alpha expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. Regulation by Th1 cytokines.

1995 • 401 citations

Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes

2000 • 393 citations

Lymphoid/Neuronal Cell Surface OX2 Glycoprotein Recognizes a Novel Receptor on Macrophages Implicated in the Control of Their Function

2000 • 386 citations

Immune Invasion of the Central Nervous System Parenchyma and Experimental Allergic Encephalomyelitis, But Not Leukocyte Extravasation from Blood, Are Prevented in Macrophage-Depleted Mice

1998 • 344 citations

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.

1994 • 300 citations

Microglia induce CD4 T lymphocyte final effector function and death.

1996 • 266 citations

IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide.

1999 • 246 citations

Experimental Autoimmune Encephalomyelitis Is Exacerbated in Mice Lacking theNOS2Gene

1998 • 226 citations

Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis

1999 • 219 citations

B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization.

1998 • 208 citations

IFN-γ Is Critical to the Control of Murine Autoimmune Encephalomyelitis and Regulates Both in the Periphery and in the Target Tissue: A Possible Role for Nitric Oxide

1999 • 204 citations

Immunohistochemical analysis of the rat central nervous system during experimental allergic encephalomyelitis, with special reference to Ia-positive cells with dendritic morphology.

1986 • 204 citations

A Critical Role for Lymphotoxin in Experimental Allergic Encephalomyelitis

1997 • 187 citations

Cutting Edge: B Cell-Deficient Mice Develop Experimental Allergic Encephalomyelitis with Demyelination After Myelin Oligodendrocyte Glycoprotein Sensitization

1998 • 177 citations

Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.

1994 • 168 citations

Kinetics and Cellular Origin of Cytokines in the Central Nervous System: Insight into Mechanisms of Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis

2000 • 164 citations

Class II transactivator and class II MHC gene expression in microglia: modulation by the cytokines TGF-β, IL-4, IL-13 and IL-10

1999 • 156 citations

Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis

1998 • 146 citations

Acceleration of Experimental Autoimmune Encephalomyelitis in Interleukin-10-Deficient Mice: Roles of Interleukin-10 in Disease Progression and Recovery

1998 • 145 citations

Our shifting understanding of the role of nitric oxide in autoimmune encephalomyelitis: a review

1999 • 141 citations

Astrocytes and microglia express inducible nitric oxide synthase in mice with experimental allergic encephalomyelitis

1997 • 137 citations

Macrophage-inactivating IL-13 suppresses experimental autoimmune encephalomyelitis in rats.

1994 • 135 citations

Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler’s virus–infected mice

1999 • 134 citations

Expression of Ia molecules by astrocytes during acute experimental allergic encephalomyelitis in the Lewis rat

1985 • 115 citations

Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats

1995 • 113 citations

In situ demonstration of proliferating cells in the rat central nervous system during experimental autoimmune encephalomyelitis. Evidence suggesting that most infiltrating T cells do not proliferate in the target organ.

1992 • 112 citations

Inhibition of macrophage Ia expression by nitric oxide.

1994 • 111 citations

Analysis of B7-1 and B7-2 costimulatory ligands in cultured mouse microglia: upregulation by interferon-γ and lipopolysaccharide and downregulation by interleukin-10, prostaglandin E2 and cyclic AMP-elevating agents

1997 • 110 citations

Nitric oxide via an inducible isoform of nitric oxide synthase is a possible factor to eliminate inflammatory cells from the central nervous system of mice with experimental allergic encephalomyelitis

1997 • 99 citations

Decreased severity of myelin oligodendrocyte glycoprotein peptide 33 – 35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR δ chain gene

1999 • 96 citations

Superoxide Prevents Nitric Oxide-Mediated Suppression of Helper T Lymphocytes: Decreased Autoimmune Encephalomyelitis in Nicotinamide Adenine Dinucleotide Phosphate Oxidase Knockout Mice

2000 • 93 citations

Dendritic cells and differential usage of the MHC class II transactivator promoters in the central nervous system in experimental autoimmune encephalitis

2000 • 78 citations

Cloning and expression of murine lymphotoxin cDNA.

1987 • 70 citations

Prevention and Treatment of Experimental Autoimmune Encephalomyelitis by CNI-1493, a Macrophage-Deactivating Agent

1998 • 67 citations

Macrophage-Derived Nitric Oxide Inhibits the Proliferation of Activated T Helper Cells and Is Induced during Antigenic Stimulation of Resting T Cells

2000 • 62 citations

Characterization of and Functional Antigen Presentation by Central Nervous System Mononuclear Cells from Mice Infected with Theiler’s Murine Encephalomyelitis Virus

1998 • 48 citations

In situ inactivation of infiltrating T cells in the central nervous system with autoimmune encephalomyelitis. The role of astrocytes.

1993 • 44 citations

Adoptive transfer of murine chronic-relapsing autoimmune encephalomyelitis

1987 • 44 citations

Reciprocal stimulation between TNF-α and nitric oxide may exacerbate CNS inflammation in experimental autoimmune encephalomyelitis

1998 • 33 citations

T cells are the main cell type expressing B7-1 and B7-2 in the central nervous system during acute, relapsing and chronic experimental autoimmune encephalomyelitis

1999 • 28 citations

An immunoelectron microscopical study of the expression of class II major histocompatibility complex during chronic relapsing experimental allergic encephalomyelitis in Biozzi AB/H mice

1991 • 25 citations

Global Inhibition of IL-2 and IFN-γ Secreting T cells Precedes Recovery from Acute Monophasic Experimental Autoimmune Encephalomyelitis

1996 • 15 citations

Separation and properties of lymphocytes obtained from the central nervous system.

1980 • 4 citations