IL-12p70-Dependent Th1 Induction by Human B Cells Requires Combined Activation with CD40 Ligand and CpG DNA

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

CpG Motifs in Bacterial DNA and Their Immune Effects

2002 • 2,520 citations

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

2002 • 2,438 citations

The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood

1999 • 2,255 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens

2001 • 1,989 citations

Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides

2002 • 1,919 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

1999 • 1,754 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

B cells regulate autoimmunity by provision of IL-10

2002 • 1,562 citations

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

2001 • 1,498 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells

1998 • 1,145 citations

Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells

2001 • 883 citations

Reciprocal regulation of polarized cytokine production by effector B and T cells

2000 • 817 citations

Prevention of Arthritis by Interleukin 10–producing B Cells

2003 • 816 citations

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

2001 • 798 citations

Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node

1998 • 762 citations

Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigens

1991 • 743 citations

CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells

1999 • 638 citations

Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells

2000 • 604 citations

Delineation of a CpG Phosphorothioate Oligodeoxynucleotide for Activating Primate Immune Responses In Vitro and In Vivo

2000 • 593 citations

Cutting Edge: Role of Toll-Like Receptor 9 in CpG DNA-Induced Activation of Human Cells

2001 • 571 citations

Flexibility of Mouse Classical and Plasmacytoid-derived Dendritic Cells in Directing T Helper Type 1 and 2 Cell Development

2003 • 561 citations

CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal

2000 • 558 citations

CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy.

1997 • 365 citations

Activation of influenza virus–specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity

2003 • 346 citations

Bacterial CpG-DNA Triggers Activation and Maturation of Human CD11c−, CD123+ Dendritic Cells

2001 • 306 citations

The Toll-like Receptor Protein Rp105 Regulates Lipopolysaccharide Signaling in B Cells

2000 • 302 citations

Rational design of new CpG oligonucleotides that combine B cell activation with high IFN‐α induction in plasmacytoid dendritic cells

2003 • 298 citations

The changing preference of T and B cells for partners as T‐dependent antibody responses develop

1997 • 292 citations

CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells

2003 • 291 citations

Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-γ production in cells from allergic individuals and inhibit IgE synthesisin vitro

1999 • 231 citations

Critical Role of IL-12 in Dendritic Cell-Induced Differentiation of Naive B Lymphocytes

1998 • 214 citations

CpG DNA and LPS induce distinct patterns of activation in human monocytes

1999 • 210 citations

Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity

2002 • 208 citations

B Lymphocytes as Antigen-Presenting Cells for CD4+ T Cell Priming In Vivo

1999 • 207 citations

Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes.

1995 • 201 citations

CpG Oligodeoxynucleotides as Vaccine Adjuvants in Primates

2002 • 199 citations

CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans

2000 • 191 citations

Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application

2002 • 189 citations

Do B cells drive the diversification of immune responses?

1993 • 189 citations

CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells.

2003 • 186 citations

Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide

2002 • 181 citations

Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys

1999 • 172 citations

DNA activates human immune cells through a CpG sequence‐dependent manner

1999 • 156 citations

Plasmacytoid dendritic cells: the key to CpG

2002 • 155 citations

In the absence of a CD40 signal, B cells are tolerogenic

1995 • 149 citations

Human Non-Germinal Center B Cell Interleukin (IL)-12 Production Is Primarily Regulated by T Cell Signals CD40 Ligand, Interferon γ, and IL-10: Role of B Cells in the Maintenance of T Cell Responses

1999 • 134 citations

Antigen-specific B cells preferentially induce CD4+ T cells to produce IL-4.

1997 • 117 citations

Sequential antigen‐specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c

1996 • 116 citations

CpG‐oligodeoxynucleotides enhance T‐cell receptor‐triggered interferon‐γ production and up‐regulation of CD69 via induction of antigen‐presenting cell‐derived interferon type I and interleukin‐12

2000 • 112 citations

Resting B Lymphocytes as APC for Naive T Lymphocytes: Dependence on CD40 Ligand/CD40

2000 • 89 citations

CpG-A Oligonucleotides Induce a Monocyte-Derived Dendritic Cell-Like Phenotype That Preferentially Activates CD8 T Cells

2003 • 81 citations

Partial activation of naive CD4 T cells and tolerance induction in response to peptide presented by resting B cells.

1997 • 69 citations

CD45 isoform phenotypes of human T cells: CD4+CD45RA–RO+ memory T cells re-acquire CD45RA without losing CD45RO

1999 • 64 citations

Distinct Response of Human B Cell Subpopulations in Recognition of an Innate Immune Signal, CpG DNA

2002 • 62 citations

Spontaneous and cationic lipid-mediated uptake of antisense oligonucleotides in human monocytes and lymphocytes.

1998 • 61 citations

B Cells Capturing Antigen Conjugated with CpG Oligodeoxynucleotides Induce Th1 Cells by Elaborating IL-12

2002 • 51 citations

Specific Suppression of Human Tumor Necrosis Factor-α Synthesis by Antisense Oligodeoxynucleotides

1996 • 37 citations

B Cells Present Antigen to CD4⁺ T Cells, but Fail to Produce IL‐12 Selective APC for Th2 Cell Development?

1997 • 18 citations