Rational design of new CpG oligonucleotides that combine B cell activation with high IFN‐α induction in plasmacytoid dendritic cells

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

CpG Motifs in Bacterial DNA and Their Immune Effects

2002 • 2,520 citations

The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood

1999 • 2,255 citations

Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides

2002 • 1,919 citations

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

1999 • 1,754 citations

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

2001 • 1,498 citations

Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells

2002 • 1,305 citations

Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells

2001 • 883 citations

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

2001 • 798 citations

CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells

1999 • 638 citations

Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells

2000 • 604 citations

Delineation of a CpG Phosphorothioate Oligodeoxynucleotide for Activating Primate Immune Responses In Vitro and In Vivo

2000 • 593 citations

Human Peripheral Blood Cells Differentially Recognize and Respond to Two Distinct CpG Motifs

2001 • 518 citations

Interferon in Oncological Practice: Review of Interferon Biology, Clinical Applications, and Toxicities

2001 • 511 citations

Bacterial CpG-DNA Triggers Activation and Maturation of Human CD11c−, CD123+ Dendritic Cells

2001 • 306 citations

A Pivotal Role for the Natural Interferon α–producing Cells (Plasmacytoid Dendritic Cells) in the Pathogenesis of Lupus

2001 • 284 citations

Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus.

1999 • 281 citations

Distinct CpG DNA and Polyinosinic-Polycytidylic Acid Double-Stranded RNA, Respectively, Stimulate CD11c− Type 2 Dendritic Cell Precursors and CD11c+ Dendritic Cells to Produce Type I IFN

2001 • 278 citations

IFN‐α/β enhances BCR‐dependent B cell responses

2002 • 250 citations

Anti-Double-Stranded DNA Antibodies and Immunostimulatory Plasmid DNA in Combination Mimic the Endogenous IFN-α Inducer in Systemic Lupus Erythematosus

1999 • 244 citations

Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA.

1998 • 212 citations

Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide

2002 • 211 citations

CpG DNA and LPS induce distinct patterns of activation in human monocytes

1999 • 210 citations

Cutting Edge: Rapid Induction of Mitogen-Activated Protein Kinases by Immune Stimulatory CpG DNA

1998 • 160 citations

Plasmacytoid dendritic cells: the key to CpG

2002 • 155 citations

Causing a commotion in the blood: immunotherapy progresses from bacteria to bacterial DNA

2000 • 131 citations

Mechanism of Action of CpG DNA

2000 • 119 citations

The natural interferon-α producing cells in systemic lupus erythematosus

2002 • 110 citations

Activation of Natural Interferon-α Producing Cells by Apoptotic U937 Cells Combined with Lupus IgG and its Regulation by Cytokines

2001 • 103 citations

Distinct CpG oligonucleotide sequences activate human γ δ T cells via interferon-α/-β

2001 • 86 citations

Importance of CpG Dinucleotides in Activation of Natural IFN‐α‐Producing Cells by a Lupus‐Related Oligodeoxynucleotide

2001 • 75 citations

Spontaneous and cationic lipid-mediated uptake of antisense oligonucleotides in human monocytes and lymphocytes.

1998 • 61 citations

Effects of type I/type II interferons and transforming growth factor‐β on B‐cell differentiation and proliferation. Definition of costimulation and cytokine requirements for immunoglobulin synthesis and expression

1998 • 42 citations

Examination of the inhibitory and stimulatory effects of IFN-α, -β, and -γ on human B-cell proliferation induced by various B-cell mitogens

1988 • 21 citations

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40L to induce high amounts of IL-12

2001 • 6 citations