CpG‐oligodeoxynucleotides enhance T‐cell receptor‐triggered interferon‐γ production and up‐regulation of CD69 via induction of antigen‐presenting cell‐derived interferon type I and interleukin‐12

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity

1997 • 1,008 citations

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants

1997 • 919 citations

Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells

1998 • 809 citations

CpG DNA Is a Potent Enhancer of Specific Immunity in Mice Immunized with Recombinant Hepatitis B Surface Antigen

1998 • 684 citations

CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

1998 • 667 citations

CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells

1999 • 638 citations

Macrophages ingest and are activated by bacterial DNA.

1996 • 579 citations

Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma.

1998 • 557 citations

Activation of Cutaneous Dendritic Cells by CpG-Containing Oligodeoxynucleotides: A Role for Dendritic Cells in the Augmentation of Th1 Responses by Immunostimulatory DNA

1998 • 543 citations

Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells.

1993 • 507 citations

CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis.

1998 • 457 citations

Cutting Edge: Modulation of Airway Inflammation by CpG Oligodeoxynucleotides in a Murine Model of Asthma

1998 • 416 citations

CpG‐containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants

1997 • 390 citations

Type I Interferon-mediated Stimulation of T Cells by CpG DNA

1998 • 361 citations

Cutting Edge: CpG Oligodeoxynucleotides Trigger Protective and Curative Th1 Responses in Lethal Murine Leishmaniasis

1998 • 349 citations

Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.

1996 • 311 citations

The Role of Stat4 in Species-Specific Regulation of Th Cell Development by Type I IFNs

1998 • 300 citations

Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells.

1998 • 272 citations

Immunostimulatory DNA: Sequence‐dependent production of potentially harmful or useful cytokines

1997 • 248 citations

Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-γ production in cells from allergic individuals and inhibit IgE synthesisin vitro

1999 • 231 citations

Influenza A Virus-Induced IFN-α/β and IL-18 Synergistically Enhance IFN-γ Gene Expression in Human T Cells

1998 • 218 citations

Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA.

1998 • 212 citations

Cutting Edge: Rapid Induction of Mitogen-Activated Protein Kinases by Immune Stimulatory CpG DNA

1998 • 160 citations

DNA as an Adjuvant: Capacity of Insect DNA and Synthetic Oligodeoxynucleotides to Augment T Cell Responses to Specific Antigen

1998 • 159 citations

DNA activates human immune cells through a CpG sequence‐dependent manner

1999 • 156 citations

CpG-oligodeoxynucleotides co-stimulate primary T cells in the absence of antigen-presenting cells

1999 • 155 citations

Bacterial DNA as immune cell activator

1998 • 122 citations

Synthetic Oligonucleotides with Certain Palindromes Stimulate Interferon Production of Human Peripheral Blood Lymphocytes in vitro

1994 • 89 citations

Semiquantitative determination of human cytokine mRna expression using TaqMan RT-PCR

1998 • 10 citations