B Cells Present Antigen to CD4⁺ T Cells, but Fail to Produce IL‐12 Selective APC for Th2 Cell Development?

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

1985 • 942 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

1990 • 679 citations

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

1996 • 676 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

1993 • 471 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

1995 • 428 citations

Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.

1996 • 349 citations

B lymphocytes can be competent antigen-presenting cells for priming CD4+ T cells to protein antigens in vivo.

1995 • 303 citations

Successful T cell priming in B cell-deficient mice.

1995 • 284 citations

The role of IL-12 in the induction of organ-specific autoimmune diseases

1995 • 277 citations

B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes.

1993 • 210 citations

Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice.

1996 • 198 citations

Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins.

1990 • 193 citations

Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells.

1995 • 150 citations

Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses.

1993 • 142 citations

Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells.

1995 • 127 citations

CD4+ T cell activation and tolerance induction in B cell knockout mice.

1996 • 103 citations

Dendritic cells but not B cells present antigenic complexes to class II-restricted T cells after administration of protein in adjuvant.

1996 • 99 citations

Targeting autoantigen to B cells prevents the induction of a cell-mediated autoimmune disease in rats.

1992 • 94 citations

Keratinocyte-derived T cell costimulation induces preferential production of IL-2 and IL-4 but not IFN-gamma.

1994 • 75 citations

Parameters of tolerance induction by antigen targeted to B lymphocytes.

1993 • 73 citations

B cells are not essential for peripheral T-cell tolerance.

1996 • 65 citations

The role of macrophage- and dendritic cell-derived IL12 in Th1 phenotype development

1995 • 51 citations

Selective immunosuppression by administration of major histocompatibility complex (MHC) class II-binding peptides. I. Evidence for in vivo MHC blockade preventing T cell activation.

1992 • 43 citations

The mode of protein antigen administration determines preferential presentation of peptide-class II complexes by lymph node dendritic or B cells

1997 • 25 citations

Analysis of low zone tolerance induction in normal and B cell-deficient mice.

1996 • 25 citations

Selective immunosuppression by administration of major histocompatibility complex class II-binding peptides. II. Preventive inhibition of primary and secondary in vivo antibody responses.

1993 • 16 citations