Posttranscriptional regulation of gene expression in liver regeneration: role of mRNA stability

AU-rich elements: characterization and importance in mRNA degradation

1995 • 1,936 citations

mRNA stability in mammalian cells

1995 • 1,258 citations

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

1994 • 777 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

Degradation of mRNA in eukaryotes

1995 • 648 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

The intracellular localization of messenger RNAs

1995 • 534 citations

Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1.

1993 • 533 citations

The Nonamer UUAUUUAUU Is the Key AU-Rich Sequence Motif That Mediates mRNA Degradation

1995 • 524 citations

Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.

1989 • 367 citations

Poly(A), poly(A) binding protein and the regulation of mRNA stability

1989 • 355 citations

Nuclear export of different classes of RNA is mediated by specific factors

1994 • 323 citations

Polyadenylic Acid Segment in mRNA Becomes Shorter with Age

1973 • 317 citations

Methyl groups in carcinogenesis: effects on DNA methylation and gene expression.

1992 • 301 citations

Control of c-myc mRNA half-life in vitro by a protein capable of binding to a coding region stability determinant.

1992 • 301 citations

Posttranscriptional silencing of reporter transgenes in tobacco correlates with DNA methylation.

1994 • 284 citations

Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region.

1994 • 267 citations

The Role of the Poly(A) Sequence in Mammalian Messenger RN

1981 • 254 citations

Physical isolation of nascent RNA chains transcribed by RNA polymerase II: evidence for cotranscriptional splicing.

1994 • 230 citations

Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation.

1995 • 220 citations

Induction patterns of 70 genes during nine days after hepatectomy define the temporal course of liver regeneration.

1993 • 205 citations

Translational Efficiency Is Regulated by the Length of the 3′ Untranslated Region

1996 • 193 citations

Poly(A) Tail Length Control Is Caused by Termination of Processive Synthesis

1995 • 191 citations

A redox switch and phosphorylation are involved in the post-translational up-regulation of the adenosine-uridine binding factor by phorbol ester and ionophore.

1991 • 184 citations

Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine.

1993 • 160 citations

AU RNA-binding factors differ in their binding specificities and affinities.

1992 • 157 citations

Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation.

1994 • 147 citations

Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

1994 • 140 citations

Faithful cell-cycle regulation of a recombinant mouse histone H4 gene is controlled by sequences in the 3'-terminal part of the gene.

1985 • 128 citations

Posttranscriptional clearance of hepatitis B virus RNA by cytotoxic T lymphocyte-activated hepatocytes.

1995 • 124 citations

Gene expression in regenerating and acute-phase rat liver

1990 • 122 citations

Differential regulation of multiple gap junction transcripts and proteins during rat liver regeneration.

1993 • 111 citations

Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing

1993 • 104 citations

Poly(A) binds to initiation factors and increases cap-dependent translation in vitro.

1994 • 101 citations

DIFFERENT HALF-LIVES OF INSULIN-LIKE GROWTH FACTOR I mRNAs THAT DIFFER IN LENGTH OF 3’ UNTRANSLATED SEQUENCE

1990 • 99 citations

Properties of a HeLa cell 3' exonuclease specific for degrading poly(A) tails of mammalian mRNA.

1992 • 98 citations

Differential Patterns of Expression of Three C/EBP Isoforms, HNF-1, and HNF-4 after Partial Hepatectomy in Rats

1993 • 91 citations

Human beta-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates lacking regions of exon I or exons I and II that have a cap-like structure at the 5′ termini.

1992 • 90 citations

Sequences Within the Last Intron function in RNA 3'-End Formation in Cultured Cells

1993 • 88 citations

Selective translational control and nonspecific posttranscriptional regulation of ribosomal protein gene expression during development and regeneration of rat liver.

1992 • 82 citations

An amino-terminal tetrapeptide specifies cotranslational degradation of beta-tubulin but not alpha-tubulin mRNAs.

1994 • 78 citations

Interleukin 1 induction of the c-jun promoter.

1993 • 73 citations

The Destabilizing Elements in the Coding Region of c-fos mRNA Are Recognized as RNA

1993 • 71 citations

Differential regulation and expression of jun, c-fos and c-myc proto-oncogenes during mouse liver regeneration and after inhibition of protein synthesis.

1990 • 71 citations

Post-transcriptional Regulation of 3-Hydroxy-3-methylglutaryl-CoA Reductase mRNA in Rat Liver

1989 • 68 citations

Changes in the stem-loop at the 3′ terminus of histone mRNA affects its nucleocytoplasmic transport and cytoplasmic regulation

1994 • 63 citations

Cyclin and cyclin-dependent kinase 1 mRNA expression in models of regenerating liver and human liver diseases

1993 • 62 citations

Newly synthesized RNA: simultaneous measurement in intact cells of transcription rates and RNA stability of insulin-like growth factor I, actin, and albumin in growth hormone-stimulated hepatocytes.

1991 • 58 citations

Purification of a human polyribosome-associated 3‘ to 5‘ exoribonuclease.

1994 • 57 citations

The half-life of immunoglobulin mRNA increases during B-cell differentiation: a possible role for targeting to membrane-bound polysomes.

1988 • 57 citations

Site-specific hypomethylation of the c-myc oncogene in human hepatocellular carcinoma.

1987 • 56 citations

Long-Range RNA Interaction of Two Sequence Elements Required for Endonucleolytic Cleavage of Human Insulin-Like Growth Factor II mRNAs

1995 • 55 citations

Alterations in mRNA stability during rat liver regeneration

1996 • 51 citations

Transcriptional and posttranscriptional regulation of apolipoprotein E, A-I, and A-II gene expression in normal rat liver and during several pathophysiologic states

1990 • 49 citations

Posttranscriptional regulation of cyclin B messenger RNA expression in the regenerating rat liver.

1994 • 44 citations

Microcomputer‐assisted kinetic modeling of mammalian gene expression

1993 • 42 citations

Overexpression of the class II P-glycoprotein gene in primary rat hepatocyte culture: evidence for increased mRNA stability.

1995 • 41 citations

Degradation of unstable interleukin-1 alpha mRNA in a rabbit reticulocyte cell-free system. Localization of an instability determinant to a cluster of AUUUA motifs.

1994 • 37 citations

Sequence determinants of c-myc mRNA turn-over: influence of 3' and 5' non-coding regions.

1988 • 37 citations

Inhibition by recombinant human interleukin-6 of the glucagon-dependent induction of phosphoenolpyruvate carboxykinase and of the insulin-dependent induction of glucokinase gene expression in cultured rat hepatocytes: Regulation of gene transcription and messenger RNA degradation

1994 • 34 citations

Several mRNAs with variable 3' untranslated regions and different stability encode the human PR264/SC35 splicing factor.

1994 • 34 citations

Regulation of fibronectin expression in rat regenerating liver

1995 • 33 citations

65‐kDa protein binds to destabilizing sequences in the IFN‐β mRNA coding and 3′ UTR

1993 • 33 citations

Regulation of insulin receptor gene expression. Cell cycle-mediated effects on insulin receptor mRNA stability.

1992 • 29 citations

Interferon-gamma- and phorbol myristate acetate-responsive elements involved in intercellular adhesion molecule-1 mRNA stabilization.

1994 • 28 citations

Role of messenger RNA subcellular localization in the posttranscriptional regulation of human histone gene expression

1990 • 25 citations

Posttranscriptional Down-Regulation of ras Oncogene Expression by Inhibitors of Cellular Glutathione

1993 • 25 citations

Alternatively polyadenylated vasoactive intestinal peptide mRNAs are differentially regulated at the level of stability.

1994 • 24 citations

The 5' and 3' non-coding sequences of the c-myc gene, required in vitro for its post-transcriptional regulation, are dispensable in vivo.

1993 • 20 citations

Both Coding Exons Of The c-myc Gene Contribute to Its Posttranscriptional Regulation in the Quiescent Liver and Regenerating Liver and after Protein Synthesis Inhibition

1995 • 19 citations

The mitogen-regulated protein/proliferin transcript is degraded in primary mouse embryo fibroblast but not 3T3 nuclei: altered RNA processing correlates with immortalization.

1994 • 19 citations

Transcriptional and posttranscriptional regulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase during liver regeneration.

1992 • 19 citations

Specific endonucleolytic cleavages of mouse albumin mRNA and their modulation during liver development

1995 • 15 citations

The adenovirus tripartite leader sequence can alter nuclear and cytoplasmic metabolism of a non-adenovirus mRNA within infected cells

1988 • 14 citations

Transcriptional rate and steady-state changes of retinoblastoma mRNA in regenerating rat liver

1994 • 13 citations

Influence of Transcriptional Regulation and mRNA Stability on Hemopexin Gene Expression in Regenerating Liver

1994 • 12 citations

Mutation Analysis of the Role for the Carboxy-Terminus Encoding Region in NGF-Induced Stabilization of GAP-43 mRNA

1994 • 10 citations

Changes in UsnRNA biosynthesis during rat liver regeneration

1994 • 9 citations

Expression of a growth arrest specific gene (gas‐6) during liver regeneration: Molecular mechanisms and signalling pathways

1994 • 8 citations

The Efficiency of Nuclear Processing of the Tyrosine Aminotransferase mRNA Transcript Increases after Partial Hepatectomy

1994 • 6 citations

Effect of triiodothyronine on rat liver polysome profiles and translational activity of mRNA after partial hepatectomy.

1992 • 3 citations