A requirement for Ras protein function in thrombin-stimulated mitogenesis in astrocytoma cells.

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1985 • 738 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family

1991 • 373 citations

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1992 • 361 citations

Control of transcription factors by signal transduction pathways: the beginning of the end

1992 • 360 citations

Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1.

1992 • 340 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)

1990 • 305 citations

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

1992 • 286 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity.

1992 • 284 citations

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

1987 • 254 citations

The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.

1992 • 248 citations

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

1992 • 235 citations

A Cytosolic Protein Catalyzes the Release of GDP from p21 ^ras

1990 • 231 citations

Platelet tyrosine-specific protein phosphorylation is regulated by thrombin.

1988 • 229 citations

Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C.

1987 • 203 citations

Practical design criteria for a dynamic ratio imaging system

1990 • 198 citations

Reciprocal Modulation of Astrocyte Stellation by Thrombin and Protease Nexin‐1

1990 • 198 citations

Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

1991 • 164 citations

Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae.

1989 • 162 citations

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor.

1992 • 146 citations

Identification of a nucleotide exchange-promoting activity for p21ras.

1990 • 144 citations

p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets.

1992 • 119 citations

The mitogenic effect of thrombin in vascular smooth muscle cells is largely due to basic fibroblast growth factor.

1993 • 111 citations

A G Protein Mutant That Inhibits Thrombin and Purinergic Receptor Activation of Phospholipase A₂

1990 • 108 citations

Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2.

1993 • 106 citations

Purification and Characterization of Human H-ras Proteins Expressed in Escherichia coli

1985 • 101 citations

Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae.

1992 • 91 citations

Interleukin 2-induced activation of Ras requires two domains of interleukin 2 receptor beta subunit, the essential region for growth stimulation and Lck-binding domain.

1992 • 83 citations

alpha-Thrombin-induced early mitogenic signalling events and G0 to S-phase transition of fibroblasts require continual external stimulation.

1985 • 83 citations

Protein Phosphatase 2A Potentiates Activity of Promoters Containing AP-1-Binding Elements

1993 • 77 citations

Biphasic Increase in c-jun mRNA Is Required for Induction of AP-1-Mediated Gene Transcription: Differential Effects of Muscarinic and Thrombin Receptor Activation

1992 • 71 citations

Inhibition of DNA synthesis in living cells by microinjection of Gi2 antibodies.

1992 • 60 citations

Interference with endogenous ras function inhibits cellular responses to wounding.

1993 • 48 citations

Expression of c-fos and AP-1 activity in senescent human fibroblasts is not sufficient for DNA synthesis.

1992 • 45 citations

Thrombin and trypsin act at the same site to stimulate phosphoinositide hydrolysis and calcium mobilization.

1989 • 41 citations

Thrombin Ca2+-dependently stimulates protein tyrosine phosphorylation in BC3H1 muscle cells

1993 • 28 citations