Characterization of the Binding of Different Conformational Forms of Plasminogen Activator Inhibitor-1 to Vitronectin

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

The plasminogen activator/plasmin system.

1991 • 1,196 citations

Physiological consequences of loss of plasminogen activator gene function in mice

1994 • 1,051 citations

Cell-Associated Plasminogen Activation: Regulation and Physiological Functions

1988 • 826 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants.

1985 • 555 citations

Structural basis of latency in plasminogen activator inhibitor-1

1992 • 552 citations

Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay

1988 • 538 citations

Novel purification of vitronectin from human plasma by heparin affinity chromatography.

1988 • 525 citations

Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin).

1988 • 484 citations

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

1996 • 460 citations

Detection and partial characterization of an inhibitor of plasminogen activator in human platelets.

1984 • 365 citations

Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis

1988 • 354 citations

Directed Plasminogen Activation at the Surface of Normal and Malignant Cells

1991 • 291 citations

Thrombosis and haemostasis

1988 • 263 citations

Serpin-Protease Complexes Are Trapped as Stable Acyl-Enzyme Intermediates

1995 • 240 citations

Molecular evolution of plasminogen activator inhibitor-1 functional stability.

1995 • 215 citations

Interaction of Plasminogen Activator Inhibitor (PAI-1) with Vitronectin

1989 • 191 citations

Extracellular matrix of cultured bovine aortic endothelial cells contains functionally active type 1 plasminogen activator inhibitor

1987 • 188 citations

The Inhibition Mechanism of Serpins

1995 • 176 citations

Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties.

1990 • 160 citations

Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells.

1987 • 158 citations

Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin.

1991 • 157 citations

Multimeric vitronectin. Identification and characterization of conformation-dependent self-association of the adhesive protein.

1993 • 155 citations

Serpin tertiary structure transformation

1991 • 155 citations

Mapping of binding sites for heparin, plasminogen activator inhibitor-1, and plasminogen to vitronectin's heparin-binding region reveals a novel vitronectin-dependent feedback mechanism for the control of plasmin formation.

1992 • 140 citations

Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms

1994 • 140 citations

Serpin reactive center loop mobility is required for inhibitor function but not for enzyme recognition.

1994 • 134 citations

Structure-function studies of the SERPIN plasminogen activator inhibitor type 1. Analysis of chimeric strained loop mutants

1990 • 127 citations

Localization of vitronectin binding domain in plasminogen activator inhibitor-1.

1994 • 126 citations

A Fluorescent Probe Study of Plasminogen Activator Inhibitor-1

1995 • 123 citations

Molecular Basis of Thrombosis and Hemostasis

1996 • 119 citations

Structural requirements for the extracellular interaction of plasminogen activator inhibitor 1 with endothelial cell matrix-associated vitronectin.

1990 • 116 citations

Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms

1994 • 112 citations

Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1

1995 • 106 citations

Structural and Functional Analysis of the Plasminogen Activator Inhibitor-1 Binding Motif in the Somatomedin B Domain of Vitronectin

1996 • 103 citations

Engineering Plasminogen Activator Inhibitor 1 Mutants with Increased Functional Stability

1994 • 95 citations

Binding of Type 1 Plasminogen Activator Inhibitor to the Extracellular Matrix of Cultured Bovine Endothelial Cells

1989 • 94 citations

Observation of a noncovalent ribonuclease S-protein/S-peptide complex by electrospray ionization mass spectrometry

1993 • 93 citations

Vitronectin exists in two structurally and functionally distinct forms in human plasma

1989 • 91 citations

Kinetics of inactivation of alpha-thrombin by plasminogen activator inhibitor-1. Comparison of the effects of native and urea-treated forms of vitronectin

1993 • 91 citations

Saturation mutagenesis of the plasminogen activator inhibitor-1 reactive center.

1992 • 88 citations

Role of the Catalytic Serine in the Interactions of Serine Proteinases with Protein Inhibitors of the Serpin Family

1995 • 85 citations

The Acid Stabilization of Plasminogen Activator Inhibitor-1 Depends on Protonation of a Single Group That Affects Loop Insertion into β-Sheet A

1995 • 77 citations

Plasminogen Activator Inhibitor-1 and Vitronectin Promote the Cellular Clearance of Thrombin by Low Density Lipoprotein Receptor-related Proteins 1 and 2

1996 • 72 citations

Alteration of vitronectin. Characterization of changes induced by treatment with urea.

1993 • 70 citations

The PAI-1/Vitronectin Interaction: Two Cats in a Bag?

1995 • 70 citations

Time-resolved polarized fluorescence spectroscopy studies of plasminogen activator inhibitor type 1: conformational changes of the reactive center upon interactions with target proteases, vitronectin and heparin

1995 • 69 citations

Purification of human plasminogen activator inhibitor (PAI-1) from Escherichia coli and separation of its active and latent forms by hydrophobic interaction chromatography

1995 • 51 citations

Determination of the vitronectin binding site on plasminogen activator inhibitor 1 (PAI‐1)

1994 • 51 citations

Kinetic analysis of the interaction between type 1 plasminogen activator inhibitor and vitronectin and evidence that the bovine inhibitor binds to a thrombin-derived amino-terminal fragment of bovine vitronectin

1991 • 43 citations

Conformational lability of vitronectin: induction of an antigenic change by alpha-thrombin-serpin complexes and by proteolytically modified thrombin

1989 • 41 citations

Quantitative evaluation of solution equilibrium binding interactions by affinity partitioning: Application to specific and nonspecific protein-heparin interactions

1991 • 39 citations

Localization of a Vitronectin Binding Region of Plasminogen Activator Inhibitor-1

1995 • 36 citations

Identification of a PAI-1 binding site in vitronectin

1994 • 35 citations

Characterization of the Denaturation and Renaturation of Human Plasma Vitronectin

1996 • 34 citations

Complex formation between plasminogen activator inhibitor 1 and vitronectin in purified systems and in plasma

1990 • 30 citations

Identification of the plasminogen activator inhibitor-1 binding heptapeptide in vitronectin

1993 • 28 citations

[33] Microprocessor-based radioimmunoassay data analysis

1981 • 16 citations

Hormone Regulation of Tissue-Type Plasminogen Activator Gene Expression and Plasminogen Activator-Mediated Proteolysis

1991 • 16 citations