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AMoRe: an automated package for molecular replacement

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Protein Inhibitors of Proteinases

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1989 • 898 citations

Human α1-proteinase inhibitor

1984 • 773 citations

Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants.

1985 • 555 citations

Structural basis of latency in plasminogen activator inhibitor-1

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Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin).

1988 • 484 citations

Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor.

1986 • 386 citations

[22] Detecting and overcoming crystal twinning

1997 • 374 citations

Biological implications of a 3 å structure of dimeric antithrombin

1994 • 360 citations

cDNA cloning of human plasminogen activator-inhibitor from endothelial cells.

1986 • 350 citations

Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family.

1986 • 343 citations

The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions

1994 • 279 citations

Inhibitory conformation of the reactive loop of α1-antitrypsin

1996 • 243 citations

Molecular evolution of plasminogen activator inhibitor-1 functional stability.

1995 • 215 citations

Plasminogen activator inhibitor type‐1 : reactive center and amino‐terminal heterogeneity determined by protein and cDNA sequencing

1986 • 207 citations

Plasminogen Activator Inhibitor 1 (PAI-1) in Plasma: Its Role in Thrombotic Disease

1995 • 198 citations

Plasminogen activator inhibitor 1 (PAI) is bound to vitronectin in plasma

1988 • 178 citations

The Inhibition Mechanism of Serpins

1995 • 176 citations

Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop

1994 • 175 citations

Crystal structure of plakalbumin, a proteolytically nicked form of ovalbumin

1990 • 164 citations

Preparation and Characterization of Latent α1-Antitrypsin

1995 • 155 citations

Serpin tertiary structure transformation

1991 • 155 citations

Regulation of cell adhesion by PAI‐1

1999 • 154 citations

The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion

1999 • 154 citations

Identification of a conformationally distinct form of plasminogen activator inhibitor-1, acting as a noninhibitory substrate for tissue-type plasminogen activator.

1992 • 142 citations

Serpin reactive center loop mobility is required for inhibitor function but not for enzyme recognition.

1994 • 134 citations

Localization of vitronectin binding domain in plasminogen activator inhibitor-1.

1994 • 126 citations

Characterization of the Binding of Different Conformational Forms of Plasminogen Activator Inhibitor-1 to Vitronectin

1997 • 123 citations

A 2.6 å structure of a serpin polymer and implications for conformational disease 1 1Edited by R. Huber

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Purification of active human plasminogen activator inhibitor 1 from Escherichia coli

1989 • 113 citations

The mechanism of the reaction between human plasminogen-activator inhibitor 1 and tissue plasminogen activator

1990 • 112 citations

Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1

1995 • 106 citations

Review

1996 • 96 citations

Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

1998 • 93 citations

Interconversions between active, inert and substrate forms of denatured/refolded type-1 plasminogen activator inhibitor

1993 • 92 citations

A substrate‐like form of plasminogen‐activator‐inhibitor type 1

1992 • 90 citations

Structure-function relationships in serpins: current concepts and controversies.

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Purification and characterization of natural and recombinant human plasminogen activator inhibitor‐1 (PAI‐1)

1988 • 83 citations

Divining the serpin inhibition mechanism: a suicide substrate ‘springe’?

1995 • 82 citations

Substrate Behavior of Plasminogen Activator Inhibitor-1 Is Not Associated with a Lack of Insertion of the Reactive Site Loop

1996 • 68 citations

Identification of the Binding Site for a Low-Molecular-Weight Inhibitor of Plasminogen Activator Inhibitor Type 1 by Site-Directed Mutagenesis

1998 • 63 citations

Conformational Studies on Plasminogen Activator Inhibitor (PAI-1) in Active, Latent, Substrate, and Cleaved Forms

1995 • 55 citations

Crystal structure of an uncleaved α₁‐antitrypsin reveals the conformation of its inhibitory reactive loop

1995 • 51 citations

Predictive value of fibrinolytic factors in coronary heart disease

1999 • 36 citations

Dynamic structural and functional relationships in recombinant plasminogen activator inhibitor-1 (rPAI-1)

1993 • 28 citations

cDNA for bovine type 1 plasminogen activator Inhibitor (PMI-1)

1989 • 17 citations

Evaluation of the mechanism of inactivation of plasminogen activator inhibitor-1 by monoclonal antibodies using a stable variant

1998 • 15 citations

The latent tendencies of PAI-1

1992 • 12 citations

A Spectroscopic Study of the Structures of Latent, Active and Reactive‐Center‐Cleaved Type‐1 Plasminogen‐Activator Inhibitor

1996 • 8 citations

Predictive value of fibrinolytic factors in coronary heart disease

1999 • 7 citations

Plasminogen activator inhibitor 1 (PAI-1) in its active conformation: crystallization and preliminary X-ray diffraction data

1999 • 4 citations

Induction of conformational changes within crystals of plasminogen activator inhibitor-1 (PAI-1)

1999 • 2 citations