Characterization of the interaction of plasminogen activator inhibitor type 1 with vitronectin by surface plasmon resonance

Quantitative determination of surface concentration of protein with surface plasmon resonance using radiolabeled proteins

1991 • 1,037 citations

The serpin superfamily of proteinase inhibitors: structure, function, and regulation.

1994 • 879 citations

Experimental design for kinetic analysis of protein-protein interactions with surface plasmon resonance biosensors

1997 • 556 citations

Determination of Rate and Equilibrium Binding Constants for Macromolecular Interactions Using Surface Plasmon Resonance: Use of Nonlinear Least Squares Analysis Methods

1993 • 540 citations

Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin).

1988 • 484 citations

Structure and Biological Role of Vitronectin

1991 • 477 citations

Antigen-Antibody Binding and Mass Transport by Convection and Diffusion to a Surface: A Two-Dimensional Computer Model of Binding and Dissociation Kinetics

1993 • 363 citations

Surface Plasmon Resonance Detection and Multispot Sensing for Direct Monitoring of Interactions Involving Low-Molecular-Weight Analytes and for Determination of Low Affinities

1995 • 278 citations

Characterization of human S protein, an inhibitor of the membrane attack complex of complement. Demonstration of a free reactive thiol group

1985 • 212 citations

Interaction of Plasminogen Activator Inhibitor (PAI-1) with Vitronectin

1989 • 191 citations

Theoretical Analysis of Protein Concentration Determination Using Biosensor Technology under Conditions of Partial Mass Transport Limitation

1997 • 178 citations

Effects of polystyrene surface chemistry on the biological activity of solid phase fibronectin and vitronectin, analysed with monoclonal antibodies

1993 • 174 citations

Reliable determination of binding affinity and kinetics using surface plasmon resonance biosensors

1997 • 167 citations

Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin.

1991 • 157 citations

Multimeric vitronectin. Identification and characterization of conformation-dependent self-association of the adhesive protein.

1993 • 155 citations

Regulation of cell adhesion by PAI‐1

1999 • 154 citations

Structure of plasminogen activator inhibitor 1 (PAI-1) and its function in fibrinolysis: an update

1995 • 153 citations

Stability of Plasminogen Activator Inhibitor 1 (PAI-1)

1989 • 148 citations

Identification of a conformationally distinct form of plasminogen activator inhibitor-1, acting as a noninhibitory substrate for tissue-type plasminogen activator.

1992 • 142 citations

The somatomedin B domain of vitronectin. Structural requirements for the binding and stabilization of active type 1 plasminogen activator inhibitor.

1994 • 126 citations

Localization of vitronectin binding domain in plasminogen activator inhibitor-1.

1994 • 126 citations

Characterization of the Binding of Different Conformational Forms of Plasminogen Activator Inhibitor-1 to Vitronectin

1997 • 123 citations

Structural requirements for the extracellular interaction of plasminogen activator inhibitor 1 with endothelial cell matrix-associated vitronectin.

1990 • 116 citations

Identification of and partial characterization of platelet vitronectin: evidence for complex formation with platelet-derived plasminogen activator inhibitor-1

1989 • 114 citations

Kinetics of the inhibition of plasminogen activators by the plasminogen-activator inhibitor. Evidence for ‘second-site’ interactions

1988 • 113 citations

The interaction of plasminogen activator inhibitor 1 with plasminogen activators (tissue-type and urokinase-type) and fibrin: localization of interaction sites and physiologic relevance

1991 • 99 citations

Binding of Type 1 Plasminogen Activator Inhibitor to the Extracellular Matrix of Cultured Bovine Endothelial Cells

1989 • 94 citations

Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

1998 • 93 citations

Time-resolved polarized fluorescence spectroscopy studies of plasminogen activator inhibitor type 1: conformational changes of the reactive center upon interactions with target proteases, vitronectin and heparin

1995 • 69 citations

The structural puzzle of how serpin serine proteinase inhibitors work

1996 • 66 citations

Identification of the Binding Site for a Low-Molecular-Weight Inhibitor of Plasminogen Activator Inhibitor Type 1 by Site-Directed Mutagenesis

1998 • 63 citations

Demonstration of an Upper Limit to the Range of Association Rate Constants Amenable to Study by Biosensor Technology Based on Surface Plasmon Resonance

1996 • 58 citations

Conformational Studies on Plasminogen Activator Inhibitor (PAI-1) in Active, Latent, Substrate, and Cleaved Forms

1995 • 55 citations

Determination of the vitronectin binding site on plasminogen activator inhibitor 1 (PAI‐1)

1994 • 51 citations

Identification of functional interaction sites on proteins using bacteriophage-displayed random epitope libraries

1995 • 44 citations

The Use of Fluorescent Probes to Characterize Conformational Changes in the Interaction between Vitronectin and Plasminogen Activator Inhibitor-1

1997 • 41 citations

Anti-thrombotic Effect of a PAI-1 Inhibitor in Rats Given Endotoxin

1996 • 35 citations

Characterization of the Denaturation and Renaturation of Human Plasma Vitronectin

1996 • 34 citations

Plasminogen activator inhibitor type-1 interacts exclusively with the proteinase domain of tissue plasminogen activator

1994 • 31 citations

Complex formation between plasminogen activator inhibitor 1 and vitronectin in purified systems and in plasma

1990 • 30 citations

Evidence that conformational changes upon the transition of the native to the modified form of vitronectin are not limited to the heparin binding domain

1995 • 28 citations

Epitopes on plasminogen activator inhibitor type-1 important for binding to tissue plasminogen activator

1997 • 26 citations

The Composition of Complexes between Plasminogen Activator Inhibitor 1, Vitronectin and either Thrombin or Tissue-type Plasminogen Activator

1997 • 22 citations

Separation of Active and Inactive Forms of Recombinant Human Plasminogen Activator Inhibitor Type 1 (PAI-1) Expressed in Chinese Hamster Ovary Cells: Comparison with Native Human PAI-1

1994 • 21 citations

Crystallization and X‐ray diffraction data of the cleaved form of plasminogen activator inhibitor‐1

1995 • 19 citations

Characterisation of the complex of plasminogen activator inhibitor type 1 with tissue-type plasminogen activator by mass spectrometry and size-exclusion chromatography

1996 • 19 citations

Murine monoclonal antibodies against active site epitopes on human endothelial plasminogen activator inhibitor (PAI-1)

1990 • 14 citations

An antibody ragment against PAI-1 inhibits PAI-1 activity and stimulates fibrinolysis in vitro and in vivo

1994 • 11 citations

Studies on the interaction between plasminogen activator inhibitor-1 and vitronectin

1992 • 10 citations

Protein movement during complex-formation between tissue plasminogen activator and plasminogen activator inhibitor-1

1999 • 9 citations

Definition of epitopes within plasminogen activator inhibitor type-1 (PAI-1) using multiple peptide synthesis

1993 • 9 citations

Comparison of chromogenic substrates for tissue plasminogen activator and the effects on the stability of plasminogen activator inhibitor type-1

1997 • 4 citations