G protein specificity in receptor-effector coupling. Analysis of the roles of G0 and Gi2 in GH4C1 pituitary cells.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Current protocols in molecular biology

1988 • 7,584 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits

1991 • 1,076 citations

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

1992 • 1,009 citations

Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits

1992 • 623 citations

Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents

1991 • 576 citations

Cloning of the cDNA and gene for a human D2 dopamine receptor.

1989 • 488 citations

Adenylyl cyclases

1992 • 397 citations

Expression cloning and signaling properties of the rat glucagon receptor

1993 • 393 citations

Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins

1993 • 393 citations

Different β-subunits determine G-protein interaction with transmembrane receptors

1992 • 390 citations

Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells.

1992 • 371 citations

Signal sorting and amplification through G protein-coupled receptors

1989 • 338 citations

Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.

1990 • 302 citations

Characterization of functional receptors for somatostatin in rat pituitary cells in culture.

1978 • 290 citations

Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family.

1992 • 285 citations

Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.

1990 • 270 citations

Differential coupling of dopaminergic D2 receptors expressed in different cell types. Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in LtK- fibroblasts, hyperpolarization, and cytosolic-free Ca2+ concentration decrease in GH4C1 cells.

1990 • 235 citations

Tubulin binds specifically to the signal-transducing proteins, Gs alpha and Gi alpha 1.

1990 • 204 citations

Two distinct Gi-proteins mediate formyl peptide receptor signal transduction in human leukemia (HL-60) cells

1989 • 183 citations

Thrombin and Phorbol Esters Cause the Selective Phosphorylation of a G Protein Other Than Gi in Human Platelets

1989 • 181 citations

Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system.

1990 • 173 citations

Antibodies to the GTP binding protein, Go, antagonize noradrenaline-induced calcium current inhibition in NG108-15 hybrid cells

1989 • 159 citations

Coupling of a cloned rat dopamine-D2 receptor to inhibition of adenylyl cyclase and prolactin secretion.

1990 • 149 citations

Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.

1990 • 147 citations

Identification of the subunits of GTP-binding proteins coupled to somatostatin receptors.

1991 • 144 citations

Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process.

1991 • 131 citations

A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs.

1990 • 130 citations

Cell-specific signaling of the 5-HT1A receptor. Modulation by protein kinases C and A.

1991 • 89 citations

Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing.

1991 • 84 citations

Differential Sensitivity of the Short and Long Human Dopamine D₂ Receptor Subtypes to Protein Kinase C

1992 • 79 citations

Dihydrofolate reductase from amethopterin-resistant Lactobacillus casei. Sequences of the cyanogen bromide peptides and complete sequences of the enzyme.

1978 • 41 citations

Agonist binding to rat brain somatostatin receptors alters the interaction of the receptors with guanine nucleotide-binding regulatory proteins.

1992 • 30 citations

Indications for selective coupling to phosphoinositide hydrolysis or to adenylate cyclase inhibition by endogenous muscarinic receptor subtypes M3 and M4 but not by M2 in tumor cell lines

1990 • 24 citations