Differential Sensitivity of the Short and Long Human Dopamine D₂ Receptor Subtypes to Protein Kinase C

Inositol phosphates and cell signalling

1989 • 4,058 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Cloning and expression of a rat D2 dopamine receptor cDNA

1988 • 1,125 citations

Protein kinase recognition sequence motifs

1990 • 1,014 citations

Alternative splicing directs the expression of two D2 dopamine receptor isoforms

1989 • 692 citations

Multiple D2 dopamine receptors produced by alternative RNA splicing

1989 • 642 citations

Cloning of the cDNA and gene for a human D2 dopamine receptor.

1989 • 488 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.

1988 • 400 citations

Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.

1985 • 312 citations

Role of phosphorylation in desensitization of the β-adrenoceptor

1990 • 300 citations

Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor

1989 • 271 citations

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.

1987 • 259 citations

Pharmacological characterization of the D2 dopamine receptor negatively coupled with adenylate cyclase in rat anterior pituitary.

1983 • 254 citations

Molecular characterization of a gene of the ‘EGF family’ expressed in undifferentiated human NTERA2 teratocarcinoma cells.

1989 • 251 citations

Molecular biology of the dopamine receptors

1991 • 247 citations

Differential coupling of dopaminergic D2 receptors expressed in different cell types. Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in LtK- fibroblasts, hyperpolarization, and cytosolic-free Ca2+ concentration decrease in GH4C1 cells.

1990 • 235 citations

Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system.

1990 • 173 citations

Coupling of a cloned rat dopamine-D2 receptor to inhibition of adenylyl cyclase and prolactin secretion.

1990 • 149 citations

Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process.

1991 • 131 citations

A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs.

1990 • 130 citations

Transfected D2 dopamine receptors mediate the potentiation of arachidonic acid release in Chinese hamster ovary cells.

1991 • 124 citations

Transcription mediated by a cAMP-responsive promoter element is reduced upon activation of dopamine D2 receptors.

1991 • 114 citations

Cell-specific signaling of the 5-HT1A receptor. Modulation by protein kinases C and A.

1991 • 89 citations

Dopamine, acting through D-2 receptors, inhibits rat striatal adenylate cyclase by a GTP-dependent process.

1986 • 78 citations

Single Cell Monitoring of Cytosolic Calcium Reveals Subtypes of Rat Lactotrophs with Distinct Responses to Dopamine and Thyrotropin-Releasing Hormone*

1987 • 67 citations

Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization.

1991 • 65 citations

Ionomycin acts as an ionophore to release TRH-regulated Ca2+ stores from GH4C1 cells

1986 • 64 citations

Dopamine Inhibits Prolactin Secretion Stimulated by the Calcium Channel Agonist Bay-K-8644 through a Pertussis Toxin-Sensitive G Protein in Anterior Pituitary Cells*

1988 • 51 citations

Association of two pertussis toxin-sensitive G-proteins with the D2-dopamine receptor from bovine striatum.

1989 • 31 citations

Phosphorylation by Cyclic AMP‐Dependent Protein Kinase Modulates Agonist Binding to the D₂ Dopamine Receptor

1991 • 27 citations

Signal transduction by the epidermal growth factor receptor after functional desensitization of the receptor tyrosine protein kinase activity.

1990 • 26 citations

Conditional transformation mediated via a pertussis toxin-sensitive receptor signalling pathway.

1992 • 25 citations

Conditional transformation mediated via a pertussis toxin-sensitive receptor signalling pathway

1992 • 15 citations