High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling

Global and societal implications of the diabetes epidemic

2001 • 5,825 citations

The Adaptive Brain: Aging and Neurocognitive Scaffolding

2008 • 2,415 citations

Protein carbonyl groups as biomarkers of oxidative stress

2003 • 2,210 citations

The Metabolic Syndrome

2008 • 1,889 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Adipocytokines and the Metabolic Complications of Obesity

2008 • 730 citations

Diet‐induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle‐aged rats

2008 • 680 citations

Age-related changes in total and regional fat distribution

2009 • 659 citations

The Nrf2–ARE Pathway

2008 • 550 citations

Removal of Visceral Fat Prevents Insulin Resistance and Glucose Intolerance of Aging

2002 • 540 citations

Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.

1996 • 493 citations

Role of oxidative stress and protein oxidation in the aging process1,2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease.” The full list of papers may be found on the homepage of the journal.

2002 • 473 citations

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

2008 • 441 citations

The Adipocyte as an Endocrine Cell

2008 • 424 citations

Obesity and Hypertriglyceridemia Produce Cognitive Impairment

2008 • 369 citations

Neurobiology of Feeding and Energy Expenditure

2007 • 344 citations

Oxidative Stress Signaling in Alzheimers Disease

2008 • 334 citations

Is oxidative damage the fundamental pathogenic mechanism of Alzheimer’s and other neurodegenerative diseases?

2002 • 295 citations

ENERGY INTAKE, MEAL FREQUENCY, AND HEALTH: A Neurobiological Perspective

2005 • 251 citations

NF-E2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet

2008 • 241 citations

Protein oxidation and cellular homeostasis: Emphasis on metabolism

2006 • 237 citations

Adiposity signals and food reward: expanding the CNS roles of insulin and leptin

2003 • 218 citations

Visceral adipose tissue modulates mammalian longevity

2008 • 199 citations

Maternal obesity is necessary for programming effect of high-fat diet on offspring

2009 • 198 citations

Leptin signaling in brain: A link between nutrition and cognition?

2008 • 197 citations

Obesity and vulnerability of the CNS

2008 • 187 citations

Human cerebral neuropathology of Type 2 diabetes mellitus

2008 • 170 citations

Alzheimer Disease and the Role of Free Radicals in the Pathogenesis of the Disease

2008 • 152 citations

Consumption of a high-fat diet alters the homeostatic regulation of energy balance

2004 • 147 citations

Oxidative Damage and Cognitive Dysfunction: Antioxidant Treatments to Promote Healthy Brain Aging

2008 • 126 citations

Age-related insulin resistance: is it an obligatory finding? The lesson from healthy centenarians

2001 • 111 citations

CNS Regulation of Glucose Homeostasis

2009 • 101 citations

Effects of short‐term Western diet on cerebral oxidative stress and diabetes related factors in APP × PS1 knock‐in mice

2008 • 84 citations

Treating Neurodegeneration by Modifying Mitochondria: Potential Solutions to a “Complex” Problem

2007 • 78 citations

Life Span Extension in Mice by Food Restriction Depends on an Energy Imbalance

2009 • 60 citations

LMP2 Knock-Out Mice Have Reduced Proteasome Activities and Increased Levels of Oxidatively Damaged Proteins

2006 • 55 citations

A metabolic basis for Alzheimer disease.

2003 • 55 citations

Comparison of metabolic rate and oxidative stress between two different strains of mice with varying response to caloric restriction

2008 • 54 citations

Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels

2008 • 48 citations

Diet-induced metabolic disturbances as modulators of brain homeostasis

2008 • 39 citations

Metabolic aspects of the extreme longevity

2007 • 37 citations

Development of a water-escape motivated version of the Stone T-maze for mice

2009 • 21 citations