Protein oxidation and cellular homeostasis: Emphasis on metabolism

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Mitochondrial free radical generation, oxidative stress, and aging11This article is dedicated to the memory of our dear friend, colleague, and mentor Lars Ernster (1920–1998), in gratitude for all he gave to us.

2000 • 2,864 citations

Antioxidant enzymes and human diseases

1999 • 2,028 citations

Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression

2002 • 2,020 citations

Free radical-mediated oxidation of free amino acids and amino acid residues in proteins

2003 • 1,787 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

Free Radicals in Biology: Oxidative Stress and the Effects of Ionizing Radiation

1994 • 1,396 citations

Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production

2003 • 1,281 citations

Tissue-specific functions of individual glutathione peroxidases

1999 • 1,115 citations

Protein Oxidation

2000 • 935 citations

Reactive Oxygen-Mediated Protein Oxidation in Aging and Disease

1998 • 891 citations

UV-light-induced signal cascades and skin aging

2002 • 881 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

Degradation of oxidized proteins by the 20S proteasome

2001 • 846 citations

Degradation of oxidized proteins in mammalian cells

1997 • 845 citations

Oxidative Alterations in Alzheimer's Disease

1999 • 772 citations

Oxidative Stress, Antioxidant Defenses, and Damage Removal, Repair, and Replacement Systems

2000 • 762 citations

Protein Oxidation in Aging and Age‐Related Diseases

2001 • 656 citations

Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals

2001 • 642 citations

Carbonyl modified proteins in cellular regulation, aging, and disease2,3 2Guest Editor: Earl Stadtman 3This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease.” The full list of papers may be found on the homepage of the journal.

2002 • 637 citations

Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and ‘aggresomes’ during oxidative stress, aging, and disease

2004 • 630 citations

Oxidative damage during aging targets mitochondrial aconitase

1997 • 612 citations

Reactive Oxygen-Mediated Protein Oxidation in Aging and Disease

1997 • 605 citations

Activation of Chaperone-mediated Autophagy during Oxidative Stress

2004 • 575 citations

Oxidative Stress, Antioxidant Defenses, and Damage Removal, Repair, and Replacement Systems

2000 • 564 citations

Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI.

1993 • 550 citations

The Proteasome, a Novel Protease Regulated by Multiple Mechanisms

1999 • 540 citations

Extracellular superoxide dismutase and other superoxide dismutase isoenzymes in tissues from nine mammalian species

1984 • 512 citations

Oxidative Stress and Autophagy

2006 • 506 citations

Copper,zinc superoxide dismutase is primarily a cytosolic protein in human cells.

1992 • 492 citations

Antioxidant Function of Thioredoxin and Glutaredoxin Systems

2000 • 491 citations

Role of oxidative stress and protein oxidation in the aging process1,2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease.” The full list of papers may be found on the homepage of the journal.

2002 • 473 citations

Protein Disulfide Bond Formation in the Cytoplasm during Oxidative Stress

2004 • 445 citations

High-quality life extension by the enzyme peptide methionine sulfoxide reductase

2002 • 440 citations

Ubiquitin Conjugation Is Not Required for the Degradation of Oxidized Proteins by Proteasome

2002 • 440 citations

Mitochondrial adenine nucleotide translocase is modified oxidatively during aging

1998 • 408 citations

Inhibition of Krebs Cycle Enzymes by Hydrogen Peroxide: A Key Role of α-Ketoglutarate Dehydrogenase in Limiting NADH Production under Oxidative Stress

2000 • 406 citations

Lipofuscin

2003 • 403 citations

Modulation of Mitochondrial Function by Hydrogen Peroxide

2001 • 374 citations

Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar.

1983 • 373 citations

3-Nitropropionate, the toxic substance of Indigofera , is a suicide inactivator of succinate dehydrogenase

1977 • 371 citations

Lipofuscin: Mechanisms of formation and increase with age

1998 • 364 citations

Proteins damaged by oxygen radicals are rapidly degraded in extracts of red blood cells.

1987 • 336 citations

Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids

1993 • 323 citations

The Radicals in Cigarette Tar: Their Nature and Suggested Physiological Implications

1983 • 313 citations

Detection of elevated reactive oxygen species level in cultured rat hepatocytes treated with aflatoxin B1

1996 • 310 citations

Neurotoxicant-induced animal models of Parkinson?s disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration

2004 • 303 citations

Inactivation of succinate dehydrogenase by 3-nitropropionate.

1979 • 303 citations

Catalytic Activities of the 20 S Proteasome, a Multicatalytic Proteinase Complex

2000 • 301 citations

Overexpression of peptide-methionine sulfoxide reductase inSaccharomyces cerevisiaeand human T cells provides them with high resistance to oxidative stress

1998 • 268 citations

Neurodegeneration and neuroprotection in Parkinson disease

2004 • 256 citations

Extracellular superoxide dismutase

2005 • 252 citations

Role of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in normal cell function and in cell pathology

1997 • 241 citations

Oxygen Effect in the Radiolysis of Proteins

1984 • 220 citations

Potential role of nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase in apoptosis and oxidative stress

2001 • 215 citations

Nitrated and oxidized plasma proteins in smokers and lung cancer patients.

2001 • 212 citations

The role of oxidative stress in the ochratoxin A-mediated toxicity in proximal tubular cells

2002 • 206 citations

Lysosomes, a meeting point of proteins, chaperones, and proteases

1997 • 201 citations

Proteomic identification of glyceraldehyde 3-phosphate dehydrogenase as an inhibitory target of hydrogen peroxide in Arabidopsis

2005 • 201 citations

Mitochondrial Creatine Kinase Is a Prime Target of Peroxynitrite-induced Modification and Inactivation

1998 • 196 citations

Fas/Fas Ligand Interaction Contributes to UV-Induced Apoptosis in Human Keratinocytes

1997 • 183 citations

Macroxyproteinase (M.O.P.): A 670 kDa Proteinase complex that degrades oxidatively denatured proteins in red blood cells

1989 • 182 citations

Detection of Hydrogen Peroxide and Hydroxyl Radicals in Murine Skin Fibroblasts under UVB Irradiation

1995 • 181 citations

Selectivity of protein oxidative damage during aging in Drosophila melanogaster

2001 • 177 citations

Untitled

1998 • 168 citations

Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress

2004 • 166 citations

UVB Light Induces Nuclear Factor κB (NFκB) Activity Independently from Chromosomal DNA Damage in Cell-Free Cytosolic Extracts

1994 • 165 citations

Oxidative stress and recovery from oxidative stress are associated with altered ubiquitin conjugating and proteolytic activities in bovine lens epithelial cells

1995 • 156 citations

Cellular aspects of photocarcinogenesis

2005 • 147 citations

Inhibition of creatine kinase by S‐nitrosoglutathione

1996 • 145 citations

Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents

1992 • 138 citations

In vivo ozone exposure induces antioxidant/stress-related responses in murine lung and skin

2004 • 132 citations

Harmful health effects of cigarette smoking.

2003 • 131 citations

Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain

1996 • 129 citations

Proteolysis, free radicals, and aging1,2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease.” The full list of papers may be found on the homepage of the journal.

2002 • 127 citations

Hydroperoxide-induced oxidative stress impairs heart muscle cell carbohydrate metabolism

1994 • 126 citations

Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents

1992 • 122 citations

Redox Regulation of Heat Shock Protein Expression by Signaling Involving Nitric Oxide and Carbon Monoxide: Relevance to Brain Aging, Neurodegenerative Disorders, and Longevity

2006 • 120 citations

Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages.

1994 • 115 citations

Extracellular glutathione peroxidase in human lung epithelial lining fluid and in lung cells

1996 • 113 citations

Inhibition of the creatine kinase reaction decreases the contractile reserve of isolated rat hearts

1995 • 108 citations

Oxygen Effect in the Radiolysis of Proteins

1980 • 106 citations

Oxidation of glyceraldehyde-3-phosphate dehydrogenase enhances its binding to nucleic acids

2003 • 101 citations

The Creatine Kinase System in Human Skin: Protective Effects of Creatine Against Oxidative and UV Damage In Vitro and In Vivo

2005 • 90 citations

Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation

2004 • 89 citations

Increase of creatine kinase activity in the visual cortex of human brain during visual stimulation: A ³¹p NMR magnetization transfer study

1997 • 88 citations

Selective Inhibition of the Tricarboxylic Acid Cycle of GABAergic Neurons with 3‐Nitropropionic Acid In Vivo

1995 • 87 citations

Ultraviolet-B-Induced Oxidative DNA Base Damage in Primary Normal Human Epidermal Keratinocytes and Inhibition by a Hydroxyl Radical Scavenger

2003 • 87 citations

Effects of acute creatine kinase inhibition on metabolism and tension development in isolated single myocytes

2004 • 87 citations

Cyanidin-3-O-β-glucopyranoside, a natural free-radical scavenger against aflatoxin B1- and ochratoxin A-induced cell damage in a human hepatoma cell line (Hep G2) and a human colonic adenocarcinoma cell line (CaCo-2)

2005 • 85 citations

Reversible S-nitrosation of Creatine Kinase by Nitric Oxide in Adult Rat Ventricular Myocytes

1998 • 81 citations

The mechanism of chondrocyte hydrogen peroxide damage. Depletion of intracellular ATP due to suppression of glycolysis caused by oxidation of glyceraldehyde-3-phosphate dehydrogenase.

1989 • 78 citations

The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS‐1), are downregulated during replicative senescence of human WI‐38 fibroblasts

2004 • 76 citations

Specificity of Age-Related Carbonylation of Plasma Proteins in the Mouse and Rat

2002 • 75 citations

Overexpression of Phospholipid-hydroperoxide Glutathione Peroxidase in Human Dermal Fibroblasts Abrogates UVA Irradiation-induced Expression of Interstitial Collagenase/Matrix Metalloproteinase-1 by Suppression of Phosphatidylcholine Hydroperoxide-mediated NFκB Activation and Interleukin-6 Release

2004 • 74 citations

Induction and inactivation of catalase and superoxide dismutase of Escherichia coli by ozone

1987 • 73 citations

Reaction of Aflatoxin B₁ Oxidation Products with Lysine

2002 • 71 citations

S-thiolation of creatine kinase and glycogen phosphorylase b initiated by partially reduced oxygen species

1988 • 66 citations

3‐Nitropropionic acid induces a spectrum of Huntington’s disease‐like neuropathology in rat striatum

1999 • 66 citations

Structural and Functional Changes in Catalase Induced by Near-UV Radiation

1996 • 62 citations

Effects of ozone on DNA single-strand breaks and 8-oxoguanine formation in A549 cells

2003 • 60 citations

Effects of free radicals on cytosolic creatine kinase activities and protection by antioxidant enzymes and sulfhydryl compounds.

2000 • 59 citations

Responses to Peroxynitrite in Yeast: Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) as a Sensitive Intracellular Target for Nitration and Enhancement of Chaperone Expression and Ubiquitination

2000 • 59 citations

Inhibition of cathepsins and related proteases by amino acid, peptide, and protein hydroperoxides

2006 • 59 citations

Pyruvate Restores Contractile Function and Antioxidant Defenses of Hydrogen Peroxide-Challenged Myocardium

2002 • 57 citations

Free radical-induced inactivation of creatine kinase: influence on the octameric and dimeric states of the mitochondrial enzyme (Mib-CK)

1999 • 56 citations

Decrease in heart mitochondrial creatine kinase activity due to oxygen free radicals

1992 • 53 citations

The metabolic consequences of hydroperoxide perfusion on the isolated rat heart

1989 • 53 citations

Inactivation of NADP+-dependent isocitrate dehydrogenase by reactive oxygen species

2001 • 51 citations

Catalase: Its role in xenobiotic detoxification

1989 • 47 citations

Dose-Dependent Biochemical Changes in Rat Central Nervous System after 12-Week Exposure to 1-Bromopropane

2003 • 47 citations

Hydrogen peroxide induces association between glyceraldehyde 3‐phosphate dehydrogenase and phospholipase D2 to facilitate phospholipase D2 activation in PC12 cells

2003 • 42 citations

The Effect of H2O2 and Tertiary Butyl Hydroperoxide Upon a Murine Immortal Lens Epithelial Cell Line, αTN4-1

2002 • 41 citations

Dietary Butylated Hydroxytoluene Protects against Aflatoxicosis in Turkeys

2002 • 41 citations

3-Nitropropionic acid: an astrocyte-sparing neurotoxin in vitro

1999 • 39 citations

In vitro inhibition of catalase activity by cigarette smoke: relevance for oxidative stress

1998 • 38 citations

Evaluation of the neurotoxicity of glycidamide, an epoxide metabolite of acrylamide: behavioral, neurochemical and morphological studies

1995 • 38 citations

Inactivation of Rabbit Muscle Creatine Kinase by Hydrogen Peroxide

1992 • 36 citations

Glutaric Acid Administration Impairs Energy Metabolism in Midbrain and Skeletal Muscle of Young Rats

2005 • 34 citations

Presence of Peroxyradicals in Cigarette Smoke and the Scavenging Effect of Shikonin, a Naphthoquinone Pigment

2005 • 33 citations

Ascorbate-induced oxidation of glyceraldehyde-3-phosphate dehydrogenase

2003 • 31 citations

Oxidative Damage in Parkinson's Disease

2005 • 27 citations

Evidence for ATP and ubiquitin dependent degradation of proteins in cultured bovine lens epithelial cells

1991 • 27 citations

Lens crystallins and oxidation: the special case of γS

2001 • 26 citations

Free radical-induced inactivation of creatine kinase: influence on the octameric and dimeric states of the mitochondrial enzyme (Mib-CK)

1999 • 22 citations

Free radicals and protein degradation in human red blood cells.

1985 • 22 citations

Creatine kinase activities in brain and blood:possible neurotoxic indicator of acrylamide intoxication.

1996 • 20 citations

Ozone-induced inactivation of antioxidant enzymes

2003 • 19 citations

Brain creatine kinase reaction rates and reactant concentrations during seizures in developing rats

1997 • 19 citations

Increase of Enzyme Activities following the in vitro Peroxidation of Normal Human Red Blood Cells

1988 • 17 citations

Inactivation of Creatine Phosphokinase by Superoxide during Reperfusion Injury

1988 • 17 citations

Haematological and biochemical studies in broiler chicks fed ochratoxin and inoculated with inclusion body hepatitis virus, singly and in concurrence.

1998 • 15 citations

The effect of ochratoxin A on the concentration of protein carbonyls in rats.

2005 • 13 citations

Inhibition of glyceraldehyde-3-phosphate dehydrogenase in tissues of the rat by acrylamide and related compounds.

1985 • 13 citations

Comparative free radical chemistry in the radiolytic deamination and dephosphorylation of bio-organic molecules. II. Oxygenated solutions

1989 • 5 citations

Action of acrylamide on selected enzymes of energy metabolism in denervated cat peripheral nerves

1985 • 5 citations