Age-related insulin resistance: is it an obligatory finding? The lesson from healthy centenarians

Role of Insulin Resistance in Human Disease

1988 • 12,099 citations

Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease

1991 • 4,548 citations

Oxidative Stress and Diabetic Vascular Complications

1996 • 1,947 citations

Hyperinsulinemia as an Independent Risk Factor for Ischemic Heart Disease

1996 • 1,727 citations

Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

1997 • 1,611 citations

Insulin Resistance and Insulin Secretory Dysfunction as Precursors of Non-Insulin-Dependent Diabetes Mellitus: Prospective Studies of Pima Indians

1993 • 1,516 citations

Carbohydrates, dietary fiber, and incident type 2 diabetes in older women

2000 • 1,284 citations

Protein glycation and oxidative stress in diabetes mellitus and ageing

1991 • 882 citations

Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.

1994 • 852 citations

Hypertriglyceridaemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes

1989 • 622 citations

Mechanisms of Insulin Resistance in Aging

1983 • 543 citations

The immunology of exceptional individuals: the lesson of centenarians

1995 • 538 citations

Age Changes in Body Composition Revealed by Computed Tomography

1983 • 468 citations

Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age [published erratum appears in J Clin Endocrinol Metab 1995 Sep;80(9):2799]

1994 • 454 citations

Characterization of the insulin resistance of aging.

1983 • 395 citations

Isolated Postchallenge Hyperglycemia and the Risk of Fatal Cardiovascular Disease in Older Women and Men: The Rancho Bernardo Study

1998 • 378 citations

Physiological importance of dehydroepiandrosterone

1994 • 367 citations

Growth Hormone, Body Composition, and Aging

1985 • 365 citations

A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM

1995 • 350 citations

Pathogenesis of Age-Related Glucose Intolerance in Man: Insulin Resistance and Decreased β-Cell Function*

1985 • 350 citations

Insulin Action and Age: European Group for the Study of Insulin Resistance (EGIR)

1996 • 327 citations

Exercise training guidelines for the elderly

1999 • 326 citations

Therapeutic Effects of Dehydroepiandrosterone (DHEA) in Diabetic Mice

1982 • 291 citations

Insulin Resistance in Aging Is Related to Abdominal Obesity

1993 • 285 citations

Oxidative stress and insulin action: is there a relationship?

1996 • 285 citations

Recombinant Human Insulin-Like Growth Factor I Increases Insulin Sensitivity and Improves Glycemic Control in Type II Diabetes

1996 • 283 citations

Magnesium and glucose homeostasis

1990 • 269 citations

Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.

1998 • 262 citations

Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver.

1988 • 252 citations

A pathogenic role of visceral fat beta 3-adrenoceptors in obesity.

1995 • 247 citations

Decreased testosterone and dehydroepiandrosterone sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men

1994 • 226 citations

Contribution of visceral fat mass to the insulin resistance of aging

1995 • 223 citations

Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1

1995 • 216 citations

Complex alteration of thyroid function in healthy centenarians.

1993 • 208 citations

Daily magnesium supplements improve glucose handling in elderly subjects

1992 • 203 citations

Dietary carbohydrates and insulin sensitivity: a review of the evidence and clinical implications

1997 • 185 citations

AN ADRENAL-SECRETED "ANDROGEN": DEHYDROISOANDROSTERONE SULFATE. ITS METABOLISM AND A TENTATIVE GENERALIZATION ON THE METABOLISM OF OTHER STEROID CONJUGATES IN MAN.

1965 • 184 citations

Serum Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 in Healthy Centenarians: Relationship with Plasma Leptin and Lipid Concentrations, Insulin Action, and Cognitive Function

1997 • 175 citations

Insulin-like growth factor I stimulates lipid oxidation, reduces protein oxidation, and enhances insulin sensitivity in humans.

1993 • 170 citations

Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age.

1992 • 167 citations

Effect of aging on response to exercise training in humans: skeletal muscle GLUT-4 and insulin sensitivity

1999 • 157 citations

Insulin Resistance andβ-Cell Dysfunction in Aging: The Importance of Dietary Carbohydrate*

1988 • 155 citations

Effect of Weight Loss with Reduction of Intra-Abdominal Fat on Lipid Metabolism in Older Men*

2000 • 154 citations

Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus.

1992 • 146 citations

Effect of Trypsin Treatment of Rat Adipocytes on Biological Effects and Binding of Insulin and Insulin‐Like Growth Factors

1981 • 143 citations

Variation in adrenergic regulation of lipolysis between omental and subcutaneous adipocytes from obese and non-obese men

1997 • 133 citations

Oxidative Stress and Advancing Age: Results in Healthy Centenarians

1998 • 129 citations

Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic rats

1997 • 124 citations

Comparison of the metabolic effects of recombinant human insulin-like growth factor-I and insulin. Dose-response relationships in healthy young and middle-aged adults.

1994 • 123 citations

Long-Term Dietary Restriction in Older-Aged Rhesus Monkeys: Effects on Insulin Resistance

1995 • 123 citations

Insulin-like growth factor-1 and insulin resistance in skeletal muscles of adult and old rats

1994 • 111 citations

Circulating Levels of Insulin-Like Growth Factor (IGF) Binding Protein-1 and -3 in Aging Men: Relationships to Insulin, Glucose, IGF, and Dehydroepiandrosterone Sulfate Levels and Anthropometric Measures¹

1997 • 106 citations

Weight loss reduces abdominal fat and improves insulin action in middle-aged and older men with impaired glucose tolerance

1995 • 101 citations

Dehydroepiandrosterone, dehydroepiandrosterone sulfate, obesity, waist-hip ratio, and noninsulin-dependent diabetes in postmenopausal women: the Rancho Bernardo Study.

1996 • 100 citations

Endogenous sex hormones: Impact on lipids, lipoproteins, and insulin

1995 • 99 citations

The Pathogenesis of Type II Diabetes Mellitus:A Polygenic Disease

1996 • 94 citations

Pharmacological doses of vitamin E and insulin action in elderly subjects

1994 • 94 citations

Opposing Actions of Dehydroepiandrosterone and Testosterone on Insulin Sensitivity: In Vivo and In Vitro Studies of Hyperandrogenic Females

1991 • 90 citations

Effects of age, smoking and vitamins on plasma DHEAS levels: a cross-sectional study in men.

1992 • 88 citations

Systemic Oxidative Stress and Its Relationship with Age and Illness

1996 • 85 citations

Effects of insulin-like growth factor I on the rates of glucose transport and utilization in rat skeletal muscle in vitro

1992 • 83 citations

Body composition, body fat distribution, and resting metabolic rate in healthy centenarians

1995 • 78 citations

Evaluation of Abdominal Fat Distribution in Noninsulin-Dependent Diabetes Mellitus: Relationship to Insulin Resistance1

1998 • 75 citations

Hyperinsulinemia predicts multiple atherogenic changes in lipoproteins in elderly subjects.

1994 • 75 citations

Lipolysis in Intraabdorninal Adipose Tissues of Obese Women and Men

1993 • 74 citations

Effects of a reduction in circulating insulin by metformin on serum dehydroepiandrosterone sulfate in nondiabetic men.

1994 • 70 citations

DHEA Treatment Reduces Fat Accumulation and Protects Against Insulin Resistance in Male Rats

1998 • 68 citations

Relationship of body fat percentage and fat distribution with dehydroepiandrosterone sulfate in premenopausal females.

1993 • 68 citations

Candidate Genes for Insulin Resistance

1996 • 65 citations

Hyperinsulinemia, risk factors, and coronary heart disease. The Zutphen Elderly Study.

1994 • 62 citations

Aging and high concentrations of glucose potentiate injury to mitochondrial DNA

1999 • 60 citations

Does the mitochondrial DNA play a role in the pathogenesis of diabetes?

1992 • 60 citations

Effects of Insulin and IGF-I on Vascular Smooth Muscle Glucose and Cation Metabolism

1996 • 56 citations

Aging is associated with decreased suppression of insulin-like growth factor binding protein-1 by insulin.

1993 • 53 citations

Role of impaired intracellular glucose metabolism in the insulin resistance of aging

1992 • 49 citations

Chronic intake of pharmacological doses of vitamin E might be useful in the therapy of elderly patients with coronary heart disease

1995 • 43 citations

Changes in anthropometric indices of body composition with age in a healthy elderly population

1989 • 39 citations

Flow-induced dilatation in isolated resistance arteries from control and streptozotocin-diabetic rats

1998 • 36 citations

Low Plasma Insulin‐Like Growth Factor‐1 Concentrations Predict Worsening of Insulin‐Mediated Glucose Uptake in Older People

1999 • 30 citations

Insulin resistance and advancing age: What role for dehydroepiandrosterone sulfate?

1997 • 28 citations

Treatment of NIDDM IDDM, and other insulin-resistant states with IGF-I: Physiological and clinicaI considerations

1995 • 28 citations

Preserved Antilipolytic Insulin Action Is Associated with a Less Atherogenic Plasma Lipid Profile in Healthy Centenarians

1997 • 20 citations

Is Visceral Adiposity a Significant Correlate of Subcutaneous Adipose Cell Lipolysis in Men?¹

1999 • 19 citations

Comparison of daily diets containing 400 kcal (1.67 MJ) of either protein or glucose, and their effects on the response to subsequent total fasting in obese subjects

1989 • 14 citations

Changes in glucose turnover parameters during muscular exercise: role of age

1990 • 5 citations