Disruption of nNOS‐PSD95 protein–protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

Glutamate receptor ion channels

2005 • 3,667 citations

Nitric oxide synthases: structure, function and inhibition

2001 • 3,508 citations

Nitric oxide synthases: structure, function and inhibition

2001 • 2,499 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Chronic catheterization of the spinal subarachnoid space

1976 • 2,244 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Intrathecal morphine in mice: A new technique

1980 • 1,880 citations

Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

1996 • 1,589 citations

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

1992 • 1,180 citations

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

1998 • 1,147 citations

Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions

2002 • 964 citations

Specific Coupling of NMDA Receptor Activation to Nitric Oxide Neurotoxicity by PSD-95 Protein

1999 • 821 citations

PSD-95 Assembles a Ternary Complex with theN-Methyl-d-aspartic Acid Receptor and a Bivalent Neuronal NO Synthase PDZ Domain

1999 • 525 citations

Memories of NMDA receptors and LTP

1995 • 484 citations

Isolation and culture of adult rat hippocampal neurons

1997 • 447 citations

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

1991 • 386 citations

Expression Mechanisms Underlying NMDA Receptor‐Dependent Long‐Term Potentiation

1999 • 374 citations

Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.

1987 • 373 citations

Cell Signaling and the Genesis of Neuropathic Pain

2004 • 369 citations

Blocking NO synthesis: how, where and why?

2002 • 323 citations

Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse

1992 • 320 citations

Antihyperalgesic effects of spinal cannabinoids

1998 • 282 citations

Update on the Neurophysiology of Pain Transmission and Modulation

2000 • 264 citations

Targeting the N-Methyl-d-Aspartate Receptor for Chronic Pain Management

2000 • 246 citations

NMDA receptors as targets for drug action in neuropathic pain

2001 • 229 citations

Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury

2000 • 229 citations

Spinal delivery of analgesics in experimental models of pain and analgesia

2003 • 209 citations

PDZ Protein Interactions Underlying NMDA Receptor-Mediated Excitotoxicity and Neuroprotection by PSD-95 Inhibitors

2007 • 195 citations

Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat

2008 • 186 citations

Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide.

1999 • 148 citations

NMDA Antagonists and Neuropathic Pain - Multiple Drug Targets and Multiple Uses

2005 • 146 citations

The PSD95–nNOS interface

2005 • 137 citations

Molecular Mechanisms Underlying Specificity of Excitotoxic Signaling in Neurons

2004 • 127 citations

Neuropathic Sensitization of Behavioral Reflexes and Spinal NMDA Receptor/CaM Kinase II Interactions Are Disrupted in PSD-95 Mutant Mice

2003 • 122 citations

Formation of nNOS/PSD-95 PDZ dimer requires a preformed β-finger structure from the nNOS PDZ domain

2000 • 117 citations

Genetic Knockout and Pharmacologic Inhibition of Neuronal Nitric Oxide Synthase Attenuate Nerve Injury-Induced Mechanical Hypersensitivity in Mice

2007 • 106 citations

Solution structure and backbone dynamics of the second PDZ domain of postsynaptic density-95

2000 • 100 citations

Nitric oxide mediates behavioral signs of neuropathic pain in an experimental rat model

1998 • 91 citations

Novel treatment of excitotoxicity: targeted disruption of intracellular signalling from glutamate receptors

2003 • 85 citations

Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats

2006 • 85 citations

The postsynaptic NMDA-receptor–PSD-95 signaling complex in excitatory synapses of the brain

2001 • 83 citations

Knockdown of PSD-95/SAP90 delays the development of neuropathic pain in rats

2001 • 74 citations

Expression of PSD-95/SAP90 is critical for N-methyl-d-aspartate receptor-mediated thermal hyperalgesia in the spinal cord

2000 • 68 citations

Pharmacodynamic and Pharmacokinetic Studies of Agmatine after Spinal Administration in the Mouse

2005 • 62 citations

Application of nitric oxide synthase inhibitor, Nω-nitro-l-arginine methyl ester, on injured nerve attenuates neuropathy-induced thermal hyperalgesia in rats

1996 • 49 citations

A Microtiter-Plate Assay of Human NOS Isoforms

2003 • 12 citations

Partner selection by PDZ domains

1997 • 9 citations