Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

Neuropathic pain: aetiology, symptoms, mechanisms, and management

1999 • 2,228 citations

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury

1990 • 1,819 citations

A method for measurement of analgesic activity on inflamed tissue.

1957 • 1,558 citations

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

2003 • 1,491 citations

Mechanisms of Neuropathic Pain

2006 • 1,336 citations

Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action

1999 • 1,148 citations

Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain

1988 • 996 citations

Spectrophotometric Determination of Serum Nitrite and Nitrate by Copper–Cadmium Alloy

2002 • 543 citations

Characterization of the novel nitric oxide synthase inhibitor 7‐nitro indazole and related indazoles: antinociceptive and cardiovascular effects

1993 • 470 citations

Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates

1998 • 432 citations

Comparison of three rodent neuropathic pain models

1997 • 407 citations

The Clinical Pharmacology of L-Arginine

2001 • 329 citations

Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse

1992 • 320 citations

Marked increase in nitric oxide synthase mRNA in rat dorsal root ganglia after peripheral axotomy: in situ hybridization and functional studies.

1992 • 289 citations

Nitric oxide synthase‐like immunoreactivity in lumbar dorsal root ganglia and spinal cord of rat and monkey and effect of peripheral axotomy

1993 • 210 citations

Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice

1999 • 209 citations

Neuropathic Pain Can Be Relieved by Drugs That Are Use-dependent Sodium Channel Blockers

1991 • 198 citations

The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive

1995 • 149 citations

Characterization of time course of spinal amino acids, citrulline and PGE2 release after carrageenan/kaolin-induced knee joint inflammation: a chronic microdialysis study

1996 • 140 citations

Local expression of inducible nitric oxide synthase in an animal model of neuropathic pain

1999 • 136 citations

Inhibition of nitric oxide synthesis inhibits rat sleep

1994 • 133 citations

Immunohistochemistry of nitric oxide synthase demonstrates immunoreactive neurons in spinal cord and dorsal root ganglia of man and rat

1993 • 133 citations

Treatment of a chronic allodynia-like response in spinally injured rats: effects of systemically administered nitric oxide synthase inhibitors

1996 • 126 citations

A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy

1996 • 121 citations

Functionally differentiating two neuronal nitric oxide synthase isoforms through antisense mapping: Evidence for opposing NO actions on morphine analgesia and tolerance

1997 • 121 citations

Nitroglycerin induces hyperalgesia in rats—a time-course study

2003 • 103 citations

The nitric oxide-cyclic GMP pathway is required for nociceptive signalling at specific loci within the somatosensory pathway

1996 • 90 citations

Neuropathic pain in rats is associated with altered nitric oxide synthase activity in neural tissue

1996 • 90 citations

Increased nitric oxide synthase immunoreactivity in rat dorsal root ganglia in a neuropathic pain model

1994 • 84 citations

Freehand cerebroventricular injection technique for unanesthetized rats

1971 • 82 citations

Substantial regional and hemispheric differences in brain nitric oxide synthase (NOS) inhibition following intracerebroventricular administration of Nω-nitro-l-arginine (L-NA) and its methyl ester (L-NAME)

1995 • 82 citations

Neuropathic pain is associated with alterations of nitric oxide synthase immunoreactivity and catalytic activity in dorsal root ganglia and spinal dorsal horn

2002 • 76 citations

Agmatine attenuates neuropathic pain in rats: Possible mediation of nitric oxide and noradrenergic activity in the brainstem and cerebellum

2003 • 69 citations

Role of Nitric Oxide in the Development of Thermal Hyperesthesia Induced by Sciatic Nerve Constriction Injury in the Rat

1995 • 49 citations

Application of nitric oxide synthase inhibitor, Nω-nitro-l-arginine methyl ester, on injured nerve attenuates neuropathy-induced thermal hyperalgesia in rats

1996 • 49 citations

Reduction of carrageenin oedema and the associated c‐Fos expression in the rat lumbar spinal cord by nitric oxide synthase inhibitor

1995 • 38 citations

Nitric oxide mediates neuropathic pain behavior in peripherally denervated rats

1995 • 36 citations

Spinal Nitric Oxide Mediates Antinociception from Intravenous Morphine

1998 • 33 citations

Oral administration of L-arginine potentiates allergen-induced airway inflammation and expression of interleukin-5 in mice.

1998 • 27 citations

Skin vascular reactivity to the neuropeptide substance P in rats with peripheral mononeuropathy

1993 • 26 citations

Stability and plasticity of nociceptor function and their relationship to provoked and ongoing pain

1995 • 25 citations

Managing post-herpetic neuralgia with opioids and local anesthetics

1994 • 24 citations

Effect of 7‐nitro indazole on neurotransmission in the rat vas deferens: mechanisms unrelated to inhibition of nitric oxide synthase

1994 • 21 citations

Systemic N‐nitro‐L‐arginine‐ester (L‐NAM E), inhibitor of nitric oxide synthase, relieves chronic allodynia‐like symptom in rats with spinal cord lesion

1994 • 21 citations

Involvement of the nitric oxide pathway in nociceptive processes in the central nervous system in rats

1994 • 15 citations

The role of nitric oxide in neuropathic pain and neurodegeneration

1998 • 9 citations

Role of central Nitrinergic system in experimentally Induced inflammation and Nociception in Rats

2000 • 1 citations