Pharmacodynamic and Pharmacokinetic Studies of Agmatine after Spinal Administration in the Mouse

Intrathecal morphine in mice: A new technique

1980 • 1,880 citations

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

1991 • 1,212 citations

Agmatine: an Endogenous Clonidine-Displacing Substance in the Brain

1994 • 727 citations

Drug Synergism and Dose-Effect Data Analysis

2000 • 554 citations

Characterization of the novel nitric oxide synthase inhibitor 7‐nitro indazole and related indazoles: antinociceptive and cardiovascular effects

1993 • 470 citations

Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats

1993 • 400 citations

A potential role for excitotoxins in the pathophysiology of spinal cord injury

1988 • 377 citations

Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.

1987 • 373 citations

Naphthalene-2,3-dicarboxyaldehyde/cyanide ion: a rationally designed fluorogenic reagent for primary amines

1987 • 332 citations

Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse

1992 • 320 citations

Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine

1996 • 310 citations

Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy

1992 • 286 citations

Agmatine selectively blocks the N-methyl-D-aspartate subclass of glutamate receptor channels in rat hippocampal neurons.

1999 • 256 citations

Agmatine, the bacterial amine, is widely distributed in mammalian tissues

1995 • 248 citations

Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury

2000 • 229 citations

Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614.

1993 • 214 citations

Spinal delivery of analgesics in experimental models of pain and analgesia

2003 • 209 citations

Cholecystokinin in the Rostral Ventromedial Medulla Mediates Opioid-Induced Hyperalgesia and Antinociceptive Tolerance

2005 • 204 citations

Modulation of opioid analgesia by agmatine

1996 • 152 citations

Selective Inhibition of Inducible Nitric Oxide Synthase by Agmatine

1995 • 147 citations

Determination of agmatine in brain and plasma using high-performance liquid chromatography with fluorescence detection

1997 • 102 citations

Acute tolerance to spinally administered morphine compares mechanistically with chronically induced morphine tolerance.

1997 • 89 citations

Effects of agmatine on the escalation of intravenous cocaine and fentanyl self-administration in rats

2002 • 86 citations

Agmatine recognizes ?2-adrenoceptor binding sites but neither activates nor inhibits ?2-adrenoceptors

1995 • 84 citations

Agmatine Crosses the Blood‐Brain Barrier

2003 • 70 citations

Agmatine: A Novel Neurotransmitter?

1997 • 57 citations

In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence.

2001 • 56 citations

Low-affinity NMDA receptor channel blockers inhibit acquisition of intravenous morphine self-administration in naive mice

1999 • 51 citations

Effect of intrathecal agmatine on inflammation-induced thermal hyperalgesia in rats

1999 • 45 citations

Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine‐mediated blood pressure reaction

2002 • 44 citations

Neuropharmacokinetic and Dynamic Studies of Agmatine (Decarboxylated Arginine)

2003 • 41 citations

Alpha2-adrenoceptors vs. imidazoline receptors: implications for α2-mediated analgesia and other non-cardiovascular therapeutic uses

1995 • 40 citations

Graded dose—response

1987 • 34 citations

Spinal antinociceptive effect of agmatine and tentative analysis of involved receptors: study in an electrophysiological model of rats

2003 • 19 citations

Deleted Work

1955 • 0 citations