Application of nitric oxide synthase inhibitor, Nω-nitro-l-arginine methyl ester, on injured nerve attenuates neuropathy-induced thermal hyperalgesia in rats

Ethical guidelines for investigations of experimental pain in conscious animals

1983 • 7,639 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1988 • 4,963 citations

Nitric oxide (NO) and nociceptive processing in the spinal cord

1993 • 958 citations

Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse

1992 • 320 citations

Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nociceptive tail-flick reflex

1992 • 281 citations

The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release

1991 • 267 citations

The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat

1994 • 230 citations

Inhibition of nitric oxide synthase enhances morphine antinociception in the rat spinal cord

1993 • 157 citations

Endogenous and exogenous modulation of gap junctional intercellular communication: Toxicological and pharmacological implications

1993 • 139 citations

Nitric oxide evokes pain in humans on intracutaneous injection

1994 • 111 citations

Nitric oxide mediates ongoing discharges in dorsal root ganglion cells after peripheral nerve injury

1993 • 72 citations

Nerve growth factor alleviates a painful peripheral neuropathy in rats

1995 • 67 citations

Role of Nitric Oxide in the Development of Thermal Hyperesthesia Induced by Sciatic Nerve Constriction Injury in the Rat

1995 • 49 citations

Increase of nitric oxide production by L-arginine potentiates i.c.v. administered β-endorphin-induced antinociception in the mouse

1992 • 47 citations

Systemic N‐nitro‐L‐arginine‐ester (L‐NAM E), inhibitor of nitric oxide synthase, relieves chronic allodynia‐like symptom in rats with spinal cord lesion

1994 • 21 citations