Mechanism of hepatocellular dysfunction during hyperdynamic sepsis

Sepsis and septic shock—A review of laboratory models and a proposal

1980 • 1,441 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.

1989 • 1,183 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever

1990 • 765 citations

Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia.

1989 • 651 citations

Elevation of Cardiac Output and Oxygen Delivery Improves Outcome in Septic Shock

1992 • 555 citations

Laboratory models of sepsis and septic shock

1990 • 539 citations

Cytokine appearance in human endotoxemia and primate bacteremia.

1988 • 528 citations

Multiple, Progressive, or Sequential Systems Failure

1975 • 478 citations

Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings

1989 • 365 citations

Effect of sepsis on tissue adenine nucleotide levels.

1979 • 329 citations

Plasma tumor necrosis factor and mortality in critically ill septic patients

1989 • 324 citations

Endotoxin, tumor necrosis factor-α and interleukin 1 induce interleukin 6 production in vivo

1989 • 298 citations

An overview of mortality risk prediction in sepsis

1995 • 251 citations

Serum cachectin/tumor necrosis factor in critically ill patients with burns correlates with infection and mortality.

1990 • 217 citations

Endotoxin-induced cytokine gene expression and excretion in the liver

1994 • 213 citations

Cardiac output and redistribution of organ blood flow in hypermetabolic sepsis

1984 • 171 citations

Cellular mechanisms in shock and ischemia and their correction

1983 • 153 citations

Estimation of the Functional Reserve of Human Liver

1974 • 131 citations

Blockade of liver macrophages by gadolinium chloride reduces lethality in endotoxemic rats—analysis of mechanisms of lethality in endotoxemia

1994 • 123 citations

Recombinant Human Tumor Necrosis Factor Produces Hemodynamic Changes Characteristic of Sepsis and Endotoxemia

1989 • 115 citations

Monoclonal antibody to tumor necrosis factor--alpha prevents lethal endotoxin sepsis in adult rhesus monkeys.

1992 • 112 citations

ROLE OF KUPFFER CELLS IN INTERLEUKIN-6 RELEASE FOLLOWING TRAUMA-HEMORRHAGE AND RESUSCITATION

1994 • 111 citations

Hepatic Extraction of Indocyanine Green Is Depressed Early in Sepsis Despite Increased Hepatic Blood Flow and Cardiac Output

1991 • 106 citations

Sepsis and its complications: the clinical problem.

1994 • 104 citations

MULTIPLE ORGAN FAILURE, MULTIPLE ORGAN DYSFUNCTION SYNDROME, AND THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME—WHERE DO WE STAND?

1994 • 99 citations

Modulation of Macrophage Hyperactivity Improves Survival in a Burn-Sepsis Model

1992 • 93 citations

Hepatocellular dysfunction occurs early after hemorrhage and persists despite fluid resuscitation

1990 • 87 citations

Indocyanine Green

1984 • 86 citations

Pentoxifylline decreases body weight loss and muscle protein wasting characteristics of sepsis

1993 • 78 citations

Effective organ blood flow and bioenergy status in murine peritonitis.

1986 • 74 citations

Tumor necrosis factor-alpha produces hepatocellular dysfunction despite normal cardiac output and hepatic microcirculation

1993 • 74 citations

Continuous infusion of endotoxin from an osmotic pump in the conscious, unrestrained rat: a unique model of chronic endotoxemia.

1984 • 72 citations

Cellular Distribution of Endotoxin after Injection of Chemically Purified Lipopolysaccharide Differs from That after Injection of Live Bacteria

1994 • 65 citations

Pentoxifylline in the Treatment of Experimental Peritonitis in Rats

1985 • 63 citations

Differential alterations in microvascular perfusion in various organs during early and late sepsis

1992 • 63 citations

Tissue Tumor Necrosis Factor mRNA Expression Following Cecal Ligation and Puncture or Intraperitoneal Injection of Endotoxin

1994 • 62 citations

HEPATOCELLULAR DYSFUNCTION OCCURS EARLIER THAN THE ONSET OF HYPERDYNAMIC CIRCULATION DURING SEPSIS

1995 • 60 citations

Sequential changes in the splanchnic circulation during continuous endotoxin infusion in sedated sheep: evidence for a selective increase of hepatic artery blood flow and loss of the hepatic arterial buffer response

1993 • 60 citations

Nitric Oxide

1994 • 59 citations

Efficacy of monoclonal antibody against tumor necrosis factor alpha in an endotoxemic baboon model.

1992 • 58 citations

Preheparinization improves organ function after hemorrhage and resuscitation

1990 • 54 citations

Altered Hepatocellular Active Transport

1982 • 51 citations

Hepatic Parenchymal Oxygen Tension Following Injury and Sepsis

1990 • 50 citations

Tumor Necrosis Factor and Interleukin 1 Appearance in Experimental Gram-negative Septic Shock

1991 • 48 citations

Regulation of tumor necrosis factor-α-mRNA synthesis and distribution of tumor necrosis factor-α-mRNA synthesizing cells in rat liver during experimental endotoxemia

1994 • 47 citations

Estimation of Functional Hepatic Mass in Resected and Regenerating Rat Liver

1974 • 37 citations

Tumor necrosis factor production by Kupffer cells requires protein kinase C activation

1990 • 37 citations

ANTI-TUMOR NECROSIS FACTOR ANTIBODY TREATMENT OF RECURRENT BACTEREMIA IN A BABOON MODEL

1994 • 37 citations

Sepsis-induced cascade of cytokine mRNA expression: correlation with metabolic changes

1992 • 33 citations

Temporal Relationship of Hepatocellular Dysfunction and Ischemia in Sepsis

1988 • 31 citations

The Mechanism of Hepatic Cellular Injury in Sepsis: An in Vitro Study of the Implications of Cytokines and Neutrophils in Its Pathogenesis

1993 • 31 citations

Hepatocellular Dysfunction Persists During Early Sepsis Despite Increased Volume of Crystalloid Resuscitation

1992 • 28 citations

Intestinal bacterial flora, intestinal pathology, and lipopolysaccharide-induced translocation of intestinal bacteria.

1992 • 27 citations

Effective hepatic blood flow and hepatic bioenergy status in murine peritonitis

1987 • 25 citations

Enhancement of hepatic macrophages in septic rats and their inhibitory effect on hepatocyte function

1991 • 23 citations

Alterations in circulating blood volume during polymicrobial sepsis.

1993 • 23 citations

Immunologic activation of hepatic macrophages in septic rats: a possible mechanism of sepsis-associated liver injury.

1994 • 21 citations

Effect of different sepsis-related cytokines on lipid synthesis by isolated hepatocytes

1994 • 20 citations

Rodent Models of Endotoxemia and Sepsis

1993 • 20 citations

Disappearance of indocyanine green during circulatory shock.

1973 • 20 citations

Enhancement and hepatocyte-modulating effect of chemical mediators and monokines produced by hepatic macrophages in rats with induced sepsis

1991 • 19 citations

Energy state, glycolytic intermediates and mitochondrial function in the liver during reversible and irreversible endotoxin shock.

1989 • 18 citations

Sepsis in the young rat: maternal milk protects during cecal ligation and puncture sepsis but not during endotoxemia.

1991 • 15 citations

Chronic hyperdynamic sepsis in the rat: I. Characterization of the animal model.

1988 • 15 citations

Modulation of protein kinase C alters hemodynamics and metabolism in the isolated liver in fed and fasted rats

1993 • 12 citations

Correction of hepatocellular dysfunction during endotoxemia

1978 • 10 citations

Effect of ischemia on protein synthesis in the septic liver.

1991 • 9 citations

Hepatic drug disposition in multiple organ failure

1988 • 4 citations