Delayed secondary glucocorticoid response elements. Unusual nucleotide motifs specify glucocorticoid receptor binding to transcribed regions of alpha 2u-globulin DNA.

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS

1985 • 1,911 citations

Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

1980 • 1,884 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

1990 • 993 citations

E. coli RNA polymerase interacts homologously with two different promoters

1980 • 911 citations

Gene regulation by proteins acting nearby and at a distance

1986 • 886 citations

Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.

1988 • 736 citations

Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region

1983 • 700 citations

DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo

1983 • 692 citations

The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements

1988 • 679 citations

GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

1990 • 677 citations

Temporal Control of Puffing Activity in Polytene Chromosomes

1974 • 632 citations

Solution Structure of the Glucocorticoid Receptor DNA-Binding Domain

1990 • 609 citations

Modular structure of a chicken lysozyme silencer: Involvement of an unusual thyroid hormone receptor binding site

1990 • 487 citations

Intracellular Receptor Concentration Limits Glucocorticoid-Dependent Enhancer Activity*

1987 • 363 citations

Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment whose transcription is regulated by glucocorticoids in vivo.

1981 • 341 citations

Pyrimidine-specific chemical reactions useful for DNA sequencing

1980 • 326 citations

DNA regulatory elements for steroid hormones

1989 • 305 citations

Prolactin and glucocorticoid hormones synergistically induce expression of transfected rat beta-casein gene promoter constructs in a mammary epithelial cell line.

1989 • 257 citations

ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase.

1990 • 254 citations

Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory element of mouse mammary tumor virus.

1984 • 247 citations

Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities.

1989 • 240 citations

Mutations of the Rat Growth Hormone Promoter which Increase and Decrease Response to Thyroid Hormone Define a Consensus Thyroid Hormone Response Element

1989 • 240 citations

Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene.

1985 • 235 citations

Transcriptional control by nuclear receptors

1991 • 234 citations

Interaction of the glucocorticoid receptor DNA-binding domain with DNA as a dimer is mediated by a short segment of five amino acids.

1991 • 225 citations

Down-regulation and Phosphorylation of Glucocorticoid Receptors in Cultured Cells

1989 • 223 citations

The first intron of the human growth hormone gene contains a binding site for glucocorticoid receptor.

1985 • 215 citations

Steroid hormone receptors : structure and function

1983 • 210 citations

Identification of phosphorylated sites in the mouse glucocorticoid receptor.

1991 • 208 citations

Structural Determinants of a Glucocorticoid Receptor Recognition Element

1990 • 201 citations

Molecular interactions within the ecdysone regulatory hierarchy: DNA binding properties of the Drosophila ecdysone-inducible E74A protein

1990 • 195 citations

Dexamethasone regulation of alpha 1-acid glycoprotein and other acute phase reactants in rat liver and hepatoma cells.

1983 • 194 citations

A bacteriophage RNA polymerase transcribes through a Xenopus 5S RNA gene transcription complex without disrupting it

1986 • 169 citations

The Purified Activated Glucocorticoid Receptor is a Homodimer

1989 • 156 citations

Reversible phosphorylation of an enhancer binding protein regulates the transcription of bacterial nitrogen utilization genes

1988 • 152 citations

Protein-protein interactions facilitate DNA binding by the glucocorticoid receptor DNA-binding domain.

1990 • 128 citations

The missing nucleoside experiment: a new technique to study recognition of DNA by protein

1989 • 94 citations

Multiple specific binding sites for purified glucocorticoid receptors on mammary tumor virus DNA

1982 • 90 citations

Sequences Downstream of the Glucocorticoid Regulatory Element Mediate Cycloheximide Inhibition of Steroid Induced Expression from the Rat α₁-Acid Glycoprotein Promoter: Evidence for a Labile Transcription Factor

1988 • 87 citations

Rat alpha 1-acid glycoprotein. Gene sequence and regulation by glucocorticoids in transfected L-cells.

1985 • 84 citations

Efficient Binding of Glucocorticoid Receptor to Its Responsive Element Requires a Dimer and DNA Flanking Sequences

1990 • 79 citations

Stoichiometric analysis of the specific interaction of the glucocorticoid receptor with DNA.

1986 • 79 citations

Bacterial gene regulation from distant DNA sites

1989 • 72 citations

The Structure and Function of Steroid Receptor Protein

1989 • 70 citations

The structure and expression of very closely related members of the alpha 2u globulin gene family.

1982 • 64 citations

Thyroid Hormone Receptors Repress Estrogen Receptor Activation of a TRE

1991 • 62 citations

Developmental and hormonal regulation of alpha 2u-globulin gene transcription.

1985 • 59 citations

A dynamic model of glucocorticoid receptor phosphorylation and cycling in intact cells

1989 • 57 citations

RNA and protein synthesis in the cellular response to a hormone, ecdysone.

1966 • 56 citations

Nucleotide Sequences Required for the Regulation of a Rat α_2u-Globulin Gene by Glucocorticoids

1986 • 55 citations

Steroid receptors

1989 • 44 citations

A model for hormone receptor binding to the mouse mammary tumour virus regulatory element bared on hydroxyl radical footprinting

1988 • 35 citations

Ecdysteroid‐regulated gene expression in Drosophila melanogaster

1988 • 25 citations

Activation of an Enhancerless Gene by Chromosomal Integration

1986 • 22 citations

HORMONAL CONTROL OF α_2u GLOBULIN SYNTHESIS AND ITS mRNA IN ISOLATED HEPATOCYTES

1980 • 20 citations

Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment that mediates a delayed secondary response to glucocorticoids in vivo.

1990 • 18 citations

Identification of Nuclear Proteins That Bind to the Glucocorticoid Regulatory Region of a Rat α2u-Globulin Gene

1989 • 18 citations

Multihormonal induction of α_2u‐globulin in an established rat hepatoma cell line

1982 • 16 citations

Nuclear Factors from Expressing Tissues Interact in Vitro with a Rat α-2u Globulin Gene Intron

1989 • 10 citations

DNA Sequences Required for Hormonal Induction of Rat 2u-globulin Genes

1983 • 10 citations

Glucocorticoid receptor binding to defined regions of α2 u-globulin genes

1987 • 9 citations

A Conceptual View of Transcriptional Regulation

1989 • 9 citations

Developmentally Regulated Male-Specific Transfactor(s) Enablein VitroTranscription of a Cloned α_2U-Globulin Gene

1989 • 8 citations

A LINE 1 sequence interrupts the rat α2u globulin gene

1989 • 6 citations