A dynamic model of glucocorticoid receptor phosphorylation and cycling in intact cells

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

1984 • 3,073 citations

STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS

1985 • 1,911 citations

Facilitated Target Location in Biological Systems

1989 • 1,011 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Steroid Receptors: Elements for Modulation of Eukaryotic Transcription

1976 • 688 citations

Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation

1988 • 600 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

Steroid hormone receptors compete for factors that mediate their enhancer function

1989 • 580 citations

Nuclear protein migration involves two steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores

1988 • 551 citations

Nuclear import can be separated into distinct steps in vitro: Nuclear pore binding and translocation

1988 • 535 citations

A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor

1988 • 427 citations

Biochemistry, Molecular Biology, and Physiology of the Glucocorticoid Receptor*

1987 • 409 citations

Evidence That the 90-kDa Heat Shock Protein Is Necessary for the Steroid Binding Conformation of the L Cell Glucocorticoid Receptor

1989 • 394 citations

Specific and Nonspecific Physicochemical Interactions of Glucocorticoids and Related Steroids with Rat Thymus Cells in Vitro

1968 • 381 citations

Regulation of Glucocorticoid Receptor Expression: Evidence for Transcriptional and Posttranslational Mechanisms

1988 • 311 citations

Relationship of the 90-kDa murine heat shock protein to the untransformed and transformed states of the L cell glucocorticoid receptor.

1987 • 267 citations

A region in the steroid binding domain determines formation of the non-DNA-binding, 9 S glucocorticoid receptor complex.

1988 • 267 citations

Characterization of a Monoclonal Antibody to the Rat Liver Glucocorticoid Receptor*

1984 • 263 citations

A 59-kilodalton protein associated with progestin, estrogen, androgen, and glucocorticoid receptors

1986 • 261 citations

Molybdate-stabilized nonactivated glucocorticoid-receptor complexes contain a 90-kDa non-steroid-binding phosphoprotein that is lost on activation.

1986 • 233 citations

Activation of the glucocorticoid-receptor complex

1982 • 224 citations

Glucocorticoid-receptor complexes and the earliest steps in the action of glucocorticoids on thymus cells

1972 • 206 citations

Direct demonstration of glucocorticoid receptor phosphorylation by intact L-cells.

1983 • 200 citations

Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II

1989 • 190 citations

Immunological evidence that the nonhormone binding component of avian steroid receptors exists in a wide range of tissues and species

1985 • 188 citations

Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro

1987 • 179 citations

Domains of the Glucocorticoid Receptor Involved in Specific and Nonspecific Deoxyribonucleic Acid Binding, Hormone Activation, and Transcriptional Enhancement

1987 • 174 citations

Calmodulin-regulated binding of the 90-kDa heat shock protein to actin filaments.

1986 • 165 citations

Receptors bound to antiprogestin form abortive complexes with hormone responsive elements

1988 • 164 citations

The molybdate-stabilized L-cell glucocorticoid receptor isolated by affinity chromatography or with a monoclonal antibody is associated with a 90-92-kDa nonsteroid-binding phosphoprotein.

1985 • 156 citations

Steroid-binding properties and stabilization of cytoplasmic glucocorticoid receptors from rat thymus cells

1973 • 155 citations

Triamcinolone acetonide regulates glucocorticoid-receptor levels by decreasing the half-life of the activated nuclear-receptor form.

1985 • 150 citations

Glucocorticoid receptors and actions.

1990 • 132 citations

Agonist-dependent phosphorylation and nuclear dephosphorylation of glucocorticoid receptors in intact cells

1989 • 126 citations

Identification of cysteine 656 as the amino acid of hepatoma tissue culture cell glucocorticoid receptors that is covalently labeled by dexamethasone 21-mesylate.

1987 • 125 citations

Evidence for intracellular association of the glucocorticoid receptor with the 90-kDa heat shock protein.

1988 • 124 citations

Interaction of the Mr = 90,000 heat shock protein with the steroid-binding domain of the glucocorticoid receptor.

1988 • 123 citations

Identification of hormone-interacting amino acid residues within the steroid-binding domain of the glucocorticoid receptor in relation to other steroid hormone receptors.

1988 • 121 citations

Domain structure of the glucocorticoid receptor protein.

1987 • 121 citations

Isoform composition and stoichiometry of the approximately 90-kDa heat shock protein associated with glucocorticoid receptors.

1988 • 114 citations

Regulation Of Gene Expression By Glucocorticoids

1989 • 110 citations

Two cellular proteins that immunoprecipitate with the transforming protein of Rous sarcoma virus

1981 • 110 citations

Glucocorticoid-receptor complexes in rat thymus cells. Rapid kinetic behavior and a cyclic model.

1984 • 108 citations

Steady-state level of the specific glucocorticoid binding component in mouse fibroblasts

1972 • 100 citations

Glucocorticoid receptors lacking hormone-binding activity are bound in nuclei of ATP-depleted cells

1986 • 95 citations

Phosphorylation of rat liver glucocorticoid receptor.

1985 • 94 citations

Molecular Mechanism of Steroid Hormone Action

1985 • 94 citations

Glucocorticoid receptor phosphorylation, transformation, and DNA binding.

1987 • 86 citations

Molybdate-stabilized glucocorticoid receptor: evidence for a receptor heteromer

1985 • 81 citations

Phosphorylation of rat hepatic glucocorticoid receptor

1984 • 78 citations

Immunologic analysis of human breast cancer progesterone receptors. 2. Structure, phosporylation, and processing

1987 • 75 citations

Interaction of the glucocorticoid receptor with the Mr 90,000 heat shock protein: an evolving model of ligand-mediated receptor transformation and translocation.

1989 • 74 citations

Heteromeric nature of glucocorticoid receptor

1985 • 71 citations

Localization of phosphorylation sites with respect to the functional domains of the mouse L cell glucocorticoid receptor.

1988 • 70 citations

Purification and structural analysis of the modulator of the glucocorticoid-receptor complex. Evidence that modulator is a novel phosphoglyceride.

1988 • 60 citations

Hormone-Dependent Phosphorylation of the Avian Progesterone Receptor

1988 • 59 citations

Activation of cytosolic glucocorticoid-receptor complexes in intact WEHI-7 cells does not dephosphorylate the steroid-binding protein.

1987 • 57 citations

Subunit composition of the estrogen receptor

1989 • 48 citations

Hormone-dependent phosphorylation of the avian progesterone receptor.

1988 • 47 citations

Identification of cysteine-644 as the covalent site of attachment of dexamethasone 21-mesylate to murine glucocorticoid receptors in WEHI-7 cells

1988 • 46 citations

Characterization of purified avian 90,000-Da heat shock protein

1988 • 41 citations

Phosphorylation of the chicken progesterone receptor

1987 • 38 citations

Tetrameric structure of the nonactivated glucocorticoid receptor in cell extracts and intact cells

1988 • 37 citations

Phosphorylation of glucocorticoid receptor-associated and free forms of the ∼90-kDa heat shock protein before and after receptor activation

1989 • 34 citations

Evidence that the endogenous heat-stable glucocorticoid receptor stabilizing factor is a metal component of the untransformed receptor complex.

1988 • 32 citations

Phosphorylated sites within the functional domains of the .apprx.100-kDa steroid-binding subunit of glucocorticoid receptors

1989 • 30 citations

Investigation of protein structure by means of ¹⁹F‐NMR

1988 • 30 citations

Inactivation, Activation, and Stabilization of Glucocorticoid Receptors

1984 • 27 citations

Degradation without apparent change in size of molybdate-stabilized nonactivated glucocorticoid-receptor complexes in rat thymus cytosol.

1985 • 26 citations

Multiple forms of nuclear binding of glucocorticoid-receptor complexes in rat thymocytes

1980 • 25 citations

Absence of detectable ribonucleic acid in the purified, untransformed mouse glucocorticoid receptor

1986 • 24 citations

A possible role for dephosphorylation in glucocorticoid receptor transformation

1987 • 23 citations

Interaction of RNA with transformed glucocorticoid receptor. II. Identification of the RNA as transfer RNA.

1987 • 22 citations

Molecular endocrinology and steroid hormone action

1990 • 18 citations

Steroid receptor recycling and its possible role in the modulation of steroid hormone action

1984 • 16 citations

Association of RNA with the Glucocorticoid Receptor and Possible Role in Activation

1986 • 10 citations

Evidence for a glucocorticoid receptor cycle and nuclear dephosphorylation of the steroid-binding protein.

1990 • 8 citations

Examination of Exchange Assay for Glucocorticoid Receptor.

1987 • 5 citations

The effect of alkaline phosphatase on the activation of glucocorticoid-receptor complexes in rat liver cytosol

1986 • 4 citations