Immunological Surveillance of Tumors in the Context of Major Histocompatibility Complex Restriction of T Cell Function

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1983 • 6,811 citations

Pneumocystis cariniiPneumonia and Mucosal Candidiasis in Previously Healthy Homosexual Men

1981 • 2,717 citations

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

Natural Killer Cells: Their Roles in Defenses Against Disease

1981 • 1,353 citations

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

1984 • 1,262 citations

Isolation of Human T-Cell Leukemia Virus in Acquired Immune Deficiency Syndrome (AIDS)

1983 • 1,222 citations

Histocompatibility-Linked Immune Response Genes

1972 • 1,194 citations

Biology of the Mouse Histocompatibility-2 Complex

1975 • 1,145 citations

Natural Cell-Mediated Immunity

1978 • 1,063 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

The somatic generation of immune recognition

1971 • 974 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

1983 • 861 citations

Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis

1974 • 832 citations

Disseminated Kaposi's Sarcoma in Homosexual Men

1982 • 729 citations

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1984 • 719 citations

Genetic Control of Specific Immune Responses

1969 • 681 citations

Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon.

1983 • 638 citations

H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.

1975 • 623 citations

Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive drugs.

1979 • 600 citations

Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

1983 • 586 citations

Natural Killer Cells: Characteristics and Regulation of Activity

1979 • 582 citations

T Cell Control of Antibody Production

1974 • 582 citations

Cell‐mediated cytotoxicity to trinitrophenyl‐modified syngeneic lymphocytes

1974 • 572 citations

HLA and Disease 1982 ‐ A Survey

1983 • 551 citations

Cellular and Humoral Aspects of the Hypersensitive States

1959 • 549 citations

Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody.

1982 • 526 citations

Evolutionary Significance of the HL-A System

1972 • 523 citations

Gene conversion: Some implications for immunoglobulin genes

1981 • 496 citations

A BIOLOGICAL ROLE FOR THE MAJOR HISTOCOMPATIBILITY ANTIGENS

1975 • 488 citations

A hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes.

1978 • 488 citations

Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon

1983 • 487 citations

Molecular mechanisms of variation in influenza viruses

1982 • 484 citations

In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.

1975 • 454 citations

Genetic Control Of Murine Viral Leukemogenesis

1973 • 452 citations

Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

1983 • 441 citations

Clusters of genes encoding mouse transplantation antigens

1982 • 419 citations

Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation.

1983 • 400 citations

Preferential effect of γ interferon on the synthesis of HLA antigens and their mRNAs in human cells

1982 • 386 citations

T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor.

1980 • 373 citations

Antibodies to Cell Membrane Antigens Associated with Human T-Cell Leukemia Virus in Patients with AIDS

1983 • 353 citations

Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunity

1983 • 353 citations

Study of antibodies against human melanoma produced by somatic cell hybrids.

1978 • 349 citations

Expression and Function of Idiotypes on Lymphocytes

1978 • 340 citations

Two-gene control of the expression of a murine Ia antigen.

1978 • 328 citations

Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes

1981 • 327 citations

Interaction Between Antigen‐Presenting Cells and Primed T Lymphocytes

1978 • 303 citations

Lymphoma development in mice and humans: diversity of initiation is followed by convergent cytogenetic evolution.

1979 • 302 citations

Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication.

1983 • 300 citations

Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice.

1978 • 296 citations

Biology of the Laboratory Mouse

1967 • 296 citations

Immunologic Mechanisms in UV Radiation Carcinogenesis

1981 • 295 citations

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid.

1983 • 293 citations

Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H‐2‐Restriction‐Specificity and in H‐2 Linked Ir Gene Control

1978 • 291 citations

Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses.

1977 • 285 citations

Opinion

1978 • 283 citations

The genes of influenza virus

1977 • 278 citations

QUANTITATIVE STUDIES ON THE MIXED LYMPHOCYTE INTERACTION IN RATS

1968 • 274 citations

HLA‐DR Antigens: Structure, Separation of Subpopulations, Gene Cloning and Function

1982 • 258 citations

The Influence of Thymus H-2 Antigens on the Specificity of Maturing Killer and Helper Cells

1978 • 257 citations

Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.

1982 • 252 citations

Escape of mouse mastocytoma P815 after nearly complete rejection is due to antigen-loss variants rather than immunosuppression.

1983 • 251 citations

Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.

1983 • 245 citations

Proviral DNA of a Retrovirus, Human T-Cell Leukemia Virus, in Two Patients with AIDS

1983 • 244 citations

The fine specificity of antigen and la determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c

1982 • 244 citations

Patterns of gene expression and the cellular origins of human leukaemias

1978 • 242 citations

Genes of the Major Histocompatibility Complex in Mouse and Man

1983 • 241 citations

Antigen-Binding, Idiotypic T-Lymphocyte Receptors

1977 • 230 citations

Interaction antigens detected by cytotoxic T cells with the major histocompatibility complex as modifier

1975 • 229 citations

Cytotoxic T cells kill influenza virus infected cells but do not distinguish between serologically distinct type A viruses

1977 • 229 citations

Skin cancer in Caucasian renal allograft recipients living in a subtropical climate.

1980 • 229 citations

Expression of Ia-like antigen molecules on human granulocytes during early phases of differentiation

1977 • 228 citations

Contrasuppression. A novel immunoregulatory activity.

1981 • 227 citations

Human T-cell clones recognize chemically synthesized peptides of influenza haemagglutinin

1982 • 224 citations

Structure and expression of a mouse major histocompatibility antigen gene, H-2Ld.

1982 • 223 citations

Genetics of histocompatibility in mice

1975 • 217 citations

Responsiveness to HY Antigen Ir Gene Complementation and Target Cell Specificity

1977 • 215 citations

Suppression of in vitro Epstein-Barr virus infection. A new role for adult human T lymphocytes.

1977 • 210 citations

Expression of influenza A virus internal antigens on the surface of infected P815 cells.

1981 • 206 citations

Immune interferon release when a cloned cytotoxic T-cell line meets its correct influenza-infected target cell

1982 • 202 citations

H-2 Mutations: Their Genetics and Effect on Immune Functions

1978 • 200 citations

Primary Structural Analysis of the Transplantation Antigens of the Murine H-2 Major Histocompatibility Complex

1981 • 196 citations

Primary structure of a murine transplantation antigen

1981 • 194 citations

Identification and molecular cloning of the human Blym transforming gene activated in Burkitt's lymphomas

1983 • 192 citations

An immunological suppressor cell inactivating cytotoxic T-lymphocyte precursor cells recognizing it

1980 • 190 citations

Spontaneous H-2 mutants provide evidence that a copy mechanism analogous to gene conversion generates polymorphism in the major histocompatibility complex.

1983 • 188 citations

The Histocompatibility-Linked Immune Response Genes

1975 • 186 citations

BIOCHEMISTRY OF THE GENE PRODUCTS FROM MURINE MHC MUTANTS

1980 • 182 citations

Evolution of influenza A and B viruses: conservation of structural features in the hemagglutinin genes.

1982 • 181 citations

Two Different V_H Gene Products Make Up the T‐Cell Receptors

1976 • 179 citations

HOST GENETIC CONTROL OF RECOVERY FROM FRIEND LEUKEMIA VIRUS-INDUCED SPLENOMEGALY

1974 • 172 citations

Phenotypic and Cytogenetic Characteristics of Human B-Lymphoid Cell Lines and Their Relevance for the Etiology of Burkitt'S Lymphoma

1982 • 172 citations

Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins

1982 • 168 citations

Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype.

1978 • 166 citations

Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness.

1978 • 166 citations

Identification of the Receptor for Antigen and Major Histocompatibility Complex on Human Inducer T Lymphocytes

1983 • 165 citations

Functional interactions of viral and histocompatibility antigens at tumor cell surfaces.

1975 • 165 citations

Suppressor Cells: Permitters and Promoters of Malignancy?

1979 • 162 citations

A Clonal Deletion Model for Ir Gene Control of the Immune Response

1978 • 156 citations

THE EFFECT OF HISTOCOMPATIBILITY-2 TYPE ON RESPONSE TO THE FRIEND LEUKEMIA VIRUS IN MICE

1968 • 156 citations

Killer cells reactive to altered-self antigens can also be alloreactive.

1977 • 155 citations

Major histocompatibility complex-restricted antigen presentation to antigen-reactive T cells by B lymphocyte tumor cells.

1981 • 153 citations

Molecular association between transplantation antigens and cell surface antigen in adenovirus-transformed cell line.

1978 • 151 citations

Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells.

1978 • 151 citations

Differential expression of H–2 gene products in tumour cells is associated with their metastatogenic properties

1980 • 146 citations

A one-receptor view of T-cell behaviour

1981 • 146 citations

HLA-restricted T-cell recognition of Epstein–Barr virus-infected B cells

1980 • 146 citations

ACQUIRED IMMUNODEFICIENCY SYNDROME IS AN OPPORTUNISTIC INFECTION AND KAPOSI'S SARCOMA RESULTS FROM SECONDARY IMMUNE STIMULATION

1983 • 144 citations

Strong and Weak Histocompatibility Gene Differences in Mice and Their Role in the Rejection of Homografts of Tumors and Skin

1956 • 143 citations

Specificity of cytotoxic T cells from athymic mice.

1980 • 141 citations

Clonal analysis of cytotoxic T cell response against human melanoma.

1983 • 138 citations

Expression of Ia-like antigens on cultured human malignant melanoma cell lines.

1978 • 137 citations

An Analysis of Effector T Cell Generation and Function in Mice Exposed to Influenza A or Sendai Viruses

1981 • 137 citations

Genetic mapping in the major histocompatibility complex by restriction enzyme site polymorphisms: most mouse class I genes map to the Tla complex.

1983 • 136 citations

Chromosomal Abnormalities and Their Specificity in Human Neoplasms: An Assessment of Recent Observations by Banding Techniques

1977 • 134 citations

Reversible induction of natural killer cell activity in cloned murine cytotoxic T lymphocytes

1983 • 134 citations

Immune response gene control of determinant selection. I. Intramolecular mapping of the immunogenic sites on insulin recognized by guinea pig T and B cells.

1977 • 133 citations

Murine T Lymphocyte Clones with Distinct Immunological Functions

1981 • 133 citations

Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures.

1983 • 133 citations

Inherited histocompatibility changes in progeny of irradiated and unirradiated inbred mice

1965 • 133 citations

Heterogeneity and specificity of cloned lines of influenza-virus specific cytotoxic T lymphocytes.

1981 • 132 citations

Simultaneous expression of H-2-restricted and alloreactive recognition by a cloned line of influenza virus-specific cytotoxic T lymphocytes.

1981 • 128 citations

ABSENCE OF SEROLOGICALLY DETECTABLE H-2 ON PRIMITIVE TERATOCARCINOMA CELLS IN CULTURE

1974 • 127 citations

Major Histocompatibility Complex Restricted Cell-Mediated Immunity

1978 • 126 citations

cDNA clones coding for the heavy chain of human HLA-DR antigen.

1982 • 126 citations

New genetic model for allelism at histocompatibility and other complex loci: polymorphism for control of gene expression.

1973 • 126 citations

Heterogeneity in the expression of HLA and tumor-associated antigens by surgically removed and cultured breast carcinoma cells.

1983 • 125 citations

Expression of passively transferred immunity against an established tumor depends on generation of cytolytic T cells in recipient. Inhibition by suppressor T cells.

1983 • 123 citations

The Clonal Selection Hypothesis Evaluated by Grafted Cells Reacting Against their Hosts

1967 • 121 citations

The amino acid sequence and gene organization of the heavy chain of the HLA-DR antigen: homology to immunoglobulins.

1982 • 121 citations

Variation in MHC Antigenic Profiles of Tumor Cells and its Biological Effects

1981 • 120 citations

Comparison of the cloned H-2Kbm1 variant gene with the H-2Kb gene shows a cluster of seven nucleotide differences.

1983 • 120 citations

Cell-mediated immunity and the major histocompatibility complex

1978 • 119 citations

Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator cells crossreact with chemically modified syngeneic cells.

1977 • 118 citations

The Human Immune Response Region (HLA‐D) and Disease Susceptibility

1983 • 117 citations

Helper and suppressor T cell factors

1980 • 117 citations

Immunological Surveillance

1970 • 116 citations

Genetic Control of the Cytotoxic T Cell Response to SV40 Tumor-Associated Specific Antigen

1979 • 116 citations

Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in A(e):E(a), complex expression causes a corresponding defect in antigen-presenting cell function

1982 • 115 citations

A viral polymerase involved in recognition of influenza virus-infected cells by a cytotoxic T-cell clone

1982 • 113 citations

Influenza virus‐specific cytotoxic T cells in man; induction and properties of the cytotoxic cell

1978 • 112 citations

Transfer factor in cellular immunity.

1974 • 111 citations

The Shope Papilloma-Carcinoma Complex of Rabbits: A Model System of Neoplastic Progression and Spontaneous Regression

1981 • 110 citations

The Murine Sarcoma Virus-Induced Tumor: Exception or General Model in Tumor Immunology?

1977 • 108 citations

H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. The H-2K structure involved is coded by a single cistron defined by H-2Kb mutant mice.

1976 • 107 citations

ANTIGENIC SPECIFICITIES ON MURINE SARCOMA CELLS

1971 • 107 citations

T cell factor (interleukin 2) allows in vivo induction of T helper cells against heterologous erythrocytes in athymic (nu/nu) mice

1980 • 107 citations

Structure of crossreactive human histocompatibility antigens HLA-A28 and HLA-A2: possible implications for the generation of HLA polymorphism.

1982 • 106 citations

Hybrid H-2 histocompatibility gene products assign domains recognized by alloreactive T cells.

1983 • 104 citations

Antibodies to Human T-Cell Leukemia Virus Membrane Antigens (HTLV-MA) in Hemophiliacs

1983 • 102 citations

Epitope specificity of the T cell proliferative response to lysozyme: proliferative T cells react predominantly to different determinants from those recognized by B cells

1980 • 101 citations

HLA antigen-related restriction of T lymphocyte cytotoxicity to Epstein-Barr virus.

1980 • 100 citations

Heterogeneity of the cytotoxic response of thymus-derived lymphocytes after immunization with influenza viruses.

1977 • 98 citations

Tumor Progression and Homeostasis

1976 • 98 citations

Antigen-specific. I region-restricted interactions in vitro between tumor cell lines and T cell hybridomas.

1982 • 96 citations

H‐2 Restricted Cytolytic and Noncytolytic T Cell Clones: Isolation, Specificity and Functional Analysis

1981 • 95 citations

Characterization of a progressive tumor from C3H fibroblasts transformed in vitro with SV40 virus. Immunoresistance in vivo correlates with phenotypic loss of H-2Kk.

1982 • 95 citations

Increased synthesis and expression of H-2 antigens on thymocytes as a result of radiation leukemia virus infection: a possible mechanism for H-2 linked control of virus-induced neoplasia.

1978 • 95 citations

Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered-self hypothesis.

1982 • 95 citations

Relationship between T-antigen and tumor-specific transplantation antigen in simian virus 40-transformed cells

1979 • 94 citations

Lysis of human solid tumors by autologous cells sensitized in vitro to alloantigens.

1981 • 94 citations

Influenza virus site recognized by a murine helper T cell specific for H1 strains. Localization to a nine amino acid sequence in the hemagglutinin molecule.

1983 • 93 citations

Generation of cytotoxic T lymphocytes to autologous human leukaemia cells by sensitisation to pooled allogeneic normal cells

1978 • 92 citations

Allospecific and virus-specific cytolytic T lymphocytes are restricted to the N or C1 domain of H-2 antigens expressed on L cells after DNA-mediated gene transfer.

1983 • 92 citations

Evidence for an H–2/viral protein complex on the cell surface as the basis for the H–2 restriction of cytotoxicity

1977 • 91 citations

Early presence of ribonucleoprotein antigen on surface of influenza virus-infected cells

1977 • 91 citations

Immune Deficiency Predisposing to Epstein-Barr Virus-Induced Lymphoproliferative Diseases: The X-Linked Lymphoproliferative Syndrome as a Model

1981 • 91 citations

HLA and Susceptibility to Hodgkin's Disease

1983 • 90 citations

Effects of fourH-2K mutations on virus-induced antigens recognized by cytotoxic T cells

1976 • 89 citations

Induction of a tumor with greatly increased metastatic growth potential by injection of cells from a low‐metastatic H‐2 heterozygous tumor cell line into an H‐2 incompatible parental strain

1978 • 87 citations

Immune response gene function correlates with the expression of an Ia antigen. I. Preferential association of certain Ae and E alpha chains results in a quantitative deficiency in expression of an Ae:E alpha complex.

1982 • 87 citations

Eight new histocompatibility mutations associated with theH-2 complex

1976 • 86 citations

Fine specificity of alloimmune cytotoxic T lymphocytes directed against H-2K. A study with Kb mutants.

1980 • 86 citations

DNA Sequence of the Gene Encoding the E_αIa Polypeptide of the BALB/c Mouse

1982 • 85 citations

Dissection of the B10.D2 anti-H-2Kb cytolytic T lymphocyte receptor repertoire.

1980 • 84 citations

HLA-DR light chain has a polymorphic N-terminal region and a conserved immunoglobulin-like C-terminal region

1982 • 84 citations

The Role of Viruses in Human Tumors

1980 • 84 citations

Specific cytotoxicity against autologous tumour and proliferative responses of human lymphocytes grown in interleukin 2

1982 • 83 citations

The T lymphocyte antigen receptor—paradigm lost

1982 • 82 citations

The suppression of Epstein-Barr virus infection in vitro occurs after infection but before transformation of the cell.

1980 • 82 citations

Specificity of auto‐tumor cytotoxicity exerted by fresh, activated and propagated human t lymphocytes

1982 • 82 citations

Conformational changes at topologically distinct antigenic sites on the influenza A/PR/8/34 virus HA molecule are induced by the binding of monoclonal antibodies

1982 • 82 citations

Recognition by cytotoxic T lymphocytes of cells expressing fragments of the SV40 tumor antigen.

1983 • 81 citations

Specificities of Killing by Cytotoxic Lymphocytes Generated in Vivo and in Vitro to Syngeneic SV40 Transformed Cells

1977 • 81 citations

Cell cycle related heterogeneity of Ia antigen expression on a murine B lymphoma cell line:analysis by flow cytometry.

1981 • 81 citations

Generation of an HLA-restricted cytotoxic T cell line reactive against cultured tumor cells from a patient infected with human T cell leukemia/lymphoma virus.

1983 • 80 citations

Vaccinia-specific cytotoxic T-cell responses in the context of H-2 antigens not encountered in thymus may reflect aberrant recognition of a virus-H-2 complex.

1979 • 80 citations

Proportion of T and B Lymphocytes in Lesions of Marek's Disease: Theoretical Implications for Pathogenesis

1973 • 79 citations

Participation of histocompatibility antigens in capping of molecularly independent cell surface components by their specific antibodies

1978 • 79 citations

Expression of H–2, laminin and SV40T and TASA on differentiation of transformed murine teratocarcinoma cells

1980 • 78 citations

Identification of a new CML target antigen controlled by a gene associated with theQa-2 locus

1978 • 76 citations

The induction of virus-specific cytotoxic T lymphocytes with solubilized viral and membrane proteins.

1978 • 76 citations

Nonrandom inclusion of H-2K and H-2D antigens in Friend virus particles from mice of various strains.

1978 • 76 citations

Studies on the role of the host immune response in recovery from Friend virus leukemia. II. Cell-mediated immunity.

1976 • 76 citations

Absence of H-2 antigens capable of reacting with cytotoxic T cells on a teratoma line expressing a T/t locus antigen.

1975 • 74 citations

Influenza A specific cytotoxic T-cell clones that do not recognize viral glycoproteins

1982 • 74 citations

Lymphocyte specificity to protein antigens. II. Fine specificity of T-cell activation with cytochrome c and derived peptides as antigenic probes.

1979 • 73 citations

The augmentation of in vitro and in vivo tumor-specific T cell-mediated immunity by amplifier T lymphocytes.

1980 • 73 citations

Distribution and mobility of murine histocompatibility H-2Kk antigen in the cytoplasmic membrane.

1983 • 73 citations

Mhc RESTRICTION AND Ir GENES

1982 • 73 citations

Cells that express viral antigens but lack H-2 determinants are not lysed by immune thymus-derived lymphocytes but are lysed by other antiviral immune attack mechanisms.

1976 • 72 citations

Quantitation and clonal isolation of cytolytic T lymphocyte precursors selectively infiltrating murine sarcoma virus-induced tumors.

1981 • 72 citations

Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.

1976 • 71 citations

Experiments and Speculation on Antiviral Specificity of T and B Cells

1981 • 69 citations

Limiting dilution analysis of the specificity of influenza-immune cytotoxic T cells

1982 • 68 citations

Increased susceptibility to virus oncogenesis of congenitally thymus-deprived nude mice

1974 • 67 citations

A role for elevated H-2 antigen expression in resistance to neoplasia caused by radiation-induced leukemia virus. Enhancement of effective tumor surveillance by killer lymphocytes.

1979 • 67 citations

Host factors in human carcinogenesis

1983 • 67 citations

Demonstration of multiple antigenic sites of the SV40 transplantation rejection antigen by using cytotoxic T lymphocyte clones.

1983 • 65 citations

CANCER AND SUBVERSION OF HOST DEFENCES

1981 • 63 citations

Exploitation of monoclonal antibodies: a "who's who" of haemopoietic malignancy.

1981 • 62 citations

Inhibition of killer‐target cell interaction by monoclonal anti‐H‐2 antibodies

1979 • 62 citations

Effect of the H-2 gene complex rates of fibroblast intercellular adhesion

1978 • 62 citations

Changes in Ia-like antigen expression on malignant human cells

1981 • 61 citations

Haplotype-specific suppression of cytotoxic T cell induction by antigen inappropriately presented on T cells.

1983 • 60 citations

Mutant lines of guinea pig L2C leukemia. I. Deletion of Ia alloantigens is associated with a loss in immunogenicity of tumor-associated transplantation antigens.

1976 • 59 citations

The Influence of the Major Histocompatibility Complex on the Function of T‐Helper Cells in Antibody Formation

1978 • 58 citations

Cytotoxic T-memory cells in virus infection and the specificity of helper T cells.

1982 • 58 citations

CHARACTERISTICS OF TRANSPLANTATION IMMUNITY IN THE SPONGE, CALLYSPONGIA DIFFUSA

1980 • 57 citations

Selective turnover and shedding of H-2K and H-2D antigens is controlled by the major histocompatibility complex. Implications for H-2-restricted recognition.

1980 • 57 citations

Genes of the major histocompatibility complex

1982 • 57 citations

Recognition of viral glycoproteins by influenza A-specific cross-reactive cytolytic T lymphocytes.

1980 • 56 citations

Studies on the nature of the cell surface antigen reacting with cytolytic T lymphocytes in murine oncornavirusinduced tumors

1978 • 56 citations

ALLOGENEIC POLYMORPHISM AND ALLOIMMUNE MEMORY IN THE CORAL, MONTIPORA VERRUCOSA

1980 • 56 citations

Characterization of Ia8 Antigen, Thy-1.2 Antigen, Complement Receptors, and Virus Production in a Group of Murine Virus-Induced Leukemia Cell Lines

1976 • 55 citations

Multiple Polymorphism in Relation to Histocompatibility Antigens

1973 • 55 citations

Requirement of thymus-derived theta-positive lymphocytes for rejection of DNA virus (SV 40) tumors in mice.

1974 • 55 citations

Proceedings of the third International Workshop on Nude Mice

1982 • 55 citations

Antigenic specificity of the cytolytic T lymphocyte response to murine sarcoma virus-induced tumors. III. Characterization of cytolytic T lymphocyte clones specific for Moloney leukemia virus-associated cell surface antigens.

1980 • 55 citations

Loss of H-2Kk gene product(s) from an AKR spontaneous leukaemia

1979 • 54 citations

Alterations in Major Histocompatibility Complex Phenotypes of Mouse Cloned T10 Sarcoma Cells: Association With Shifts From Nonmetastatic to Metastatic Cells<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 54 citations

Cytotoxic T lymphocyte recognition of transfected cells expressing a cloned retroviral gene

1983 • 54 citations

T and B cells that recognize the same antigen do not transcribe similar heavy chain variable region gene segments.

1983 • 54 citations

Interactions of vesicular stomatitis virus with murine cell surface antigens

1976 • 52 citations

HLA-A,B,C and DR Alloantigen Expression on Forty-Six Cultured Human Tumor Cell Lines2

1981 • 52 citations

Isolation of a cloned cell line expressing variant H–2Kk using fluorescence-activated cell sorting

1981 • 52 citations

Lysis of syngeneic solid tumor cells by alloantigen stimulated mouse T and non-T cells.

1980 • 52 citations

Monoclonal antibody to SV40 T-antigen blocks lysis of cloned cytotoxic T-cell line specific for SV40 TASA

1983 • 52 citations

Influenza virus-specific cytotoxic T lymphocytes recognize HLA-molecules. Blocking by monoclonal anti-HLA antibodies.

1980 • 51 citations

Specificity of T cell clones for antigen and autologous major histocompatibility complex products determines specificity for foreign major histocompatibility complex products.

1983 • 51 citations

Histocompatibility changes in tumors

1958 • 51 citations

Epstein‐Barr virus specific T‐cell response in nasopharyngeal carcinoma patients

1983 • 50 citations

Viral specificity of H-2-restricted T killer cells directed against syngeneic tumors induced by Gross, Friend, or Rauscher leukemia virus.

1979 • 50 citations

Do NK cells play a role in anti-tumor surveillance?

1980 • 50 citations

The Genetic and Cellular Basis of Regulation of the Immune Response to Tumor Antigens

1980 • 49 citations

Association of Tumor and Histocompatibility Antigens in Sera of Lymphoma-Bearing Mice

1973 • 49 citations

The role of Ia molecules in the activation of T lymphocytes. III. Antigen-specific, Ia-restricted, interleukin 2-producing T cell hybridomas with detectable affinity for the restricting I-A molecule.

1983 • 48 citations

Two independent receptors allow selective target lysis by T cell clones.

1983 • 45 citations

H–2a-associated alloantigen expressed by several transplacentally-induced lung tumours of C3Hf mice

1977 • 45 citations

H-2 effects on cell-cell interactions in the response to single non-H-2 alloantigens. II. H-2 D region control of H-7.1-specific stimulator function in mixed lymphocyte culture and susceptibility to lysis by H-7.1- specific cytotoxic cells

1977 • 45 citations

Loss of Expression of Transplantation Antigens Encoded by the <italic>H-2K</italic> Locus on Lewis Lung Carcinoma Cells and Its Relevance to the Tumor's Metastatic Properties<xref ref-type="fn" rid="FN2">2</xref>

1983 • 45 citations

Inflammatory cells in solid murine neoplasms. IV. Cytolytic T lymphocytes isolated from regressing or progressing Moloney sarcomas.

1977 • 45 citations

Monoclonal antibodies to hemagglutinin and to H‐2 inhibit the cross‐reactive cytotoxic T cell populations induced by influenza

1980 • 41 citations

THE ROLE OF H‐2 I REGION GENES IN REGULATION OF THE IMMUNE RESPONSE *

1981 • 41 citations

Quantitative variations in the expression of H-2 antigens on murine leukemia virus-induced tumor cells can affect the H-2 restriction patterns of tumor-specific cytolytic T lymphocytes.

1981 • 40 citations

Ia antigens and epidermal Langerhans cells.

1980 • 40 citations

Preferential H-2 association in cytotoxic T cell responses to SV40 tumor-associated specific antigens.

1980 • 40 citations

H-2 effects on cell-cell interactions in the response to single non-H-2 alloantigens

1980 • 39 citations

Detection of simian virus 40 surface‐associated large tumor antigen by enzyme‐catalyzed radioiodination

1982 • 39 citations

H–2 gene expression is required for T cell-mediated lysis of virus-infected target cells

1977 • 38 citations

Human Retroviruses and Adult T-Cell Leukemia-Lymphoma

1982 • 38 citations

Interactions of macromolecules on cell membranes and restrictions of T-cell specificity by products of the major histocompatibility complex

1977 • 38 citations

Immunology: The T-lymphocyte antigen receptor — elusive no more

1984 • 37 citations

Association of Mouse Major Histocompatibility and Rauscher Murine Leukaemia Virus Envelope Glycoprotein Antigens on Leukaemia Cells and their Recognition by Syngeneic Virus‐Immune‐Cytotoxic T‐Lymphocytes

1978 • 37 citations

Quantitation of influenza virus antigens on infected target cells and their recognition by cross-reactive cytotoxic T cells.

1980 • 37 citations

IMPAIRED H‐2 EXPRESSION IN B 16 MELANOMA VARIANTS

1983 • 36 citations

Inhibition of Influenza-Immune T Cell Effector Function by Virus-Specific Hybridoma Antibody

1979 • 36 citations

Immunogenetic analysis ofH-2 mutations

1977 • 35 citations

Role of prethymic cells in acquisition of self-tolerance

1979 • 35 citations

Moloney Virus-Induced Cell Surface Antigens and Histocompatibility Antigens Are Located on Distinct Molecules

1979 • 35 citations

Relationship between trinitrophenyl and H-2 antigens on trinitrophenyl-modified spleen cells. II. Correlation between derivatization of H-2 antigens with trinitrophenyl and the ability of trinitrophenyl-modified cells to react functionally to the CML assay.

1977 • 35 citations

H-2-associated specificity of virus-immune cytotoxic T cells fromH-2 mutant and wild-type mice: M523 (H-2K ka ) and M505(H-2K bd ) do, M504 (H-2D da ) and M506(H-2K fa ) do not crossreact with wild-typeH-2K orH-2D

1977 • 34 citations

Ia-like antigens on freshly explanted human melanoma

1981 • 34 citations

Association between H-2 and Vaccinia Virus-Induced Antigens on the Surface of Infected Cells

1979 • 34 citations

Tumor induction by simian virus 40 in mice is controlled by long-term persistence of the viral genome and the immune response of the host

1984 • 34 citations

Specificity of cytolytic T cells directed against AKR/Gross virus-induced syngeneic leukemias: antibodies directed against H-2K, but not against viral proteins, inhibit lysis.

1980 • 34 citations

Physical Association of Histocompatibility Antigens and Tumor-Associated Antigens on the Surface of Murine Lymphoma Cells

1979 • 33 citations

H-2Kb mutations limit the CTL response to SV40 TASA.

1982 • 33 citations

Human T-Cell Leukemia Virus Linked to AIDS

1983 • 33 citations

Spontaneous loss and subsequent stimulation ofH-2 expression in clones of a heterozygous lymphoma cell line

1979 • 32 citations

Antigenic characterization of heterozygous mouse lymphomas after immunoselection in vivo.

1968 • 32 citations

H-2 restriction of adoptive immunotherapy of advanced tumors.

1981 • 32 citations

Cytotoxic T lymphocyte recognition of gp70 on Friend virus-induced erythroleukemia cell clones.

1980 • 31 citations

Self H-2 antigens influence the specificity of alloreactive cells.

1980 • 30 citations

Requirement of Thymus-Derived θ-Positive Lymphocytes for Rejection of DNA Virus (SV40) Tumors in Mice

1974 • 30 citations

Influence of the major histocompatibility complex on the repertoire of allospecific cytolytic T lymphocytes.

1982 • 30 citations

Influence of the Major Histocompatibility Complex on T-Cell Activation

1979 • 30 citations

Abrogation of the in vitro generation of the cytotoxic T‐cell response to a murine tumor: The role of suppressor cells

1982 • 29 citations

Immune-deficiency syndrome (AIDS) A consequence of allogeneic Ia-antigen recognition

1983 • 27 citations

Conformational Changes in Sindbis Virus E1 Glycoprotein Induced by Monoclonal Antibody Binding

1983 • 27 citations

Development and Loss of Virus‐Specific Thymic Competence in Bone Marrow Radiation Chimeras and Normal Mice

1981 • 27 citations

H-2-restricted cytolytic T lymphocytes specific for a subclass of AKR endogenous leukemia virus-induced tumors: correlation of tumor cell susceptibility with expression of the gross cell surface antigen.

1980 • 27 citations

A search for messenger RNA molecules bearing immunoglobulin VH nucleotide sequences in T cells.

1982 • 27 citations

Multiple genes in the H‐2 complex affect differently the number and growth rate of transplacentally induced lung tumours in mice

1983 • 26 citations

Cross-reactions between tumor cells and allogeneic normal tissues. inhibition of a syngeneic lymphoma outgrowth in h-2 and non-h-2 alloimmune balb/c mice

1982 • 26 citations

HLA complex and familial malignant melanoma

1982 • 25 citations

Cytotoxic T cells distinguish between trinitrophenyl- and dinitrophenyl-modified syngeneic cells.

1977 • 25 citations

An immunological basis for inhibition of transformation of human lymphocytes by EB virus

1977 • 25 citations

IMMUNOGENETIC RELATIONSHIPS AMONG GENETICALLY DEFINED, INBRED DOMESTIC SYRIAN HAMSTER STRAINS

1980 • 24 citations

Demonstration of a correlation between tumor cell H-2 antigen content, immunogenicity, and tumorigenicity using lectin-resistant tumor variants.

1981 • 24 citations

T lymphocytes specific for immunoglobulin allotype. II. Cloned Igh-1(b)- specific cytotoxic T cells

1981 • 24 citations

Monoclonal antibody defining a Burkitt's lymphoma-associated antigen detects carbohydrate on neutral glycolipid.

1982 • 23 citations

The Role of the Major Histocompatibility Gene Complex in Murine Cytotoxic T Cell Responses

1980 • 23 citations

H-2 effects on cell-cell interactions in the response to single non-H-2 alloantigens. V. Effects of H-2Kb mutations on presentation of H-4 and H-3 alloantigens.

1982 • 22 citations

Cross-reactivity patterns of vaccinia-specific cytotoxic T lymphocytes from H-2K b mutants

1983 • 22 citations

Epitopes on H-2Dd somatic cell mutants recognized by cytotoxic T cells.

1983 • 21 citations

Identification of a viral antigen recognized by H-2-restricted cytolytic T lymphocytes on a murine leukemia virus-induced tumor.

1983 • 21 citations

Biochemical studies on the H-2K antigens of the MHC mutantsbm3 andbm11

1980 • 21 citations

Biochemical studies of H-2K antigens from a group of related mutants. II. Identification of a shared mutation in B6-H-2 bm6 , B6.C-H-2 bm7 , and B6.C-H-2 bm9

1983 • 21 citations

Specific thymus-derived (T) cell recognition of papova virus-transformed cells.

1982 • 21 citations

Inflammatory Cells in Solid Murine Neoplasms

1977 • 21 citations

Alloreactivity and Tumor Antigens: Generation of Syngeneic Antilymphoma Killer Lymphocytes by Alloimmunization of Mice With Normal Cells<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1983 • 20 citations

Use of somatic cell genetics to study chromosomes contributing to antigen plus I recognition by T cell hybridomas.

1983 • 20 citations

Different D end-dependent antigenic determinants are recognized by H-2-restricted cytotoxic T cells specific for influenza and Bebaru viruses.

1979 • 20 citations

An Examination of MHC Restriction in the Context of a Minimal Clonal Abortion Model for Tolerance

1980 • 19 citations

Cell-surface molecules involved in T-cell functions

1983 • 19 citations

HLA-A,B antigens Ia-like antigens, and tumor-associated antigens on prostate carcinoma cell lines: serologic and immunochemical analysis with monoclonal antibodies.

1981 • 19 citations

A new cytotoxic lymphocyte-defined antigen coded by a gene closely linked to theH-3 locus

1980 • 19 citations

H‐2D CONTROL OF LEUKAEMIA SUSCEPTIBILITY: MECHANISM AND IMPLICATIONS*

1980 • 18 citations

In Vitro Induction of Tumor-Specific Immunity

1977 • 18 citations

Inhibition of cytolytic T lymphocyte clones reactive with Moloney leukemia virus-associated antigens by monoclonal antibodies: a direct approach to the study of H-2 restriction.

1981 • 18 citations

Solubilization of complexes between tumor‐associated and H‐2 antigens from a tumor cell plasma membrane

1980 • 18 citations

Antigen receptors on murine T lymphocytes in contact sensitivity. I. Functional inhibition of effector T cells by monovalent 2,4-dinitrophenol: implication for a two-receptor model.

1981 • 18 citations

Elicitation of anti-viral cytotoxic T lymphocytes with purified viral and H-2 antigens.

1980 • 17 citations

Altered transcription of genes coding for class I histocompatibility antigens in murine tumor cells.

1983 • 17 citations

H-2 antigen variants in a cultured heterozygous mouse leukemia cell line

1980 • 17 citations

Specificity studies on cytolytic T lymphocytes directed against murine leukemia virus-induced tumors. Analysis of monoclonal cytolytic T lymphocytes.

1982 • 17 citations

T cell recognition of antigen in vivo: Role of the H-2 complex

1980 • 17 citations

Fine Specificity and Cytolytic Activity of Continuously Growing Alloreactive Cytotoxic T Lymphocyte Clones

1980 • 17 citations

Tumors induced by murine sarcoma virus contain precursor cells capable of generating tumor-specific cytolytic T lymphocytes.

1979 • 17 citations

Genetically Appropriate Expression of HLA and DR (IA) Alloantigens on Human Melanoma Cell Lines

1980 • 16 citations

H–2 restriction and non-restriction of T-cell-mediated cytotoxicity against mouse mammary tumour targets

1978 • 16 citations

HISTOCOMPATIBILITY DIFFERENCE BETWEEN C3HfeB/HeN AND C3H/HeN MICE: TUMOUR INDUCED IN C3HfeB/HeN MICE EXPRESSES C3H/HeN-ASSOCIATED ALLOANTIGEN

1978 • 16 citations

Review/Commentary The dose-response curve in tumor-immunity

1983 • 16 citations

Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk

1980 • 15 citations

Relationship between Trinitrophenyl and H-2 Antigens on Trinitrophenyl-Modified Spleen Cells

1977 • 15 citations

Studies of allogeneic tumor transplants: induced rejection of advanced tumors by immune alteration of recipients.

1983 • 14 citations

Multiple splenic lymphoid cell subpopulations regulate H-2 antigen expression on teratocarcinoma cells in vivo.

1983 • 14 citations

Role of H-2 antigens in the host response to methylcholanthrene-induced tumors

1982 • 14 citations

Studies of the mechanisms for the induction of in vivo tumor immunity. VII. Development of specific antitumor immunity in progressors and regressors

1983 • 13 citations

The production of Non-H-2 histocompatibility alloantibodies in the mouse

1977 • 13 citations

H-2 Effects on cell-cell interactions in the response to single non-H-2 alloantigens

1983 • 13 citations

Genetic control of the immune response to myoglobins. VI. Distinct Ir genes for different myoglobins: complementing genes in I-A and H-2D for equine myoglobin.

1982 • 13 citations

Biochemical evidence for expression of a semi-allogeneic, H-2 antigen by a murine adenocarcinoma.

1983 • 13 citations

Transformation Induced by Herpes Simplex Virus: A Potentially Novel Type of Virus-Cell Interaction

1981 • 12 citations

MHC restriction, self-tolerance and the thymus

1980 • 12 citations

The question of derepression ofH-2 specificities in virus-infected cells: Failure to detect specific alloreactive T cells after systemic virus infection or alloantigens detectable by alloreactive T cells on virus-infected target cells

1977 • 12 citations

IMMUNOGENETIC STUDIES ON METH‐A‐VACCINIA TUMOUR CELLS IN VIVO AND IN VITRO*

1977 • 11 citations

Effect of interleukin 2 on cytotoxic effectors: I. short‐term culture of the cytotoxic effectors and the in vivo anti‐tumor activity of the cultured effectors isolated from tumor site

1982 • 11 citations

T helper cells in immune mice amplify the primary anti-tumor cytotoxic response.

1982 • 10 citations

Adoption of tumor immunity: role of the major histocompatibility complex.

1981 • 9 citations

The spatial relationship of the viral and H-2 antigens recognized by anti-viral CTLs

1980 • 9 citations

The Localized Primary Cytotoxic T‐cell Response to Cells Expressing Minor Histocompatibility Differences

1984 • 9 citations

Role of accessory cells in the induction of a secondary cytotoxic response to Moloney murine sarcoma virus-induced tumors.

1983 • 9 citations

Serologic and biochemical identification of minor histocompatibility (H-4) antigens.

1981 • 8 citations

Accessory cells in the in vitro generation of type C virus-specific T killer lymphocytes. II. Demonstration of a T helper cell in the spleen of in vivo primed mice.

1981 • 8 citations

H-2 restriction of the T cell response to chemically induced tumors: evidence from F1 replaced by parent chimeras.

1982 • 8 citations

Genetics of the immune response

1984 • 7 citations

Stimulation of secondary anti-MSV cytolytic T lymphocytes with MBL-2 reconstituted membranes.

1983 • 7 citations

Negatively selected H-2bml and H-2b cells stimulated with vaccinia virus completely discriminate between mutant and wild-type H-2K alleles.

1981 • 6 citations

H-2 effects on cell-cell interactions in the response to single non-H-2 alloantigens

1981 • 6 citations

Thymus dependency of neonatal tolerance induction in the absence of detectable suppressor cells

1980 • 6 citations

Induction of virus-specific modifications recognized by cytotoxic T cells is not altered by prior substitution of target cells with trinitrophenol.

1977 • 6 citations

Cytotoxic T Lymphocytes to Murine Plasmacytoma Cells in Allogeneic and Syngeneic Mice: H-2 Antigens Are Essential in the Induction and Effector Stages of Ctl

1978 • 5 citations

Tumor immunity to murine plasma cell tumors. VII. Expression of H-2 and tumor antigens on Ig synthesis variants of MPC-11.

1982 • 4 citations

Likely T Cell Receptor Gene Cloned

1983 • 4 citations

The Induction of Cytolytic T Lymphocytes with Syngeneic Trinitrophenyl-Coupled Membranes

1979 • 4 citations

Cross-reactivity patterns of influenza-specific cytotoxic T lymphocytes from H-2Kb mutant mice.

1983 • 4 citations

A monoclonal antibody to an interspecies major histocompatibility determinant inhibits a virus-specific T-cell clone

1982 • 3 citations

H‐2K RESTRICTION OF THE T CELL‐MEDIATED LYSIS OF A CHEMICALLY‐INDUCED BALB/c FIBROSARCOMA

1983 • 2 citations

Characterization of “H‐2K,D‐like structures” on MM2 × mouse L cell hybrids. II. An “H‐2K^d‐like” structure on C3H‐derived tumor

1983 • 2 citations

Role of H-2 antigens in the host response against transplanted methylcholanthrene-induced tumors

1983 • 2 citations

Apparent alteration in MHC antigens in K36.16, an AKR thymoma, does not result in genetic rearrangement.

1983 • 1 citations