Causation of Crohn’s Disease byMycobacterium aviumSubspeciesParatuberculosis

Bacterial Biofilms: A Common Cause of Persistent Infections

1999 • 11,429 citations

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

1998 • 7,572 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

A Molecular View of Microbial Diversity and the Biosphere

1997 • 2,747 citations

Impact of Culture-Independent Studies on the Emerging Phylogenetic View of Bacterial Diversity

1998 • 2,361 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Comparative Genomics of BCG Vaccines by Whole-Genome DNA Microarray

1999 • 1,537 citations

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

1998 • 1,451 citations

Adaptive radiation in a heterogeneous environment

1998 • 1,288 citations

Global Climate and Infectious Disease: The Cholera Paradigm

1996 • 1,262 citations

Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution

1997 • 1,123 citations

Epidemiology of infection by nontuberculous mycobacteria

1996 • 1,083 citations

Pasteurized Milk as a Vehicle of Infection in an Outbreak of Listeriosis

1985 • 1,082 citations

Evolution of high mutation rates in experimental populations of E. coli

1997 • 909 citations

Ruminant paratuberculosis (Johne's disease): the current status and future prospects.

1984 • 845 citations

High Mutation Frequencies Among Escherichia coli and Salmonella Pathogens

1996 • 836 citations

Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin

1995 • 672 citations

Epidemiology of Crohn's Disease and Ulcerative Colitis in a Central Canadian Province: A Population-based Study

1999 • 665 citations

Crohn's disease in Olmsted County, Minnesota, 1940–1993: Incidence, prevalence, and survival

1998 • 632 citations

Mycolactone: A Polyketide Toxin from Mycobacterium ulcerans Required for Virulence

1999 • 628 citations

Antimicrobial agent resistance in mycobacteria: molecular genetic insights

1995 • 601 citations

Comparison of Methods Based on Different Molecular Epidemiological Markers for Typing of Mycobacterium tuberculosis Complex Strains: Interlaboratory Study of Discriminatory Power and Reproducibility

1999 • 576 citations

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

1998 • 542 citations

Forging a Link Between Biofilms and Disease

1999 • 542 citations

Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays

1999 • 540 citations

The molecular ecology of legionellae

1996 • 539 citations

Analysis ofEscherichia coliO157:H7 Survival in Ovine or Bovine Manure and Manure Slurry

1998 • 517 citations

The pathology and pathogenesis of paratuberculosis in ruminants and other species

1997 • 499 citations

Therapy of tuberculosis in mice by DNA vaccination

1999 • 488 citations

Sequence and characteristics or IS900, an insertion element identified in a human Crohn's disease isolate orMycobacterium paratuberculosis

1989 • 479 citations

Mechanisms of latency in Mycobacterium tuberculosis

1998 • 476 citations

High Rates of Conjugation in Bacterial Biofilms as Determined by Quantitative In Situ Analysis

1999 • 469 citations

Interaction of Mycobacterium avium with environmental amoebae enhances virulence

1997 • 442 citations

Sensitivity and specificity of PCR for detection of Mycobacterium tuberculosis: a blind comparison study among seven laboratories

1994 • 436 citations

Persistent colonisation of potable water as a source of Mycobacterium avium infection in AIDS

1994 • 416 citations

Trojan Horses of the microbial world: protozoa and the survival of bacterial pathogens in the environment

1994 • 415 citations

Manure and Microbes: Public and Animal Health Problem?

1997 • 406 citations

Preclinical and Clinical Manifestations of Paratuberculosis (Including Pathology)

1996 • 405 citations

Bioactive IL-18 Expression Is Up-Regulated in Crohn’s Disease

1999 • 399 citations

Numerical Taxonomy of Mycobactin-Dependent Mycobacteria, Emended Description of Mycobacterium avium, and Description of Mycobacterium avium subsp. avium subsp. nov., Mycobacterium avium subsp. paratuberculosis subsp. nov., and Mycobacterium avium subsp. silvaticum subsp. nov.

1990 • 393 citations

Gastrointestinal Illness and the Biopsychosocial Model

1998 • 388 citations

Mycobacterium paratuberculosis DNA in Crohn's disease tissue.

1992 • 379 citations

Mycobacterium paratuberculosis cultured from milk and supramammary lymph nodes of infected asymptomatic cows

1992 • 374 citations

Occurrence of Nontuberculous Mycobacteria in Environmental Samples

1999 • 370 citations

Resuscitation of viable but nonculturable Legionella pneumophila Philadelphia JR32 by Acanthamoeba castellanii

1997 • 366 citations

Growth of Legionella pneumophila in Acanthamoeba castellanii enhances invasion

1994 • 366 citations

Inflammatory bowel disease and domestic hygiene in infancy

1994 • 358 citations

Survival of coliforms and bacterial pathogens within protozoa during chlorination

1988 • 356 citations

Crohn's disease and the mycobacterioses: a review and comparison of two disease entities

1989 • 354 citations

Mycobacterial lipoarabinomannan: An extraordinary lipoheteroglycan with profound physiological effects

1998 • 350 citations

Chlorine, Chloramine, Chlorine Dioxide, and Ozone Susceptibility of Mycobacterium avium

2000 • 325 citations

Isolation of Mycobacterium paratuberculosis from colostrum and milk of subclinically infected cows.

1995 • 315 citations

Chaos, Persistence, and Evolution of Strain Structure in Antigenically Diverse Infectious Agents

1998 • 298 citations

Characteristics of an unclassified Mycobacterium species isolated from patients with Crohn's disease

1984 • 296 citations

IS900 PCR to detect Mycobacterium paratuberculosis in retail supplies of whole pasteurized cows' milk in England and Wales

1996 • 292 citations

Identification of two groups of Mycobacterium paratuberculosis strains by restriction endonuclease analysis and DNA hybridization

1990 • 275 citations

Impact of Culture-Independent Studies on the Emerging Phylogenetic View of Bacterial Diversity

1998 • 274 citations

Mycobacterium aviumBacilli Grow Saprozoically in Coculture withAcanthamoeba polyphagaand Survive within Cyst Walls

1998 • 271 citations

Mycobacteria in water

1984 • 269 citations

Clustering of increased small intestinal permeability in families with Crohn's disease

1997 • 264 citations

Viable but non-culturable Vibrio cholerae O1 revert to a cultivable state in the human intestine

1996 • 258 citations

Johne's Disease: A Hidden Threat

1998 • 257 citations

Mechanism for the Water-to-Air Transfer and Concentration of Bacteria

1970 • 249 citations

Description and classification of different types of lesion associated with natural paratuberculosis infection in sheep

1996 • 247 citations

Invasion of Protozoa by Legionella pneumophila and Its Role in Bacterial Ecology and Pathogenesis

1998 • 245 citations

Unexplored reservoirs of pathogenic bacteria: protozoa and biofilms

1999 • 243 citations

Growth characteristics of atypical mycobacteria in water and their comparative resistance to disinfectants

1978 • 242 citations

Mycobacterium avium Complex Infection

1988 • 241 citations

Role of α-Dystroglycan as a Schwann Cell Receptor for Mycobacterium leprae

1998 • 233 citations

Isolation of Mycobacterium paratuberculosis from colostrum and milk of subclinically infected cows

1995 • 230 citations

Possible role of Mycobacteria in inflammatory bowel disease

1984 • 228 citations

T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection.

1997 • 228 citations

Pathoadaptive mutations: gene loss and variation in bacterial pathogens

1999 • 217 citations

Inactivation of Mycobacterium paratuberculosis in cows' milk at pasteurization temperatures

1996 • 216 citations

Evaluation of Modified BACTEC 12B Radiometric Medium and Solid Media for Culture ofMycobacterium aviumsubsp.paratuberculosisfrom Sheep

1999 • 211 citations

Interaction of Legionella pneumophila with Acanthamoeba castellanii: uptake by coiling phagocytosis and inhibition of phagosome-lysosome fusion

1996 • 205 citations

A Macrophage Invasion Mechanism of Pathogenic Mycobacteria

1997 • 204 citations

Different intestinal permeability patterns in relatives and spouses of patients with Crohn’s disease: an inherited defect in mucosal defence?

1999 • 203 citations

Physiological Characterization of Viable-but-Nonculturable Campylobacter jejuni Cells

1999 • 197 citations

Thermal Tolerance of Mycobacterium paratuberculosis

1998 • 197 citations

Pathological Evaluation of Paratuberculosis in Naturally Infected Cattle

1978 • 196 citations

Polymerase chain reaction detection of Mycobacterium paratuberculosis and Mycobacterium avium subsp silvaticum in long term cultures from Crohn's disease and control tissues.

1992 • 196 citations

Epithelial permeability to proteins in the noninflamed ileum of Crohn's disease?

1999 • 195 citations

On the etiology of Crohn disease.

1996 • 194 citations

Epidemiological Study of Paratuberculosis in Wild Rabbits in Scotland

1999 • 194 citations

Serotype conversion in Vibrio cholerae O1.

1992 • 190 citations

Intracellular accumulation of azithromycin by cultured human fibroblasts

1990 • 189 citations

Microbiological safety of drinking water: United States and global perspectives.

1999 • 188 citations

Occurrence of mycobacteria in biofilm samples

1992 • 187 citations

Appendicectomy, childhood hygiene, Helicobacter pylori status, and risk of inflammatory bowel disease: a case control study

1998 • 183 citations

Epidemiology of infection by nontuberculous mycobacteria. IV. Preferential aerosolization of Mycobacterium intracellulare from natural waters.

1983 • 181 citations

Mycobacterium paratuberculosis isolated from fetuses of infected cows not manifesting signs of the disease

1992 • 176 citations

Standardisation of restriction fragment length polymorphism analysis for Mycobacterium avium subspecies paratuberculosis

1999 • 171 citations

Down-Regulation of CD1 on Antigen-Presenting Cells by Infection withMycobacterium tuberculosis

1998 • 169 citations

Two-year-outcomes analysis of Crohn's disease treated with rifabutin and macrolide antibiotics

1997 • 168 citations

The Thermal Resistance of Mycobacterium Paratuberculosis in Raw Milk under Conditions Simulating Pasteurization

1993 • 166 citations

PCR in laboratory diagnosis of human Borrelia burgdorferi infections

1997 • 165 citations

Comparison of Free-Living Amoebae in Hot Water Systems of Hospitals with Isolates from Moist Sanitary Areas by Identifying Genera and Determining Temperature Tolerance

1998 • 162 citations

IS901, a new member of a widespread class of atypical insertion sequences, is associated with pathogenicity in Mycobacterium avium

1991 • 162 citations

Ingested Listeria monocytogenes survive and multiply in protozoa

1990 • 159 citations

Rapid Detection of Mycobacterium paratuberculosis in Clinical Samples from Ruminants and in Spiked Environmental Samples by Modified BACTEC 12B Radiometric Culture and Direct Confirmation by IS 900 PCR

1998 • 158 citations

The pathology of ovine paratuberculosis: Gross and histological changes in the intestine and other tissues

1996 • 158 citations

IL-6 produced by macrophages infected with Mycobacterium species suppresses T cell responses.

1997 • 158 citations

Intraphagocytic growth induces an antibiotic-resistant phenotype of Legionella pneumophila

1995 • 157 citations

PCR-restriction endonuclease analysis for identification and strain typing ofMycobacterium aviumsubsp.paratuberculosisandMycobacterium aviumsubsp.aviumbased on polymorphisms in IS1311

1999 • 156 citations

Latent pulmonary involvement in Crohn's disease: biological, functional, bronchoalveolar lavage and scintigraphic studies.

1986 • 154 citations

Isolation of Mycobacterium paratuberculosis from the milk of a cow with Johne's disease.

1981 • 153 citations

Mycobacterium paratuberculosis Infection in a Colony of Stumptail Macaques (Macaca arctoides)

1987 • 147 citations

Use of short-term culture for identification of Mycobacterium avium subsp. paratuberculosis in tissue from Crohn's disease patients

2000 • 144 citations

Isolation of Mycobacterium paratuberculosis from Milk by Immunomagnetic Separation

1998 • 139 citations

Herd prevalence and geographic distribution of, and risk factors for, bovine paratuberculosis in Wisconsin.

1994 • 137 citations

Characterization of IS900 loci in Mycobacterium avium subsp. paratuberculosis and development of multiplex PCR typing The GenBank accession numbers for the sequences reported in this paper are AJ011838, AJ250015–AJ250023 and AJ251434–AJ251437.

2000 • 136 citations

Interleukin 4 in inflammatory bowel disease and mucosal immune reactivity

1996 • 136 citations

Extracellular and intracellular activities of clarithromycin used alone and in association with ethambutol and rifampin against Mycobacterium avium complex

1991 • 133 citations

Detection of Mycobacterium paratuberculosis by Polymerase Chain Reaction in Children with Crohn's Disease

1994 • 133 citations

Rifabutin

1994 • 132 citations

Inimical processes: Bacterial self-destruction and sub-lethal injury

1997 • 129 citations

Major histocompatibility class II expression on the small intestinal nervous system in Crohn's disease

1992 • 127 citations

Molecular characterization of the oafA locus responsible for acetylation of Salmonella typhimurium O-antigen: oafA is a member of a family of integral membrane trans-acylases

1996 • 123 citations

Specific detection of Mycobacterium paratuberculosis DNA associated with granulomatous tissue in Crohn's disease.

1994 • 122 citations

Fluoroquinolone Action against Mycobacteria: Effects of C-8 Substituents on Growth, Survival, and Resistance

1998 • 118 citations

Heat inactivation of Mycobacterium paratuberculosis in raw milk: are current pasteurization conditions effective?

1997 • 116 citations

Antimycobacterial therapy in Crohn's disease: results of a controlled, double-blind trial with a multiple antibiotic regimen.

1994 • 116 citations

Rifabutin (Ansamycin LM 427): A New Rifamycin-S Derivative for the Treatment of Mycobacterial Diseases

1987 • 114 citations

Molecular Mechanisms of Clarithromycin Resistance in Mycobacterium avium: Observation of Multiple 238 rDNA Mutations in a Clonal Population

1996 • 111 citations

Disease Due to Mycobacterium avium-intracellulare

1985 • 110 citations

Impaired response of activated mononuclear phagocytes to interleukin 4 in inflammatory bowel disease

1995 • 109 citations

Clonal descent and microevolution of Neisseria meningitidis during 30 years of epidemic spread

1997 • 107 citations

Phagocytosis in Acanthamoeba: I. A mannose receptor is responsible for the binding and phagocytosis of yeast

1990 • 106 citations

Herd prevalence and geographic distribution of, and risk factors for, bovine paratuberculosis in Wisconsin

1994 • 106 citations

Application of a polymerase chain reaction for the detection of Mycobacterium leprae in skin tissues

1991 • 105 citations

Paratuberculosis in Small Ruminants, Deer, and South American Camelids

1996 • 105 citations

Molecular Phylogeny of the Mycobacterium avium Complex Demonstrates Clinically Meaningful Divisions

1994 • 105 citations

The evolution of epidemic Vibrio cholerae strains

1997 • 104 citations

Mycobacterium paratuberculosis in Intestinal Tissue from Patients with Crohn's Disease Demonstrated by a Nested Primer Polymerase Chain Reaction

1994 • 104 citations

The oac gene encoding a lipopolysaccharide O-antigen acetylase maps adjacent to the integrase-encoding gene on the genome of Shigella flexneri bacteriophage Sf6

1991 • 103 citations

Evasion of pathogens by avoiding recognition or eradication by complement, in part via molecular mimicry

1999 • 103 citations

Mycobacterium paratuberculosis DNA not detected in Crohn's disease tissue by fluorescent polymerase chain reaction.

1995 • 102 citations

The pathology of Johne's disease in sheep

1990 • 101 citations

Influence of intra-amoebic and other growth conditions on the surface properties of Legionella pneumophila

1993 • 101 citations

Isolation of Mycobacterium paratuberculosis after oral inoculation in uninfected cattle.

1992 • 99 citations

Identification of spheroplast-like agents isolated from tissues of patients with Crohn's disease and control tissues by polymerase chain reaction

1993 • 99 citations

Effect of high-temperature, short-time (HTST) pasteurization on milk containing low numbers of Mycobacterium paratuberculosis

1998 • 98 citations

Survival of Mycobacterium paratuberculosis in slurry.

1977 • 96 citations

Phylogenetic analysis and identification of different serovars of Mycobacterium intracellulare at the molecular level

1990 • 96 citations

Use of restriction fragment length polymorphism as a genetic marker for typing Mycobacterium avium strains

1995 • 96 citations

Survival of Mycobacterium paratuberculosis and preservation of immunoglobulin G in bovine colostrum under experimental conditions simulating pasteurization

1996 • 94 citations

Preliminary report on isolation of mycobacteria from patients with Crohn's disease

1989 • 94 citations

Drug sensitivity and environmental adaptation of myocobacterial cell wall components

1996 • 94 citations

Cryptosporidiosis in Bovine and Human Health

1998 • 94 citations

Effect of higher pasteurization temperatures, and longer holding times at 72°C, on the inactivation ofMycobacterium paratuberculosisin milk

1999 • 93 citations

Prevalence of paratuberculosis (Johne's disease) in the Belgian cattle population

2000 • 92 citations

A method for isolating and cultivating the mycobacterium enteritidis chronicæ pseudotuberculosæ bovis, Jöhne, and some experiments on the preparation of a diagnostic vaccine for pseudo-tuberculous enteritis of bovines

1912 • 91 citations

Controlled trial of rifampicin and ethambutol in Crohn's disease.

1984 • 90 citations

Transcriptional regulation of the macrophage‐induced gene (gspA) of Legionella pneumophila and phenotypic characterization of a null mutant

1997 • 90 citations

Impact of culture-independent studies on the emerging phylogenetic view of bacterial diversity (vol 180, pg 4765, 1998)

1998 • 90 citations

Grand Round: Mycobacterium paratuberculosis cervical lymphadenitis, followed five years later by terminal ileitis similar to Crohn's disease

1998 • 89 citations

Identification of a gene unique toMycobacterium aviumsubspeciesparatuberculosisand application to diagnosis of paratuberculosis

1998 • 88 citations

Effects of several factors on the heat-shock-induced thermotolerance of Listeria monocytogenes

1997 • 88 citations

To be a mutator, or how pathogenic and commensal bacteria can evolve rapidly

1997 • 88 citations

Mucosa‐associated lymphoid tissues as sites for uptake, carriage and excretion of tubercle bacilli and other pathogenic mycobacteria

1999 • 87 citations

Mycobacterium paratuberculosis: A Potential Food-Borne Pathogen?

1997 • 87 citations

Comparison of Large Restriction Fragments of Mycobacterium avium Isolates Recovered from AIDS and Non-AIDS Patients with Those of Isolates from Potable Water

1999 • 86 citations

Controlled trial of antimycobacterial therapy in Crohn's disease

1991 • 86 citations

Prevalence of Mycobacterium paratuberculosis in ileocecal lymph nodes of cattle culled in the United States.

1987 • 85 citations

Controlled trial of anti-tuberculous chemotherapy for two years in Crohn's disease.

1994 • 85 citations

On the mechanism of action of quinolone drugs

1993 • 85 citations

Controlled trial of antituberculous chemotherapy in Crohn's disease: a five year follow up study

1998 • 84 citations

Endosymbioses: cyclical and permanent in evolution

1998 • 83 citations

IS902, an insertion element of the chronic-enteritis-causing Mycobacterium avium subsp. silvaticum

1992 • 82 citations

Rough morphological variants of Mycobacterium avium. Characterization of genomic deletions resulting in the loss of glycopeptidolipid expression

1993 • 81 citations

Isolation and expression of a gene cluster responsible for biosynthesis of the glycopeptidolipid antigens of Mycobacterium avium

1991 • 81 citations

Thermal Inactivation of Mycobacterium paratuberculosis in Milk

1998 • 81 citations

Isolation of mycobacteria from healthy persons' stools.

1988 • 80 citations

Examining a paradox in the pathogenesis of human pulmonary tuberculosis: Immune activation and suppression/anergy

1997 • 79 citations

Cost-benefit analysis of vaccination against paratuberculosis in dairy cattle.

1996 • 78 citations

Relation between serologic response and pathologic findings in sheep with naturally acquired paratuberculosis

1997 • 77 citations

Distribution and environmental risk factors for paratuberculosis in dairy cattle herds in Michigan

1999 • 77 citations

In Vitro and In Vivo Activity of Azithromycin (CP 62,993) Against the Mycobacterium avium Complex

1989 • 77 citations

Identification of restriction fragment length polymorphisms in DNA from Mycobacterium paratuberculosis

1990 • 76 citations

Control of paratuberculosis (Johne's disease) in goats by vaccination

1985 • 76 citations

Sarcoid-like Lymphocytosis of the Lower Respiratory Tract in Patients with Active Crohn's Disease

1986 • 71 citations

The effect of vaccination on the prevalence of paratuberculosis in large dairy herds

1994 • 70 citations

Effects of Above-Optimum Growth Temperature and Cell Morphology on Thermotolerance of Listeria monocytogenes Cells Suspended in Bovine Milk

1998 • 70 citations

Prevalence of enteropathogenic bacteria in surgically treated chronic inflammatory bowel disease.

1998 • 69 citations

Antibodies to Mycobacterium paratuberculosis and nine species of environmental mycobacteria in Crohn's disease and control subjects.

1993 • 69 citations

Vaccination Against Johne’s Disease in Cattle Exposed to Experimental Infection

1965 • 68 citations

Antibodies to Mycobacterium paratuberculosis-specific protein antigens in Crohn's disease

1992 • 67 citations

Detection of Borrelia burgdorferi DNA by polymerase chain reaction in the urine and breast milk of patients with Lyme borreliosis

1995 • 67 citations

A single point mutation in the embB gene is responsible for resistance to ethambutol in Mycobacterium smegmatis

1997 • 66 citations

Mycobacterium paratuberculosis in the semen and genital organs of a semen-donor bull.

1981 • 65 citations

Crohn's disease of the lung.

1990 • 65 citations

The Role of IL-10 in Inflammatory Bowel Disease: "Of Mice and Men"

1999 • 65 citations

Mycobacterial aetiology of Crohn's disease: serologic study using common mycobacterial antigens and a species-specific glycolipid antigen from Mycobacterium paratuberculosis.

1986 • 64 citations

Mycobacteria in the intestine of Japanese patients with inflammatory bowel disease.

1995 • 63 citations

Crohn's disease with respiratory tract involvement.

1987 • 63 citations

Characterization of Mycobacterium paratuberculosis p36 Antigen and Its Seroreactivities in Crohn's Disease

1999 • 63 citations

Mycobacterium paratuberculosis and Crohn's disease.

1991 • 63 citations

Mycobacterium paratuberculosis in reproductive organs and semen of bulls.

1970 • 63 citations

No Mycobacterium paratuberculosis detected in intestinal tissue, including Peyer's patches and lymph follicles, of Crohn's disease

1998 • 59 citations

Serum antibodies to Mycobacterium paratuberculosis in patients with Crohn's disease.

1999 • 59 citations

Use of four DNA insertion sequences to characterize strains of theMycobacterium aviumcomplex isolated from animals

1997 • 58 citations

Characterization of IS 1110, a highly mobiie genetic element from Mycobacterium avium

1994 • 57 citations

Absence of Mycobacterium paratuberculosis DNA in intestinal tissues from Crohn's disease by nested polymerase chain reaction

1999 • 57 citations

Carbohydrate binding proteins involved in phagocytosis by Acanthamoeba

1975 • 57 citations

Antimicrobial agent resistance in mycobacteria: molecular genetic insights.

1995 • 57 citations

Resistance to drugs targeting protein synthesis in mycobacteria

1994 • 56 citations

An abattoir-based study of the prevalence of subclinical Johne's disease in adult cattle in south west England

1996 • 55 citations

Nucleotide sequence ofIS110, an insertion sequence ofStreptomyces coelicolorA3(2)

1987 • 54 citations

PCR Assay for Diagnosis of Human Brucellosis

1999 • 54 citations

Activity of clarithromycin compared with those of other drugs against Mycobacterium paratuberculosis and further enhancement of its extracellular and intracellular activities by ethambutol

1992 • 54 citations

Deoxyribonucleic Acid Relatedness of Mycobacterium paratuberculosis to Other Members of the Family Mycobacteriaceae

1988 • 53 citations

Mechanisms of persistence of mycobacteria

1994 • 53 citations

Simian Immunodeficiency Virus-Inoculated Macaques Acquire Mycobacterium avium from Potable Water during AIDS

1997 • 53 citations

The prevalence of paratuberculosis in culled New England cattle.

1986 • 52 citations

Identification and Recombinant Expression of a Mycobacterium avium Rhamnosyltransferase Gene ( rtfA ) Involved in Glycopeptidolipid Biosynthesis

1998 • 52 citations

Analysis of paraffin sections of Crohn's disease for Mycobacterium paratuberculosis using polymerase chain reaction.

1996 • 52 citations

Isolation of Mycobacteria from Raw Milk^1,2,3

1965 • 52 citations

NoMycobacterium paratuberculosis found in crohn's disease using the polymerase chain reaction

1996 • 52 citations

Comparative in vitro and in vivo activity of rifabutin and rifampicin against mycobacterium avium complex

1988 • 52 citations

Serum antibodies to mycobacterial antigens in active Crohn's disease

1988 • 52 citations

Diagnosis and control of bovine paratuberculosis (Johne's disease).

1983 • 50 citations

Detection of Mycobacterium avium subsp. paratuberculosis in ovine tissues and blood by the polymerase chain reaction

1997 • 49 citations

Psychoimmunology before its time

1984 • 49 citations

Mycobacterium avium-Mycobacterium intracellular complex-induced suppression of T-cell proliferation in vitro by regulation of monocyte accessory cell activity

1990 • 48 citations

Mycobacterium paratuberculosis and Mycobacterium avium subsp. silvaticum DNA cannot be detected by PCR in Crohn's disease tissue.

1998 • 48 citations

An epidemiological study of paratuberculosis in dairy cattle in Ontario: study design and prevalence estimates.

1991 • 47 citations

Role of Mycobacterium paratuberculosis in Crohn's disease

1998 • 47 citations

Agglutinins to bacteria in Crohn's disease.

1980 • 46 citations

Presence of eubacteria in biopsies from Crohn's disease inflammatory lesions as determined by 16S rRNA gene-based PCR.

1999 • 46 citations

Crohn's disease monocytes are primed for accentuated release of toxic oxygen metabolites

1993 • 45 citations

Superoxide generation during phagocytosis by Acanthamoeba castellanii: similarities to the respiratory burst of immune phagocytes

1991 • 45 citations

Characterization of a specific Mycobacterium paratuberculosis recombinant clone expressing 35,000-molecular-weight antigen and reactivity with sera from animals with clinical and subclinical Johne's disease

1997 • 45 citations

Bronchial eosinophilic infiltration in Crohn's disease in the absence of pulmonary disease

1999 • 45 citations

Infections associated with milk and dairy products in Europe and North America, 1980-85.

1987 • 44 citations

The pathogenicity of Mycobacterium avium and related mycobacteria for experimental animals

1983 • 44 citations

Selection of resistant mutants of Mycobacterium avium in beige mice by clarithromycin monotherapy

1992 • 43 citations

Development of a transposon mutagenesis system forMycobacterium aviumsubsp.paratuberculosis

1999 • 43 citations

Discovery of an insertion sequence, IS116, from Streptomyces clavuligerus and its relatedness to other transposable elements from actinomycetes

1990 • 43 citations

Protection againstMycobacterium aviumby DNA Vaccines Expressing Mycobacterial Antigens as Fusion Proteins with Green Fluorescent Protein

1999 • 43 citations

Mucosal cell-mediated immunity to mycobacterial, enterobacterial and other microbial antigens in inflammatory bowel disease

1992 • 42 citations

Quadruple antimycobacterial chemotherapy in Crohn's disease: results at 9 months of a pilot study in 20 patients

1989 • 42 citations

Thermal inactivation of several Mycobacterium spp. in milk by pasteurization

1996 • 42 citations

Isolation of Mycobacterium paratuberculosis from mononuclear cells in tissues, blood, and mammary glands of cows with advanced paratuberculosis

1993 • 41 citations

A Multiplex Polymerase Chain Reaction Assay for the Detection of Mycobacterium paratuberculosis DNA in Crohn's Disease Tissue

1997 • 41 citations

Rifabutin and Ethambutol Do Not Help Recurrent Crohnʼs Disease in the Neoterminal Ileum

1992 • 41 citations

A low G+C content genetic island in Mycobacterium avium subsp. paratuberculosis and M. avium subsp. silvaticum with homologous genes in Mycobacterium tuberculosis

1998 • 41 citations

Evolutionary bottlenecks in the agents of tuberculosis, leprosy, and paratuberculosis

1999 • 40 citations

Johne’s Disease: A Retrospective Study of Vaccinated Herds in Great Britain

1982 • 39 citations

Uterine infection in bovine paratuberculosis.

1967 • 38 citations

IMPROVEMENTS IN THE TECHNIQUES FOR PRIMARY CULTIVATION OF MYCOBACTERIUM PARATUBERCULOSIS.

1964 • 38 citations

Isolation of Johne’s Bacilli from the Udders of Clinically Affected Cows

1954 • 37 citations

Detection of Mycobacterium paratuberculosis in stool samples of patients with inflammatory bowel disease by IS900-based PCR and colorimetric detection of amplified DNA

1998 • 37 citations

Identification and characterization ofMycobacterium paratuberculosis recombinant proteins expressed inE. coli

1994 • 36 citations

Activities of Clarithromycin, Azithromycin, and Ofioxacin in Combination with Liposomal or Unencapsulated Granulocyte-Macrophage Colony-Stimulating Factor against Intramacrophage Mycobacterium avium-Mycobacterium intracellulare

1995 • 35 citations

Susceptibility of horses to Mycobacterium paratuberculosis.

1972 • 35 citations

A killed vaccine against paratuberculosis (Johne's disease) in sheep.

1960 • 35 citations

Investigations on etiology of Crohn's disease

1991 • 35 citations

p43, the protein product of the atypical insertion sequence IS900, is expressed in Mycobacterium paratuberculosis

1992 • 34 citations

Isolation and sequencing of the gene coding for an antigenic 34-kilodalton protein of Mycobacterium paratuberculosis

1993 • 34 citations

Mycobacterium paratuberculosis and inflammatory bowel disease: frequency distribution in serial colonoscopic biopsies using the polymerase chain reaction.

1995 • 34 citations

Terminal or regional ileitis in in swine

1951 • 33 citations

Structure and relevance of the oligosaccharide hapten of Mycobacterium avium serotype 2

1986 • 33 citations

Challenging food microbiology from a molecular perspective

1997 • 33 citations

Crohn's disease and mycobacteria: two cases of Crohn's disease with high anti-mycobacterial antibody levels cured by dapsone therapy

1989 • 31 citations

Factors associated with seroprevalence to Mycobacterium paratuberculosis in small-ruminant farms in the Madrid region (Spain)

1998 • 30 citations

Isolation of atypical mycobacteria from pasteurized milk.

1968 • 30 citations

Loci of Mycobacterium avium ser2 gene cluster and their functions

1994 • 29 citations

Amplification of 16S rRNA sequences to detect Mycobacterium paratuberculosis

1992 • 29 citations

Isolation of Mycobacterium avium subsp paratuberculosis from breast milk of Crohn's disease patients

2000 • 29 citations

Comparative study of Mycobacterium paratuberculosis strains isolated from Crohn's disease and Johne's disease using restriction fragment length polymorphism and arbitrarily primed polymerase chain reaction

1997 • 29 citations

Occurrence, in Crohn's disease, of antibodies directed against a species-specific recombinant polypeptide of Mycobacterium paratuberculosis

1994 • 28 citations

Canine Colitis Comparable to Regional Enteritis and Mucosal Colitis of Man

1972 • 28 citations

An economic and epidemiologic simulation of different control strategies for ovine paratuberculosis

1993 • 28 citations

Treatment of Clinical Paratuberculosis in Cattle

1996 • 28 citations

Acquired resistance in Mycobacterium avium complex strains isolated from AIDS patients and beige mice daring treatment with clarithromycin

1995 • 27 citations

Dapsone in crohn's disease

1975 • 27 citations

Host defense against nontuberculous mycobacterial infections.

1996 • 26 citations

Antibodies toMycobacterium paratuberculosis in patients with Crohn's disease

1991 • 26 citations

Exploring a novel perspective on pathogenic relationships

1999 • 26 citations

Control of Johne's disease in a flock of sheep by vaccination

1993 • 25 citations

T-cellular immune reactions (in macrophage inhibition factor assay) against Mycobacterium paratuberculosis, Mycobacterium kansasii, Mycobacterium tuberculosis, Mycobacterium avium in patients with chronic inflammatory bowel disease.

1990 • 25 citations

IS900 targets translation initiation signals in Mycobacterium avium subsp. paratuberculosis to facilitate expression of its hed gene

1997 • 25 citations

Emergence of Mycobacterium avium Populations Resistant to Macrolides during Experimental Chemotherapy

1998 • 24 citations

Peripheral cell-mediated immune response to mycobacterial antigens in inflammatory bowel disease

1995 • 23 citations

Disease due to Mycobacterium avium-intracellulare

1985 • 23 citations

Identification and control of paratuberculosis in a large goat herd.

1988 • 23 citations

The pathological study of paratuberculosis in goats, centered around the formation of remote lesions.

1968 • 22 citations

A mathematical analysis of microbial inactivation at linearly rising temperatures: calculation of the temperature rise needed to kill Listeria monocytogenes in different foods and methods for dynamic measurements of D and z values

1994 • 21 citations

Experimental Mycobacterium paratuberculosis infection in chickens.

1972 • 21 citations

Antimicrobial activity of rifabutin in combination with two and three other antimicrobial agentsagainst strains of Mycobacterium paratuberculosis

1991 • 20 citations

Differentiation of Australian isolates of Mycobacterium paratuberculosis using pulsed‐field gel electrophoresis

1997 • 20 citations

The examination of milk for the presence of Mycobacterium johnei

1960 • 19 citations

Putative functional domain within ORF2 on the Mycobacterium insertion sequences IS900 and IS902

1994 • 18 citations

Lipids from Mycobacterium leprae cell wall suppress T‐cell activation in vivo and in vitro

1997 • 18 citations

Antimycobacterial Synergism of Clarithromycin and Rifabutin

1996 • 18 citations

The causation of Crohn's disease and treatment with antimicrobial drugs.

1998 • 18 citations

Treatment of severe Crohn's disease (CD) using rifabutin-macrolide-clofazimine combination: Interim report

1998 • 17 citations

Clofazimine treatment of cows naturally infected with Mycobacterium paratuberculosis.

1973 • 17 citations

Mycobacterium paratuberculosis isole chez des patients atteints de maladie de Crohn Résultats préliminaires

1991 • 17 citations

Combined Streptomycin-Isoniazid-Rifampin Therapy in the Treatment of Johne's Disease in a Goat.

1982 • 17 citations

[Mycobacterium paratuberculosis in the intestine of patients with Crohn's disease].

1997 • 17 citations

Crohn's disease. Rifampin treatment of the ocular and gut disease.

1987 • 16 citations

Prolonged remission in Crohn's disease following therapy for mycobacterium paratuberculosis infection

1995 • 15 citations

Subcutaneous exposure of calves to Myobacterium paratuberculosis compared with intravenous and oral exposures.

1977 • 14 citations

Relationship between Mycobacterium avium, M. paratuberculosis and mycobacteria associated with Crohn's disease.

1989 • 14 citations

Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of Mycobacterium avium complex

1995 • 14 citations

Heat resistance of Listeria monocytogenes by two recovery media used with and without cold preincubation

1993 • 14 citations

Intracellular Accumulation of Azithromycin by Cultured Human Fibroblasts

1990 • 14 citations

Distribution of crohn's disease in Cardiff

1978 • 14 citations

Differentiation of Mycobacterium paratuberculosis isolates by rDNA-spacer analysis and random amplified polymorphic DNA patterns

1997 • 13 citations

The presence and severity of neural inflammation predict severe postoperative recurrence of Crohn's disease

1998 • 12 citations

Solving the dilemma of antimycobacterial chemotherapy

1996 • 12 citations

Effect of the rimino phenazine B663 (G30320) on Mycobacterium johnei infection and reinfection in sheep

1971 • 11 citations

Paratuberculosis in Sheep Flocks in Morocco: a Serological, Microscopical and Cultural Survey

1996 • 11 citations

The effect of isonicotinic acid hydrazide on Mycobacterium paratuberculosis.

1953 • 11 citations

Development of a transposon mutagenesis system for Mycobacterium avium subsp. paratuberculosis

1999 • 9 citations

Preliminary studies on the effect of streptomycin and other agents on Mycobacterium paratuberculosis.

1950 • 8 citations

Molecular mechanism of nerve infection in leprosy

1999 • 7 citations

Mycobacterium Paratuberculosis and Crohn’s Disease

1992 • 6 citations

Therapy for Johne's disease

1990 • 6 citations

Effect of combination therapy in Mycobacterium paratuberculosis infected rabbits.

1994 • 6 citations

Isoniazid therapy in two cases of Johne's disease.

1976 • 5 citations

The failure of the rimino phenazine B663 (G30320) to reduce the level of experimental Mycobacterium johnei infections in calves.

1970 • 4 citations

A Hypothesis for Explaining the Geographical Distribution of Crohn’s Disease

1996 • 4 citations

Relationship between Mycobacterium avium, M. paratuberculosis and mycobacteria associated with Crohn's disease.

1989 • 4 citations

Chemotherapy of paratuberculosis in goats: streptomycin, rifampicin and levamisole versus streptomycin, rifampicin and dapsone.

1992 • 4 citations

THE ADEQUACY OF COMMERCIAL PASTEURISATION FOR DESTRUCTION OF TUBERCLE BACILLI

1937 • 3 citations

Deleted Work

1955 • 0 citations