Angiogenesis-Regulating Cytokines: Activities and Interactions

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Angiogenic Factors

1987 • 3,702 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

J. Submicrosc. Cytol. Pathol.

2000 • 2,783 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins

1992 • 1,612 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

1987 • 1,287 citations

Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis

1977 • 1,286 citations

Structural and Functional Diversity in the FGf Receptor Multigene Family

1992 • 1,262 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.

1988 • 1,209 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

Interferon Alfa-2a Therapy for Life-Threatening Hemangiomas of Infancy

1992 • 1,076 citations

Angiogenesis in vitro

1980 • 1,041 citations

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1995 • 1,026 citations

Regulators of Angiogenesis

1991 • 959 citations

Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro

1992 • 865 citations

Vascular permeability factor (VPF, VEGF) in tumor biology

1993 • 839 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Basic fibroblast growth factor induces angiogenesis in vitro.

1986 • 828 citations

Cytokines in context.

1991 • 808 citations

A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor.

1992 • 807 citations

Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.

1987 • 791 citations

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.

1994 • 784 citations

Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth

1987 • 764 citations

Tumor Growth and Neovascularization: An Experimental Model Using the Rabbit Cornea 2

1974 • 762 citations

Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

1992 • 760 citations

Murine FGFR-1 is required for early postimplantation growth and axial organization.

1994 • 748 citations

Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis.

1995 • 699 citations

Vascular endothelial growth factor and its receptors

1996 • 686 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies

1988 • 667 citations

Cellular markers that distinguish the phases of hemangioma during infancy and childhood.

1994 • 651 citations

Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis.

1988 • 647 citations

Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction

1992 • 625 citations

In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices.

1983 • 616 citations

Synergistic Effect of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor on Angiogenesis In Vivo

1995 • 605 citations

Growth of microvessels in serum-free matrix culture of rat aorta. A quantitative assay of angiogenesis in vitro.

1990 • 599 citations

Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide.

1995 • 590 citations

Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix.

1988 • 571 citations

Endothelial proliferation in tumours and normal tissues: Continuous labelling studies

1984 • 562 citations

Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse

1992 • 552 citations

Endothelial receptor tyrosine kinases involved in angiogenesis.

1995 • 537 citations

Distribution of basic fibroblast growth factor in the 18-day rat fetus: localization in the basement membranes of diverse tissues.

1990 • 533 citations

Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

1994 • 494 citations

Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses.

1987 • 491 citations

Elevated Levels of an Angiogenic Peptide, Basic Fibroblast Growth Factor, in the Urine of Patients With a Wide Spectrum of Cancers

1994 • 478 citations

Tumor-promoting phorbol esters induce angiogenesis in vitro

1985 • 470 citations

Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane.

1990 • 470 citations

Tumor Angiogenesis

1974 • 470 citations

Proceedings: Tumor angiogenesis factor.

1974 • 469 citations

Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro.

1990 • 466 citations

Vascular endothelial growth factor and glioma angiogenesis: Coordinate induction of VEGF receptors, distribution of VEGF protein and possibleIn vivo regulatory mechanisms

1994 • 464 citations

Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels.

1993 • 463 citations

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

1989 • 462 citations

Relationship between vasculogenesis, angiogenesis and haemopoiesis during avian ontogeny

1989 • 460 citations

Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.

1990 • 450 citations

Treatment of Pulmonary Hemangiomatosis with Recombinant Interferon Alfa-2a

1989 • 444 citations

Complexity of FGF receptors: genetic basis for structural diversity and functional specificity

1992 • 441 citations

Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets

1986 • 439 citations

Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth.

1993 • 437 citations

The alphas, betas, and kinases of cytokine receptor complexes

1993 • 418 citations

Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis

1988 • 410 citations

Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers.

1986 • 401 citations

Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts.

1994 • 393 citations

Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia.

1993 • 387 citations

Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration.

1986 • 354 citations

Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms

1990 • 342 citations

LIF: lots of interesting functions

1992 • 341 citations

Biphasic Effect of Transforming Growth Factor-β1 on in Vitro Angiogenesis

1993 • 338 citations

Inhibition of Cell Motility by Interferon

1980 • 331 citations

Inhibitory action of transforming growth factor beta on endothelial cells.

1987 • 324 citations

Transforming growth factor-beta inhibits endothelial cell proliferation

1986 • 313 citations

Inhibition of endothelial cell proliferation by type β-transforming growth factor: Interactions with acidic and basic fibroblast growth factors

1986 • 312 citations

Cell turnover of capillaries.

1967 • 294 citations

Inhibition of endothelial cell proliferation by gamma-interferon.

1987 • 292 citations

TGF-β receptors and actions

1994 • 291 citations

TGF-β-receptor-mediated signaling

1994 • 274 citations

Vascular Endothelial Growth Factor Increases Urokinase Receptor Expression in Vascular Endothelial Cells

1995 • 269 citations

Cytokine receptors and signal transduction

1992 • 269 citations

Suppression of solid tumor growth by immunoneutralizing monoclonal antibody against human basic fibroblast growth factor.

1991 • 268 citations

Expression of basic fibroblast growth factor in normal human tissues.

1990 • 258 citations

Functions of fibroblast growth factors and their receptors

1995 • 254 citations

Oncostatin M as a Potent Mitogen for AIDS-Kaposi's Sarcoma-Derived Cells

1992 • 251 citations

Both normal and tumor cells produce basic fibroblast growth factor

1986 • 250 citations

First steps of tumor-related angiogenesis.

1991 • 241 citations

Molecular Mechanisms of Developmental and Tumor Angiogenesis

1994 • 241 citations

Effects of growth factors in vivo. I. Cell ingrowth into porous subcutaneous chambers.

1987 • 239 citations

Transforming growth factor-beta (TGFβ) is chemotactic for human monocytes and induces their expression of angiogenic activity

1988 • 233 citations

Blood Vessel Fibronectin Increases in Conjunction with Endothelial Cell Proliferation and Capillary Ingrowth During Wound Healing

1982 • 211 citations

Cytokine networks in solid human tumors: regulation of angiogenesis

1994 • 209 citations

Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity.

1992 • 205 citations

Aortic endothelial cell replication. I. Effects of age and hypertension in the rat.

1977 • 204 citations

Proteolytic balance and capillary morphogenesis

1990 • 203 citations

Differential expression of extracellular proteins is correlated with angiogenesis in vitro.

1991 • 199 citations

Vascular endothelial growth factor/vascular permeability factor is detectable in the sera of tumor-bearing mice and cancer patients

1994 • 198 citations

Fibroblast growth factors and their receptors: An information network controlling tissue growth, morphogenesis and repair

1994 • 195 citations

Comparison of the biological actions of TGF beta‐1 and TGF beta‐2: Differential activity in endothelial cells

1988 • 195 citations

Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic FGF with plaque microvessels and macrophages.

1993 • 194 citations

Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions.

1993 • 192 citations

Early events in signalling by interferons

1993 • 186 citations

Transforming growth factor beta₁ modulates extracellular matrix organization and cell‐cell junctional complex formation during in vitro angiogenesis

1990 • 184 citations

Interleukln-8 stimulates angiogenesis in rats

1993 • 182 citations

On the development of the aortae, cardinal and umbilical veins, and the other blood vessels of vertebrate embryos from capillaries

1909 • 182 citations

TGF-β Regulates Production of Growth Factors and TGF-β by Human Peripheral Blood Monocytes

1990 • 178 citations

Treatment of childhood angiomatous diseases with recombinant interferon alfa-2a

1991 • 175 citations

Expression of basic fibroblast growth factor and its receptor by smooth muscle cells and endothelium in injured rat arteries. An en face study.

1993 • 174 citations

Significance of Vascular Endothelial Growth Factor/Vascular Permeability Factor for Solid Tumor Growth, and Its Inhibition by the Antibody

1993 • 174 citations

In situ detection of basic fibroblast growth factor by highly specific antibodies.

1990 • 168 citations

Distribution of interferon‐γ receptor in human tissues

1992 • 168 citations

Monoclonal antibodies against heparin-binding growth factor II/basic fibroblast growth factor that block its biological activity: invalidity of the antibodies for tumor angiogenesis.

1989 • 166 citations

Hypoxia and platelet‐derived growth factor‐BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells

1995 • 165 citations

Binding of Transforming Growth Factor-β to Cell Surface Proteins Varies with Cell Type

1989 • 160 citations

Tumor angiogenesis activity in cells grown in tissue culture.

1976 • 159 citations

Fibronectin is produced by blood vessels in response to injury.

1982 • 155 citations

Excessive production of transforming growth-factor β1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth

1992 • 147 citations

Comparative Analysis of Vascular Endothelial Growth Factor Receptors on Retinal and Aortic Vascular Endothelial Cells

1995 • 146 citations

Organized type I collagen influences endothelial patterns during “spontaneous angiogenesis in vitro”: Planar cultures as models of vascular development

1995 • 146 citations

Increased levels of fibroblast growth factor-like activity in urine from patients with bladder or kidney cancer.

1988 • 146 citations

Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells

1994 • 144 citations

Quantitative in-vivo studies on angiogenesis in a rat sponge model.

1987 • 143 citations

Peptide Growth Factors and Their Receptors II

1990 • 142 citations

Release of basic fibroblast growth factor, an angiogenic factor devoid of secretory signal sequence: A trivial phenomenon or a novel secretion mechanism?

1991 • 140 citations

Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.

1991 • 137 citations

Tumor angiogenesis: the role of oncogenes and tumor suppressor genes.

1990 • 135 citations

Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells.

1994 • 133 citations

Therapeutic Angiogenesis

1993 • 132 citations

Interleukin-6 gene expression in human endothelial cells: RNA start sites, multiple IL-6 proteins and inhibition of proliferation

1989 • 131 citations

TGF-β1 Overexpression in Murine Pancreas Induces Chronic Pancreatitis and Together with TNF-α, Triggers Insulin-Dependent Diabetes

1995 • 125 citations

Synergistic effect of retinoids and interferon α on tumor‐induced angiogenesis: Anti‐angiogenic effect on HPV‐harboring tumor‐cell lines

1994 • 123 citations

Pituitary follicular cells secrete an inhibitor of aortic endothelial cell growth: identification as leukemia inhibitory factor.

1992 • 122 citations

Phorbol ester induces cultured endothelial cells to invade a fibrin matrix in the presence of fibrinolytic inhibitors

1987 • 121 citations

Endothelial Cells Synthesize Basic Fibroblast Growth Factor and Transforming Growth Factor Beta

1988 • 119 citations

Diverse receptors for fibroblast growth factors

1992 • 119 citations

Regulation of Endothelial Cell Growth, Architecture, and Matrix Synthesis by TGF-β

1989 • 116 citations

Endothelial cells exhibiting angiogenesis in vitro proliferate in response to TGF‐β1

1993 • 108 citations

Alternative splicing generates at least five different isoforms of the human basic-FGF receptor.

1991 • 104 citations

Expression of basic and acidic fibroblast growth factors and their receptor in normal and atherosclerotic human arteries

1993 • 104 citations

Fibroblast growth factor receptor gene expression and immunoreactivity are elevated in human glioblastoma multiforme.

1994 • 104 citations

Basic fibroblast growth factor and transforming growth factor beta‐1: Synergistic mediators of angiogenesis in vitro

1993 • 101 citations

Interferon–Alpha-2a for the Treatment of Complex Hemangiomas of Infancy and Childhood

1994 • 101 citations

Immunolocalization of basic fibroblast growth factor to the micro vasculature of human brain tumors

1992 • 100 citations

Abscesses of the Valve Rings of the Heart, a Frequent but Not Well Recognized Complication of Acute Bacterial Endocarditis

1951 • 100 citations

Leukemia inhibitory factor (LIF) inhibits angiogenesis in vitro

1995 • 98 citations

Targeted expression of transforming growth factor-beta 1 in intracardiac grafts promotes vascular endothelial cell DNA synthesis.

1995 • 97 citations

Heparan sulfate proteoglycans as transducers of FGF-2 signalling

1994 • 94 citations

Angiogenic growth factors in neural embryogenesis and neoplasia.

1995 • 94 citations

Differential temporal and spatial gene expression of fibroblast growth factor family members during mouse mammary gland development.

1994 • 93 citations

Immunocytochemical localization of basic fibroblast growth factor in carcinomas and inflammatory lesions of the human digestive tract.

1993 • 92 citations

Interferon-alpha and interleukin 2 synergistically enhance basic fibroblast growth factor synthesis and induce release, promoting endothelial cell growth.

1993 • 91 citations

High affinity immunoreactive FGF receptors in the extracellular matrix of vascular endothelial cells--implications for the modulation of FGF-2.

1995 • 89 citations

Localization of basic fibroblast growth factor to the developing capillaries of the bovine retina

1989 • 88 citations

Modulation of bovine microvascular endothelial cell proteolytic properties by inhibitors of angiogenesis

1994 • 87 citations

The murine type II TGF-β receptor has a coincident embryonic expression and binding preference for TGF-β1

1994 • 87 citations

Immunolocalization of fibroblast growth factor receptor 1 and its ligands in human tissues.

1993 • 85 citations

The antiproliferative effect of interferon and the mitogenic activity of growth factors are independent cell cycle events

1985 • 84 citations

Endothelial cell regulation by transforming growth factor‐beta

1991 • 81 citations

Chondrocytes inhibit endothelial sprout formation in vitro: Evidence for involvement of a transforming growth factor‐beta

1991 • 75 citations

Effects of rIFN Alpha, Beta, and Gamma on the Morphology, Proliferation, and Cell Surface Antigen Expression of Human Dermal Microvascular Endothelial Cells In Vitro

1990 • 75 citations

Monoclonal antibodies directed against basic fibroblast growth factor which inhibit its biological activity in vitro and in vivo

1989 • 72 citations

In vivo and in vitro characteristics of interleukin 6-transfected B16 melanoma cells.

1992 • 71 citations

How Interferons Fight Disease

1994 • 68 citations

Localization of Basic Fibroblast Growth Factor in Bovine Endothelial Cells: Immunohistochemical and Biochemical Studies

1993 • 68 citations

Suppression of VEGF‐induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A

1995 • 66 citations

Expression of Fibroblast Growth Factor Receptor-1 in Human Glioma and Meningioma Tissues

1994 • 64 citations

Leukaemia inhibitory factor and interleukin 6 are expressed at very low levels in the normal adult mouse and are induced by inflammation

1994 • 62 citations

Culture‐induced increase in acidic and basic fibroblast growth factor activities and their association with the nuclei of vascular endothelial and smooth muscle cells

1991 • 61 citations

Effects of a variety of cytokines and inducing agents on vascular permeability factor mRNA levels in U937 cells

1991 • 61 citations

Beta-fibroblast growth factor expression in human and murine squamous cell carcinomas and its relationship to regional endothelial cell proliferation.

1993 • 60 citations

Molecular dissection of multi-stage tumorigenesis in transgenic mice.

1994 • 55 citations

Comparison of gene expression in bovine aortic endothelium in vivo versus in vitro. Differences in growth regulatory molecules.

1993 • 52 citations

Bifunctional effects of transforming growth factor-β (TGF-β) on endothelial cell growth correlate with phenotypes of TGF-β binding sites

1990 • 51 citations

Basic FGF Treatment of Endothelial Cells Down-regulates the 85-KDa TGFβ Receptor Subtype and Decreases the Growth Inhibitory Response to TGF-β1

1990 • 48 citations

Extracellular matrix and capillary ingrowth in interspecies chimeric kidneys

1984 • 48 citations

TGF-( -receptor-mediated signaling

1994 • 46 citations

MOLECULAR BIOLOGY OF THE CARDIOVASCULAR SYSTEM

1991 • 41 citations

Interleukin-6 stimulates motility of vascular endothelium

1991 • 40 citations

Studies on the role of basic fibroblast growth factor in vivo: Inability of neutralizing antibodies to block tumor growth

1990 • 40 citations

Vascular Cell Responses to TGF-β₃Mimic Those of TGF-β₁in vitro

1991 • 37 citations

Transforming growth factor beta (TGF-B) stimulation of angiogenesis: an electron microscopic study.

1993 • 32 citations

Inhibition by Methylprednisolone Acetate Suggests an Indirect Mechanism for TGF-B Induced Angiogenesis

1992 • 32 citations

Expression of interferon-γ receptor in normal and pathological human liver tissue

1991 • 31 citations

A glycosylation-deficient endothelial cell mutant with modified responses to transforming growth factor-beta and other growth inhibitory cytokines: evidence for multiple growth inhibitory signal transduction pathways.

1993 • 30 citations

D-factor/leukaemia inhibitory factor: Evidence for its role as a mediator in acute and chronic inflammatory disease

1994 • 27 citations

Immunolocalization of basic fibroblast growth factor and platelet-derived growth factor-A during adjuvant arthritis in the Lewis rat.

1994 • 21 citations

Transforming growth factor β1-specific binding proteins on human vascular endothelial cells

1992 • 21 citations

Expression of type II transforming growth factor-β receptor mRNA in human skin, as revealed by in situ hybridization

1994 • 18 citations

Angiogenesis: potential therapy for ischaemic disease

1994 • 14 citations

Interferons

1990 • 12 citations

Angiogenesis in Vitro: Cytokine Interactions and Balanced Extracellular Proteolysis

1994 • 8 citations

Surface aminopeptidase activity of rat natural killer cells I. Biochemical and biological properties

1994 • 7 citations