RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor

High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules.

1979 • 1,504 citations

Yeast transformation: a model system for the study of recombination.

1981 • 1,491 citations

Mechanism of activation of a human oncogene

1982 • 1,417 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

In yeast, RAS proteins are controlling elements of adenylate cyclase

1985 • 1,142 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

Protein translocation across the endoplasmic reticulum

1984 • 825 citations

Order of events in the yeast secretory pathway

1981 • 804 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

Structure and activation of the human N-ras gene

1983 • 538 citations

A novel ras-related gene family

1985 • 487 citations

Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins

1984 • 471 citations

DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase

1985 • 429 citations

Glycosylation and processing of prepro-α-factor through the yeast secretory pathway

1984 • 410 citations

Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry

1980 • 404 citations

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

1984 • 403 citations

Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins

1985 • 365 citations

The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid

1982 • 357 citations

Functional homology of mammalian and yeast RAS genes

1985 • 324 citations

Isolation and Genetic Analysis of Saccharomyces cerevisiae Mutants Supersensitive to G1 Arrest by a Factor and α Factor Pheromones

1982 • 322 citations

The protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells (pp60proto-src) are associated with the plasma membrane.

1980 • 298 citations

Developmental regulation of a dictyostelium gene encoding a protein homologous to mammalian ras protein

1984 • 267 citations

Amino Terminal Myristylation of the Protein Kinase p60 src , a Retroviral Transforming Protein

1985 • 264 citations

Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae.

1987 • 259 citations

Transcription and regulatory signals at the mating type locus in yeast

1984 • 256 citations

Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog

1985 • 223 citations

Rous sarcoma virus transforming protein lacking myristic acid phosphorylates known polypeptide substrates without inducing transformation

1986 • 223 citations

Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin.

1984 • 214 citations

Experimental Manipulation of Gene Expression

1983 • 213 citations

MUTATIONS AFFECTING SEXUAL CONJUGATION AND RELATED PROCESSES IN SACCHAROMYCES CEREVISIAE. I. ISOLATION AND PHENOTYPIC CHARACTERIZATION OF NONMATING MUTANTS

1974 • 204 citations

Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src).

1981 • 203 citations

Comparative biochemical properties of p21 ras molecules coded for by viral and cellular ras genes

1982 • 179 citations

Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.

1982 • 178 citations

Direct identification of palmitic acid as the lipid attached to p21ras.

1986 • 157 citations

Transient G1 arrest of S. cerevisiae cells of mating type α by a factor produced by cells of mating type a

1974 • 156 citations

Identification of a precursor in the biosynthesis of the p21 transforming protein of harvey murine sarcoma virus

1982 • 151 citations

Molecular cloning and sequence analysis of a ras gene from Schizosaccharomyces pombe.

1985 • 138 citations

Peptidal Sex Hormones Inducing Conjugation Tube Formation in Compatible Mating-Type Cells of Tremella mesenterica

1981 • 125 citations

Vectors for High-Level, Inducible Expression of Cloned Genes in Yeast

1983 • 114 citations

Processing and fatty acid acylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae.

1986 • 108 citations

Negative regulation of STE6 gene expression by the alpha 2 product of Saccharomyces cerevisiae.

1984 • 93 citations

Protein Transport and Secretion

1986 • 92 citations

A heat shock-resistant mutant of Saccharomyces cerevisiae shows constitutive synthesis of two heat shock proteins and altered growth.

1984 • 73 citations

Characterization of functional domains of p21 ras by use of chimeric genes.

1985 • 60 citations

Structure of rhodotorucine A, a peptidyl factor, inducing mating tube formation in Rhodosporidium toruloides.

1979 • 57 citations

Structure of RhodotorucineA, a Peptidyl Factor, Inducing Mating Tube Formation inRhodosporidium toruloides

1979 • 43 citations

Hormonal control of gametogenesis in the yeast Saccharomyces cerevisiae

1981 • 40 citations

Expression of normal and activated human Ha-ras cDNAs in Saccharomyces cerevisiae.

1985 • 33 citations

[63] Fatty acid acylation of eukaryotic cell proteins

1983 • 17 citations