The Nitric Oxide Pathway in the Control of Myocardial Function: Role of Cytokines

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

1992 • 2,138 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Profound but Reversible Myocardial Depression in Patients with Septic Shock

1984 • 1,518 citations

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

1992 • 1,454 citations

The Pathogenesis of Sepsis

1991 • 1,376 citations

Nitric oxide synthase structure and mechanism

1993 • 1,342 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

1993 • 1,077 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Management of patients with intramural hematoma of the thoracic aorta.

1993 • 896 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14.

1993 • 845 citations

Isoforms of nitric oxide synthase Characterization and purification from different cell types

1991 • 827 citations

Cytokines in context.

1991 • 808 citations

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

1993 • 778 citations

Nitric oxide, a novel biologic messenger

1992 • 754 citations

Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.

1993 • 708 citations

Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta.

1993 • 658 citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

1990 • 657 citations

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.

1993 • 656 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock.

1989 • 567 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Transport of cationic amino acids by the mouse ecotropic retrovirus receptor

1991 • 552 citations

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1990 • 536 citations

Effects of a nitric oxide synthase inhibitor in humans with septic shock

1994 • 521 citations

Mammalian Nitric Oxide Synthases

1992 • 514 citations

Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness.

1989 • 493 citations

Isoforms of nitric oxide synthase

1995 • 482 citations

Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes.

1991 • 475 citations

The coronary circulation in human septic shock.

1986 • 466 citations

Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium.

1993 • 457 citations

Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.

1992 • 444 citations

Cell-surface receptor for ecotropic murine retroviruses is a basic amino-acid transporter

1991 • 439 citations

Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro.

1994 • 436 citations

A specific receptor antagonist for interleukin 1 prevents Escherichia coli ‐induced shock in rabbits

1991 • 435 citations

IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity.

1992 • 422 citations

Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?

1991 • 409 citations

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.

1993 • 393 citations

Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock.

1987 • 370 citations

Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages.

1990 • 356 citations

Guanylyl cyclase receptors and their endocrine, paracrine, and autocrine ligands

1992 • 346 citations

Modulation of Nitrogen Oxide Synthesis In Vivo: NG-Monomethyl-L-Arginine Inhibits Endotoxin-Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage

1990 • 345 citations

Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia

1992 • 327 citations

Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.

1990 • 288 citations

The transport of cationic amino acids across the plasma membrane of mammalian cells

1985 • 287 citations

Depressed Left Ventricular Performance

1988 • 280 citations

Interferon-gamma and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells.

1992 • 276 citations

Left ventricular systolic and diastolic dysfunction after infusion of tumor necrosis factor-alpha in conscious dogs.

1992 • 275 citations

Nitrite Inhibition of Clostridium botulinum : Electron Spin Resonance Detection of Iron-Nitric Oxide Complexes

1983 • 261 citations

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.

1991 • 257 citations

Pathophysiology of Shock, Sepsis, and Organ Failure

1993 • 216 citations

An obligatory role for nitric oxide in autonomic control of mammalian heart rate.

1994 • 215 citations

Mechanism of cytokine inhibition of beta-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes. Impairment of signal transduction.

1990 • 215 citations

Administration of Anti-TNF Antibody Improves Left Ventricular Function in Septic Shock Patients

1992 • 214 citations

Left ventricular performance in septic shock: Reversible segmental and global abnormalities

1985 • 212 citations

Interleukin-2 Administration Causes Reversible Hemodynamic Changes and Left Ventricular Dysfunction Similar to Those Seen in Septic Shock

1988 • 186 citations

Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes.

1992 • 186 citations

Platelet-derived growth factor suppresses and fibroblast growth factor enhances cytokine-induced production of nitric oxide by cultured smooth muscle cells. Effects on cell proliferation.

1992 • 172 citations

A Circulating Myocardial Depressant Substance is Associated with Cardiac Dysfunction and Peripheral Hypoperfusion (Lactic Acidemia) in Patients with Septic Shock

1989 • 166 citations

Transforming growth factor β2 inhibits interleukin 1β- and tumour necrosis factor α-induction of nitric oxide synthase in rat renal mesangial cells

1991 • 162 citations

Histopathology of early myocardial infarcts. A new approach.

1974 • 156 citations

Role of nitric oxide in antagonistic effects of transforming growth factor-beta and interleukin-1 beta on the beating rate of cultured cardiac myocytes.

1992 • 150 citations

Evidence that an <scp>l</scp>‐arginine/nitric oxide dependent elevation of tissue cyclic GMP content is involved in depression of vascular reactivity by endotoxin

1991 • 140 citations

Isolation and characterization of human and rat cardiac microvascular endothelial cells

1993 • 137 citations

Detection of Tumour Necrosis Factor‐Like Cytotoxicity in Serum from Patients With Septicaemia but Not from Untreated Cancer Patients

1986 • 130 citations

Detection of NG, NG-Dimethylarginine Dimethylaminohydrolase in the Nitric Oxide-Generating Systems of Rats Using Monoclonal Antibody

1993 • 128 citations

Differential mechanisms of intracellular killing ofMycobacterium aviumandListeria monocytogenesby activated human and murine macrophages. The role of nitric oxide

1993 • 122 citations

Myocardial depression characterizes the fatal course of septic shock.

1992 • 117 citations

Continual electric field stimulation preserves contractile function of adult ventricular myocytes in primary culture

1994 • 117 citations

Recombinant Human Tumor Necrosis Factor Produces Hemodynamic Changes Characteristic of Sepsis and Endotoxemia

1989 • 115 citations

Tetrahydrobiopterin and Cytokines

1993 • 108 citations

Decreased contractility and compliance of the left ventricle as complications of thermal trauma

1984 • 106 citations

Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1 beta and IFN-gamma

1995 • 100 citations

Characterization of endothelial cell amino acid transport systems involved in the actions of nitric oxide synthase inhibitors.

1993 • 85 citations

Cardiovascular performance with E. coli challenges in a canine model of human sepsis

1988 • 83 citations

Maldistribution of heterogeneous coronary blood flow during canine endotoxin shock

1991 • 81 citations

Properties of cardioinhibitory factors produced in shock.

1978 • 79 citations

Cell-cell signaling between adult rat ventricular myocytes and cardiac microvascular endothelial cells in heterotypic primary culture.

1993 • 74 citations

Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: inhibition by transforming growth factor-ß

1992 • 72 citations

Tumor necrosis factor α up-regulates Giα and Gß proteins and adenylyl cyclase responsiveness in rat cardiomyocytes

1991 • 64 citations

Role of nitric oxide in antagonistic effects of transforming growth factor-beta and interleukin-1 beta on the beating rate of cultured cardiac myocytes

1992 • 55 citations

Repeated induction of nitric oxide synthase and leishmanicidal activity in murine macrophages

1993 • 43 citations

Influence of a Myocardial Depressant Factor on Physiologic Properties of Cardiac Muscle

1970 • 42 citations

A cardiodepressant factor isolated from blood blocks Ca2+ current in cardiomyocytes

1991 • 38 citations

Cardiac contractile injury after intestinal ischemia-reperfusion

1991 • 36 citations

Mechanism of cardiac dysfunction in hearts from endotoxin-treated rats.

1986 • 35 citations

Role of Endotoxin and Host Cytokines in Septic Shock

1991 • 35 citations

Electron paramagnetic resonance spectroscopic investigation of the inhibition of the phosphoroclastic system of Clostridium sporogenes by nitrite

1990 • 32 citations

Left ventricular contractility is depressed in IgE-mediated anaphylactic shock in dogs

1991 • 29 citations

Mechanisms of Kupffer cell cytotoxicity in vitro against the syngeneic murine colon adenocarcinoma line MCA26

1993 • 27 citations

The macrophage response to infectious agents: mechanisms of macrophage activation and tumour cell killing

1993 • 25 citations

Immune cytokines and cardiac disease

1992 • 24 citations

Cholinergic response of isolated rat atria to recombinant rat interferon-γ

1991 • 19 citations

Load-insensitive assessment of myocardial performance after tumor necrosis factor-alpha in dogs.

1992 • 17 citations

A Phase I Study of Human Natural Interferon-β in Cancer Patients

1989 • 16 citations

Does the heart fail in endotoxin shock?

1990 • 15 citations

“Negative Inotropic Cascades” in Cardiomyocytes Triggered by Substances Relevant to Sepsis

1993 • 14 citations

Left ventricular performance in canine endotoxin shock.

1988 • 13 citations

Pathomorphological Aspects of the Heart in Septic Patients

1993 • 12 citations

Physiologic and plasma hormone correlates of survival in endotoxic dogs: effects of opiate antagonists.

1989 • 12 citations

Studies on low molecular weight inotropic plasma substances in prolonged hypovolemic traumatic shock.

1987 • 7 citations

Interferon-γ down-regulates membrane adenylate cyclase activity of a murine macrophage-like cell line (P388D1)

1989 • 5 citations

Potentiated cardiodepressant effect of serum by endotoxin in adrenalectomized rats.

1986 • 5 citations

Role of endotoxin and host cytokines in septic shock

1991 • 3 citations