Delineation of the arginine- and tetrahydrobiopterin-binding sites of neuronal nitric oxide synthase

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Nitric oxide synthases in mammals

1994 • 2,762 citations

Rapid measurement of binding constants and heats of binding using a new titration calorimeter

1989 • 2,603 citations

Crystal Structure of Hemoprotein Domain of P450BM-3, a Prototype for Microsomal P450's

1993 • 876 citations

Nitric oxide synthase: Aspects concerning structure and catalysis

1994 • 865 citations

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1992 • 617 citations

Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase

1991 • 422 citations

Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme.

1993 • 391 citations

Endothelial Nitric-oxide Synthase

1996 • 322 citations

Automatic generation of primary sequence patterns from sets of related protein sequences.

1990 • 292 citations

Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer.

1995 • 292 citations

Pattern-induced multi-sequence alignment (PUMA) algorithm employing secondary structure-dependent gap penalties for use in comparative protein modelling

1992 • 281 citations

Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine

1993 • 274 citations

High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli.

1995 • 233 citations

The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain.

1994 • 218 citations

Evidence for a bidomain structure of constitutive cerebellar nitric oxide synthase.

1994 • 201 citations

Characterization of Heme-deficient Neuronal Nitric-oxide Synthase Reveals a Role for Heme in Subunit Dimerization and Binding of the Amino Acid Substrate and Tetrahydrobiopterin

1996 • 184 citations

Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases.

1987 • 180 citations

Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity

1992 • 174 citations

Prokaryotic Expression of the Heme- and Flavin-Binding Domains of Rat Neuronal Nitric Oxide Synthase as Distinct Polypeptides: Identification of the Heme-Binding Proximal Thiolate Ligand as Cysteine-415

1995 • 163 citations

Macrophage NO synthase: characterization of isolated oxygenase and reductase domains reveals a head-to-head subunit interaction

1995 • 149 citations

Cysteine 184 of endothelial nitric oxide synthase is involved in heme coordination and catalytic activity.

1994 • 117 citations

Molecular evolution of P450 superfamily and P450‐containing monooxygenase systems

1993 • 111 citations

Particular Ability of Liver P450s3a to Catalyze the Oxidation of Nω-Hydroxyarginine to Citrulline and Nitrogen Oxides and Occurrence in NO Synthases of a Sequence Very Similar to the Heme-Binding Sequence in P450s

1993 • 101 citations

Characterization of Neuronal Nitric Oxide Synthase and a C415H Mutant, Purified from a Baculovirus Overexpression System

1994 • 97 citations

Pseudomonas aeruginosa possesses homologues ofmammalian phenylalanine hydroxylase and 4 alpha-carbinolamine dehydratase/DCoHas part of a three-component gene cluster.

1994 • 92 citations

Cysteine 99 of Endothelial Nitric Oxide Synthase (NOS-III) Is Critical for Tetrahydrobiopterin-Dependent NOS-III Stability and Activity

1995 • 86 citations

Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin.

1995 • 77 citations

A single locus encodes both phenylalanine hydroxylase and tryptophan hydroxylase activities in Drosophila.

1992 • 73 citations

Tetrahydrobiopterin-deficient nitric oxide synthase has a modified heme environment and forms a cytochrome P 420 analog

1995 • 65 citations

Expression of rat brain nitric oxide synthase in baculovirus-infected insect cells and characterization of the purified enzyme

1994 • 58 citations

Use of the Glu-Glu-Phe C-terminal epitope for rapid purification of the catalytic domain of normal and mutant ras GTPase-activating proteins

1991 • 56 citations

Delineation of the catalytic core of phenylalanine hydroxylase and identification of glutamate 286 as a critical residue for pterin function.

1994 • 51 citations

Modular Structure of Neuronal Nitric Oxide Synthase: Localization of the Arginine Binding Site and Modulation by Pterin

1995 • 50 citations

Purification to Homogeneity and Characterisation of Rat Brain Recombinant Nitric Oxide Synthase

1995 • 49 citations

Purification to Homogeneity and Characterisation of Rat Brain Recombinant Nitric Oxide Synthase

1995 • 47 citations

Regulation of rat liver phenylalanine hydroxylase. II. Substrate binding and the role of activation in the control of enzymatic activity.

1994 • 45 citations

Cloning and Expression of a Rat Neuronal Nitric Oxide Synthase Coding Sequence in a Baculovirus/Insect Cell System

1993 • 43 citations

Localization of cofactor binding sites with monoclonal anti-idiotype antibodies: phenylalanine hydroxylase.

1991 • 37 citations

Identification of the domains of neuronal nitric oxide synthase by limited proteolysis

1996 • 36 citations

Regulation of rat liver phenylalanine hydroxylase. I. Kinetic properties of the enzyme's iron and enzyme reduction site.

1994 • 36 citations

Determination of biopterin and other pterins in tissues and body fluids by high-performance liquid chromatography

1983 • 34 citations

Overexpression of neuronal nitric oxide synthase in insect cells reveals requirement of haem for tetrahydrobiopterin binding

1996 • 30 citations

Cysteine-200 of human inducible nitric oxide synthase is essential for dimerization of haem domains and for binding of haem, nitroarginine and tetrahydrobiopterin

1997 • 23 citations