Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma

Histological grading and staging of chronic hepatitis

1995 • 4,862 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

PD-1 and Its Ligands in Tolerance and Immunity

2008 • 4,838 citations

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

2007 • 1,375 citations

Programmed cell death 1 ligand 1 and tumor-infiltrating CD8⁺T lymphocytes are prognostic factors of human ovarian cancer

2007 • 1,317 citations

Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection

1999 • 1,208 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

Clinical Significance and Therapeutic Potential of the Programmed Death-1 Ligand/Programmed Death-1 Pathway in Human Pancreatic Cancer

2007 • 843 citations

A "quickscore" method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast carcinomas.

1995 • 827 citations

Overexpression of PD-L1 Significantly Associates with Tumor Aggressiveness and Postoperative Recurrence in Human Hepatocellular Carcinoma

2009 • 770 citations

IMMUNOBIOLOGY AND PATHOGENESIS OF VIRAL HEPATITIS

2006 • 763 citations

Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer

2005 • 758 citations

B7-H1 Expression on Non-Small Cell Lung Cancer Cells and Its Relationship with Tumor-Infiltrating Lymphocytes and Their PD-1 Expression

2004 • 664 citations

The B7-H1 (PD-L1) T Lymphocyte-Inhibitory Molecule Is Expressed in Breast Cancer Patients with Infiltrating Ductal Carcinoma: Correlation with Important High-Risk Prognostic Factors

2006 • 570 citations

Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion

2006 • 470 citations

Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

2006 • 465 citations

Antiviral Intrahepatic T-Cell Responses Can Be Restored by Blocking Programmed Death-1 Pathway in Chronic Hepatitis B

2009 • 456 citations

Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers

2006 • 447 citations

PD‐L1 (B7‐H1) expression by urothelial carcinoma of the bladder and BCG‐induced granulomata

2007 • 407 citations

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

2006 • 396 citations

B7-H1 Determines Accumulation and Deletion of Intrahepatic CD8+ T Lymphocytes

2004 • 375 citations

PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver

2003 • 373 citations

Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8⁺T Cells Associated with Reversible Immune Dysfunction

2007 • 365 citations

PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis

2006 • 357 citations

Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection

2007 • 281 citations

Regulatory T cells in virus infections

2006 • 254 citations

Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis

2007 • 245 citations

Chronically inflamed livers up-regulate expression of inhibitory B7 family members

2009 • 141 citations

Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma

2011 • 134 citations

Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment

2008 • 125 citations

The regulation of lymphocyte activation by inhibitory receptors

2004 • 98 citations

Programmed cell death 1 ligand 1 and tumor-infiltrating CD8[+] T lymphocytes are prognostic factors of human ovarian cancer

2009 • 87 citations

The balance of immune responses: costimulation verse coinhibition

2005 • 71 citations

Presence of Suppressor HIV-Specific CD8+ T Cells Is Associated with Increased PD-1 Expression on Effector CD8+ T Cells

2008 • 36 citations

879: PD-L1 (B7-H1) Expression by Urothelial Carcinoma of the Bladder and BCG-Induced Granulomata: Associations with Localized Stage Progression

2007 • 32 citations

Interferon-gamma production specific for hepatitis B virus antigen by intrahepatic T lymphocytes in patients with acute and chronic hepatitis B.

1994 • 14 citations

Clonal analysis of intrahepatic T lymphocytes in chronic active hepatitis

1986 • 11 citations

The Chinese classification system compared with TNM staging in prognosis of patients with primary hepatic carcinoma after resection.

2005 • 7 citations

Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection

2007 • 6 citations

Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

2007 • 4 citations