Presence of Suppressor HIV-Specific CD8+ T Cells Is Associated with Increased PD-1 Expression on Effector CD8+ T Cells

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 • 2,521 citations

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

2003 • 1,563 citations

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

2006 • 1,485 citations

Cytotoxic T lymphocytes: all roads lead to death

2002 • 893 citations

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

2006 • 859 citations

Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4

2002 • 800 citations

PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2

2002 • 646 citations

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction

2007 • 502 citations

Generation Ex Vivo of TGF-β-Producing Regulatory T Cells from CD4+CD25− Precursors

2002 • 461 citations

CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status

2004 • 444 citations

Human CD4⁺CD25⁺Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens

2004 • 436 citations

PD-1 and its ligands in T-cell immunity

2007 • 419 citations

Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes

2003 • 388 citations

Human immunodeficiency virus–driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients

2004 • 387 citations

Use of overlapping peptide mixtures as antigens for cytokine flow cytometry

2001 • 358 citations

High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells

2003 • 308 citations

PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors

2007 • 293 citations

CD86 and CD80 Differentially Modulate the Suppressive Function of Human Regulatory T Cells

2004 • 275 citations

Alloantigen specific CD8+CD28− FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity

2004 • 257 citations

Regulatory T cells in virus infections

2006 • 254 citations

Amine reactive dyes: An effective tool to discriminate live and dead cells in polychromatic flow cytometry

2006 • 220 citations

Functions of CD8 T-cell subsets secreting different cytokine patterns

1997 • 210 citations

Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+CD28− T cells and inhibit both T-Cell proliferation and CTL function

2004 • 163 citations

Human Tc1 and Tc2/Tc0 CD8 T-cell clones display distinct cell surface and functional phenotypes

2000 • 153 citations

Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells

2002 • 137 citations

Adherence to Highly Active Antiretroviral Therapy in the Homeless Population in San Francisco: A Prospective Study

2004 • 134 citations

The Functional Profile of Primary Human Antiviral CD8+ T Cell Effector Activity Is Dictated by Cognate Peptide Concentration

2004 • 132 citations

HIV Antigens Can Induce TGF-β1-Producing Immunoregulatory CD8+ T Cells

2002 • 126 citations

Acquisition of anergic and suppressive activities in transforming growth factor- -costimulated CD4+CD25- T cells

2004 • 116 citations

Overlap between molecular markers expressed by naturally occurring CD4+CD25+ regulatory T cells and antigen specific CD4+CD25+ and CD8+CD28− T suppressor cells

2004 • 113 citations

Hepatitis C Virus (HCV)-Specific CD8⁺Cells Produce Transforming Growth Factor β That Can Suppress HCV-Specific T-Cell Responses

2007 • 104 citations

Autoreactive human peripheral blood CD8⁺ T cells with a regulatory phenotype and function

2005 • 93 citations

CD8+ lymphocyte phenotype and cytokine production in long-term non-progressor and in progressor patients with HIV-1 infection

1996 • 87 citations

Interleukin-10 induces the upregulation of the inhibitory receptor ILT4 in monocytes from HIV positive individuals

2003 • 75 citations

Transforming growth factor beta 1 costimulated growth and regulatory function of staphylococcal enterotoxin B-responsive CD8+ T cells.

1995 • 61 citations

Non-antigen specific CD8+ T suppressor lymphocytes

2004 • 58 citations

CD28 co-stimulation regulates the effect of transforming growth factor-β1 on the proliferation of naı̈ve CD4+ T cells

2003 • 48 citations

Coinfection withSchistosoma mansoniIs Associated with Decreased HIV-Specific Cytolysis and Increased IL-10 Production

2005 • 47 citations

HIV-Specific IL-10-Positive CD8+ T Cells Suppress Cytolysis and IL-2 Production by CD8+ T Cells

2007 • 47 citations

HIV-Specific IL-10-Positive CD8+ T Cells Are Increased in Advanced Disease and Are Associated with Decreased HIV-Specific Cytolysis

2006 • 38 citations

Modified anthrax fusion proteins deliver HIV antigens through MHC Class I and II pathways

2005 • 28 citations

HCV‐specific CD27⁻ CD28⁻ memory T cells are depleted in hepatitis C virus and Schistosoma mansoni co‐infection

2003 • 23 citations