Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 • 2,521 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

Immunology of hepatitis B virus and hepatitis C virus infection

2005 • 1,579 citations

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

2003 • 1,500 citations

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

2006 • 1,485 citations

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

2007 • 1,375 citations

Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

2000 • 1,270 citations

Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity

2004 • 1,213 citations

Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection

2001 • 1,183 citations

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

2006 • 859 citations

Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection

2007 • 847 citations

Adaptive immune responses in acute and chronic hepatitis C virus infection

2005 • 747 citations

Impaired Effector Function of Hepatitis C Virus-Specific CD8+ T Cells in Chronic Hepatitis C Virus Infection

2002 • 644 citations

Memory CD8+ T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection

2003 • 636 citations

Evasion of intracellular host defence by hepatitis C virus

2005 • 636 citations

PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion

2006 • 558 citations

Sustained Dysfunction of Antiviral CD8⁺T Lymphocytes after Infection with Hepatitis C Virus

2001 • 496 citations

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

2003 • 486 citations

Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

2006 • 465 citations

Stealth and Cunning: Hepatitis B and Hepatitis C Viruses

2005 • 438 citations

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

2006 • 396 citations

Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8⁺T Cells Associated with Reversible Immune Dysfunction

2007 • 365 citations

PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis

2006 • 357 citations

CD8 Epitope Escape and Reversion in Acute HCV Infection

2004 • 318 citations

High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection

2004 • 301 citations

Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection

2007 • 281 citations

Functional signatures of protective antiviral T‐cell immunity in human virus infections

2006 • 276 citations

Kinetics of the immune response during HBV and HCV infection

2003 • 252 citations

Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C

2005 • 237 citations

PD-1:PD-L1 Interactions Contribute to the Functional Suppression of Virus-Specific CD8+ T Lymphocytes in the Liver

2007 • 233 citations

B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function

2001 • 220 citations

Mutational escape from CD8+ T cell immunity

2005 • 219 citations

The Roles of the New Negative T Cell Costimulatory Pathways in Regulating Autoimmunity

2004 • 208 citations

Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses

2006 • 198 citations

Divergent and convergent evolution after a common-source outbreak of hepatitis C virus

2005 • 187 citations

Liver-Derived CTL in Hepatitis C Virus Infection: Breadth and Specificity of Responses in a Cohort of Persons with Chronic Infection

1998 • 186 citations

Oscillating CD8+ T Cell Effector Functions after Antigen Recognition in the Liver

2005 • 185 citations

Virus-Specific CD8⁺Lymphocytes Share the Same Effector-Memory Phenotype but Exhibit Functional Differences in Acute Hepatitis B and C

2002 • 174 citations

Discordant Role of CD4 T-Cell Response Relative to Neutralizing Antibody and CD8 T-Cell Responses in Acute Hepatitis C

2006 • 160 citations

B7-H1 Up-Regulation on Myeloid Dendritic Cells Significantly Suppresses T Cell Immune Function in Patients with Chronic Hepatitis B

2007 • 121 citations

BASIC-LIVER, PANCREAS, AND BILIARY TRACT Discordant Role of CD4 T-Cell Response Relative to Neutralizing Antibody and CD8 T-Cell Responses in Acute Hepatitis C

2007 • 3 citations