O 6-Alkylguanine-DNA Alkyltransferase

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Human DNA Repair Genes

2001 • 1,451 citations

MGMT: its role in cancer aetiology and cancer therapeutics

2004 • 788 citations

On measures of gametic disequilibrium.

1988 • 727 citations

Genetic studies of the lac repressor

1977 • 610 citations

Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network

2009 • 586 citations

Repair of O6-alkylguanine by alkyltransferases

2000 • 569 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.

2000 • 529 citations

Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase

1995 • 502 citations

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

1990 • 460 citations

Genetic susceptibility to lung cancer: the role of DNA damage and repair.

2003 • 344 citations

DNA binding and nucleotide flipping by the human DNA repair protein AGT

2004 • 289 citations

Cancer Risk and Low-Penetrance Susceptibility Genes in Gene-Environment Interactions

2000 • 275 citations

Targeted Modulation of MGMT: Clinical Implications

2006 • 245 citations

The Prevention of Thymic Lymphomas in Transgenic Mice by Human O ⁶ -Alkylguanine-DNA Alkyltransferase

1993 • 238 citations

Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding

2000 • 219 citations

Ubiquitination-Dependent Proteolysis of O⁶-Methylguanine-DNA Methyltransferase in Human and Murine Tumor Cells following Inactivation with O⁶-Benzylguanine or 1,3-Bis(2-chloroethyl)-1-nitrosourea

1996 • 215 citations

Methylation of Discrete Regions of the O⁶-Methylguanine DNA Methyltransferase (MGMT) CpG Island Is Associated with Heterochromatinization of the MGMT Transcription Start Site and Silencing of the Gene

1997 • 214 citations

Direct Reversal of DNA Alkylation Damage

2006 • 201 citations

O6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung.

1991 • 183 citations

Variability and regulation of O6-alkylguanine-DNA alkyltransferase

2003 • 183 citations

O⁶‐alkylguanine‐DNA alkyltransferase: Role in carcinogenesis and chemotherapy

2002 • 182 citations

DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy

2007 • 170 citations

Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas

2009 • 168 citations

Degradation of the alkylated form of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase

2002 • 162 citations

DNA base repair – recognition and initiation of catalysis

2009 • 157 citations

Recent Advances in Brain Tumor Therapy: Local Intracerebral Drug Delivery by Polymers

2003 • 153 citations

Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

1993 • 152 citations

Recent progress on the Ada response for inducible repair of DNA alkylation damage

2002 • 144 citations

O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis.

1993 • 143 citations

Characterization of the promoter region of the human O⁶-methylguanine-DNA methyltransferase gene

1991 • 142 citations

DNMT3B polymorphisms and risk of primary lung cancer

2004 • 138 citations

Vascular Endothelial Growth Factor Gene Polymorphisms and Risk of Primary Lung Cancer

2005 • 136 citations

Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells.

1992 • 135 citations

Association and Interactions between DNA Repair Gene Polymorphisms and Adult Glioma

2009 • 133 citations

Crystal structure of the human O6-alkylguanine-DNA alkyltransferase

2000 • 131 citations

Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon

1995 • 130 citations

Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice.

1997 • 130 citations

Flipping of alkylated DNA damage bridges base and nucleotide excision repair

2009 • 126 citations

THE CORRELATION AND PROGNOSTIC SIGNIFICANCE OF MGMT PROMOTER METHYLATION AND MGMT PROTEIN IN GLIOBLASTOMAS

2009 • 121 citations

Toxicity, mutagenicity, and mutational spectra of N-ethyl-N-nitrosourea in human cell lines with different DNA repair phenotypes.

1991 • 115 citations

O6-methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary.

1991 • 115 citations

Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases.

1991 • 101 citations

Sequence specificity of guanine alkylation and repair

1988 • 100 citations

Inactivation and degradation of O(6)-alkylguanine-DNA alkyltransferase after reaction with nitric oxide.

2002 • 98 citations

Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine.

1998 • 94 citations

The suicidal DNA repalr methyltransferases of microbes

1992 • 94 citations

High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase

1997 • 93 citations

p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor.

2009 • 90 citations

XPC polymorphisms and lung cancer risk

2005 • 86 citations

Targeted expression of human O(6)-methylguanine-DNA methyltransferase (MGMT) in transgenic mice protects against tumor initiation in two-stage skin carcinogenesis.

1996 • 86 citations

Role of polymorphisms in codons 143 and 160 of the O6-alkylguanine DNA alkyltransferase gene in lung cancer risk.

2000 • 85 citations

Cell-specific differences in O6-alkylguanine DNA repair activity during continuous exposure to carcinogen.

1982 • 84 citations

A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT

2008 • 80 citations

Repair of O⁶-propylguanine and O⁶-butylguanine in DNA by O⁶-alkylguanine-DNA alkyltransferases from rat liver and E. coli

1985 • 80 citations

Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase

2009 • 79 citations

Reduced lung tumorigenesis in human methylguanine DNAmethyltransferase transgenic mice achieved by expression of transgene within the target cell

1999 • 77 citations

DNA-binding Mechanism ofO 6-Alkylguanine-DNA Alkyltransferase

2003 • 75 citations

DNA alterations in cancer : genetic and epigenetic changes

2000 • 73 citations

Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma

2008 • 71 citations

Epigenetic regulation of O6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins

2005 • 70 citations

Specific Recognition of O⁶-Methylguanine in DNA by Active Site Mutants of Human O⁶-Methylguanine-DNA Methyltransferase

1997 • 67 citations

Kinetic Analysis of Steps in the Repair of Damaged DNA by Human O6-Alkylguanine-DNA Alkyltransferase

2005 • 67 citations

DNA Repair in Mammalian Cells

2009 • 66 citations

Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo

2009 • 66 citations

Detection of MGMT Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 MGMT Promoter Single Nucleotide Polymorphism

2009 • 65 citations

O⁶-Alkylguanine-DNA Alkyltransferase: Low pK_a and High Reactivity of Cysteine 145

2003 • 64 citations

Phase II Trial of Gliadel plus O6-Benzylguanine in Adults with Recurrent Glioblastoma Multiforme

2009 • 63 citations

The Repair of the Tobacco Specific Nitrosamine Derived Adduct O⁶-[4-Oxo-4-(3-pyridyl)butyl]guanine by O⁶-Alkylguanine-DNA Alkyltransferase Variants

2004 • 62 citations

Human variants of O6-alkylguanine-DNA alkyltransferase

2007 • 62 citations

Cross-Linking of the DNA Repair Protein O⁶-Alkylguanine DNA Alkyltransferase to DNA in the Presence of Antitumor Nitrogen Mustards

2008 • 61 citations

Cell specific differences in O⁶-methylguanine-DNA methyltransferase activity and removal of O⁶-methylguanine in rat pulmonary cells

1988 • 61 citations

Repair of O6-Benzylguanine by the Escherichia coli Ada and Ogt and the Human O6-Alkylguanine-DNA Alkyltransferases

1997 • 60 citations

Use of antibodies to human O⁶-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O⁶-benzylguanine or N-methyl-N′-nitro-N-nitrosoguanidine

1991 • 59 citations

Genetic polymorphism of human O6-alkylguanine-DNA alkyltransferase

1999 • 59 citations

Methylation of selected CpGs in the humanO6-methylguanine-DNA methyltransferase promoter region as a marker of gene silencing

1999 • 59 citations

Novel O⁶-methylguanine-DNA methyltransferase SNPs: A frequency comparison of patients with familial melanoma and healthy individuals in Sweden

2002 • 57 citations

Quantitative trait locus analysis reveals two intragenic sites that influence O6 -alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells

2005 • 56 citations

Mutagenesis by O⁶-Methyl-, O⁶-Ethyl-, and O⁶-Benzylguanine and O⁴-Methylthymine in Human Cells: Effects of O⁶-Alkylguanine-DNA Alkyltransferase and Mismatch Repair

2001 • 56 citations

Cross-Linking of the Human DNA Repair Protein O⁶-Alkylguanine DNA Alkyltransferase to DNA in the Presence of 1,2,3,4-Diepoxybutane

2006 • 56 citations

Function of Domains of Human O⁶-Alkylguanine-DNA Alkyltransferase

2005 • 56 citations

Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O ⁶ - methylguanine-DNA methyltransferase

2001 • 55 citations

Organization and expression of the human gene for O6-methylguanine-DNA methyltransferase

1993 • 53 citations

2-Amino-O⁴-benzylpteridine Derivatives: Potent Inactivators of O⁶-Alkylguanine-DNA Alkyltransferase

2004 • 53 citations

O ⁶ -methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo

2009 • 52 citations

Mammalian DNA repair methyltransferases shield O4MeT from nucleotide excision repair

1997 • 52 citations

Paradoxical Enhancement of the Toxicity of 1,2-Dibromoethane byO 6-Alkylguanine-DNA Alkyltransferase

2002 • 50 citations

Repair of O⁶-G-Alkyl-O⁶-G Interstrand Cross-Links by Human O⁶-Alkylguanine-DNA Alkyltransferase

2008 • 48 citations

Characterization of a Mutagenic DNA Adduct Formed from 1,2-Dibromoethane by O6-Alkylguanine-DNA Alkyltransferase

2004 • 48 citations

O6-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib

2009 • 47 citations

Alkyltransferase-like proteins

2007 • 47 citations

The alkyltransferase-like ybaZ gene product enhances nucleotide excision repair of O6-alkylguanine adducts in E. coli

2009 • 46 citations

Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins

2008 • 46 citations

Activation of bis-Electrophiles to Mutagenic Conjugates by Human O⁶-Alkylguanine-DNA Alkyltransferase

2004 • 45 citations

Interactions of Human O6-Alkylguanine-DNA Alkyltransferase (AGT) with Short Single-stranded DNAs

2006 • 44 citations

The DNA repair protein O6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineoplastic chloroethylnitrosourea.

1997 • 44 citations

MGMT analysis at DNA, RNA and protein levels in glioblastoma tissue.

2009 • 43 citations

Cytoplasmic sequestration of an O ⁶ -methylguanine-DNA methyltransferase enhancer binding protein in DNA repair-deficient human cells

1997 • 41 citations

Differences in the Rate of Repair of O⁶-Alkylguanines in Different Sequence Contexts by O⁶-Alkylguanine-DNA Alkyltransferase

2007 • 41 citations

Repair of O6-methylguanine and O4-methylthymidine in F344 rat liver following treatment with 1,2-dimethylhydrazine and O6-benzylguanine.

1993 • 40 citations

A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O ⁶ -alkylguanine-DNA alkyltransferase and endonuclease V activities

2005 • 39 citations

Inhibition of human O6-methylguanine-DNA methyltransferase by 5-methylcytosine.

1994 • 38 citations

Density functional theory study of the reaction mechanism of the DNA repairing enzyme alkylguanine alkyltransferase

2008 • 37 citations

Organization and expression of the human gene for O^6-methylguanine-DNA methyltransferase

1993 • 36 citations

Long-time expression of DNA repair enzymes MGMT and APE in human peripheral blood mononuclear cells

2001 • 36 citations

Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N′-nitro-N-nitrosoguanidine

1999 • 35 citations

An O6-methylguanine-DNA Methyltransferase-like Protein from Thermus thermophilus Interacts with a Nucleotide Excision Repair Protein

2008 • 35 citations

Comparative efficiency of forming m4T.cntdot.G versus m4T.cntdot.A base pairs at a unique site by use of Escherichia coli DNA polymerase I (Klenow fragment) and Drosophila melanogaster polymerase .alpha.-primase complex

1990 • 35 citations

DNA Sequence Context Affects Repair of the Tobacco-Specific Adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by Human O6-Alkylguanine-DNA Alkyltransferases

2006 • 34 citations

Repair of O4-Alkylthymine by O6-Alkylguanine-DNA Alkyltransferases

2009 • 33 citations

The role of human O6-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli

2000 • 32 citations

Overexpression of human O6-alkylguanine DNA alkyltransferase (AGT) prevents MNU induced lymphomas in heterozygous p53 deficient mice

2001 • 31 citations

Repair of DNA lesions introduced by N-nitroso compounds

1986 • 30 citations

Mouse methyltransferase for repair of O⁶-methylguanine and O⁴-methylthymine in DNA

1995 • 30 citations

β-Glucuronidase-Cleavable Prodrugs of O⁶-Benzylguanine and O⁶-Benzyl-2‘-deoxyguanosine

2004 • 29 citations

Topologies of Complexes Containing O6-Alkylguanine–DNA Alkyltransferase and DNA

2009 • 29 citations

Interactions of Human O⁶-Alkylguanine-DNA Alkyltransferase (AGT) with Short Double-Stranded DNAs

2008 • 29 citations

Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA

1999 • 29 citations

Novel DNA repair alkyltransferase from Caenorhabditis elegans

2001 • 28 citations

ogt alkyltransferase enhances dibromoalkane mutagenicity in excision repair–deficient escherichia coli K‐12

1995 • 28 citations

Reciprocal Relationship between O6-Methylguanine-DNA Methyltransferase P140K Expression Level and Chemoprotection of Hematopoietic Stem Cells

2008 • 27 citations

Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer.

1999 • 26 citations

Promoter methylation of O6-methylguanine-DNA-methyltransferase in lung cancer is regulated by p53

2008 • 26 citations

O ⁶-Alkylguanine-DNA Alkyltransferase Has Opposing Effects in Modulating the Genotoxicity of Dibromomethane and Bromomethyl Acetate

2004 • 25 citations

Using the Bias from Flow to Elucidate Single DNA Repair Protein Sliding and Interactions with DNA

2009 • 25 citations

O6-Methylguanine-DNA methyltransferase hypermethylation modulated by 17beta-estradiol in lung cancer cells.

2009 • 24 citations

Suppression of HLA expression by lentivirus-mediated gene transfer of siRNA cassettes and in vivo chemoselection to enhance hematopoietic stem cell transplantation

2008 • 23 citations

Pharmacokinetics of temozolomide administered in combination with O6-benzylguanine in children and adolescents with refractory solid tumors

2009 • 23 citations

Alkyltransferase-Mediated Toxicity of 1,3-Butadiene Diepoxide

2008 • 23 citations

Expression in mammalian cells of the Escherichia coli O6 alkylguanine-DNA-alkyltransferase gene ogt reduces the toxicity of alkylnitrosoureas

1993 • 21 citations

Inactivation of O⁶-Alkylguanine-DNA Alkyltransferase by Folate Esters of O⁶-Benzyl-2‘-deoxyguanosine and of O⁶-[4-(Hydroxymethyl)benzyl]guanine

2007 • 21 citations

Protection against Malignant Progression of Spontaneously Developing Liver Tumors in Transgenic Mice Expressing O⁶‐Methylguanine‐DNA Methyltransferase

2000 • 21 citations

Kinetics of O⁶-Methyl-2‘-deoxyguanosine Repair by O⁶-Alkylguanine DNA Alkyltransferase within K-ras Gene-Derived DNA Sequences

2006 • 19 citations

DNA Repair in Cancer Therapy

2004 • 18 citations

Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase

2007 • 18 citations

Cytosine Methylation Effects on the Repair of O6-Methylguanines within CG Dinucleotides

2009 • 18 citations

Degradation of BRCA2 in Alkyltransferase-Mediated DNA Repair and Its Clinical Implications

2008 • 18 citations

The L84F polymorphism in the O 6 -Methylguanine-DNA-Methyltransferase (MGMT) gene is associated with increased hypoxanthine phosphoribosyltransferase (HPRT) mutant frequency in lymphocytes of tobacco smokers

2007 • 17 citations

Prolonged Cell Cycle Response of HeLa Cells to Low-Level Alkylation Exposure

2009 • 16 citations

Repair of O6-methylguanine to guanine by cysteine in the absence and presence of histidine and by cysteine thiolate anion: a quantum chemical study

2009 • 14 citations

Large-Scale Evaluation of Genetic Variants in Candidate Genes for Colorectal Cancer Risk in the Nurses' Health Study and the Health Professionals' Follow-up Study

2008 • 14 citations

The alleles of the DNA repair gene O6-alkylguanine-DNA alkyltransferase are expressed at different levels in normal human lung tissue

2003 • 14 citations

In situ hybridization of human kidney tissue reveals cell-type-specific expression of the O⁶methylguanine-DNA methyltransferase gene

1992 • 14 citations

The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity

2008 • 13 citations

DNA Repair in Cancer Therapy

2004 • 13 citations

Effect ofO⁶-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins

2009 • 11 citations

Bone Marrow-Derived Cells Exhibiting Lung Epithelial Cell Characteristics Are Enriched In Vivo Using Methylguanine DNA Methyltransferase-Mediated Drug Resistance

2008 • 11 citations

Investigation of the specificity of O6-alkylguanine-DNA-alkyltransferase

1988 • 10 citations

O6-Alkylguanine DNA alkyltransferase activity in student embalmers

1997 • 9 citations

Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum

2004 • 7 citations

Structural Biology of DNA Damage and Repair

2010 • 5 citations

Apparent Directional Scanning for DNA Repair

2007 • 5 citations

Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure

2008 • 4 citations

Overcoming Resistance to Alkylating Agents by Inhibitors of O 6-Alkylguanine-DNA Alkyltransferase

2004 • 2 citations