Comparative efficiency of forming m4T.cntdot.G versus m4T.cntdot.A base pairs at a unique site by use of Escherichia coli DNA polymerase I (Klenow fragment) and Drosophila melanogaster polymerase .alpha.-primase complex

Polymer support oligonucleotide synthesis XVIII^1.2): use ofβ-cyanoethyi-N,N-dialkylamino-/N-morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product

1984 • 840 citations

DNA polymerase insertion fidelity. Gel assay for site-specific kinetics.

1987 • 332 citations

Nearest Neighbor Influences on DNA Polymerase Insertion Fidelity

1989 • 247 citations

Nucleotide insertion kinetics opposite abasic lesions in DNA.

1987 • 209 citations

Base pairing and mutagenesis: observation of a protonated base pair between 2-aminopurine and cytosine in an oligonucleotide by proton NMR.

1986 • 202 citations

Construction of a plasmid that overproduces the large proteolytic fragment (Klenow fragment) of DNA polymerase I of Escherichia coli.

1983 • 168 citations

O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine, accumulates in hepatocyte DNA of rats exposed continuously to diethylnitrosamine.

1984 • 164 citations

Effects of methylation on the stability of nucleic acid conformations. Studies at the polymer level.

1978 • 150 citations

Mutagenic potential of O4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis.

1986 • 143 citations

Isolation of an intact DNA polymerase-primase from embryos of Drosophila melanogaster.

1983 • 132 citations

Differential extension of 3′ mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-α

1989 • 129 citations

Effect of 3' flanking neighbors on kinetics of pairing of dCTP or dTTP opposite O6-methylguanine in a defined primed oligonucleotide when Escherichia coli DNA polymerase I is used.

1989 • 112 citations

Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.

1986 • 107 citations

Synthesis and properties of oligonucleotides containing 2′-deoxynebularine and 2′-deoxyxanthosine

1986 • 104 citations

Repair of O-alkylpyrimidines in mammalian cells: a present consensus.

1988 • 104 citations

Recent studies of the fidelity of DNA synthesis

1988 • 98 citations

Differential repair of O⁴-alkylthymidine following exposure to methylating and ethylating hepatocarcinogens

1985 • 86 citations

Base pair mismatches and carcinogen-modified bases in DNA: an NMR study of G.cntdot.T and G.cntdot.O4meT pairing in dodecanucleotide duplexes

1988 • 78 citations

Tissue-dependent enzyme-mediated repair or removal of O-ethyl pyrimidines and ethyl purines in carcinogen-treated rats

1981 • 74 citations

O²- and O⁴-Alkyl pyrimidine nucleosides: stability of the glycosyl bond and of the alkyl group as a function of pH

1978 • 74 citations

Repair of O⁶-methylguanine, O⁶-ethylguanine, O⁶-isopropylguanine, and O⁴-methylthymine in synthetic oligodeoxynucleotides by Escherichia coli ada gene O⁶-alkylguanine-DNA-alkyltransferase

1989 • 71 citations

Ionized and wobble base-pairing for bromouracil-guanine in equilibrium under physiological conditions

1989 • 70 citations

O4-Methyl, -ethyl, or -isopropyl substituents on thymidine in poly(dA-dT) all lead to transitions upon replication.

1986 • 66 citations

On the molecular basis of transition mutations: frequencies of forming 2-aminopurine.cytosine and adenine.cytosine base mispairs in vitro.

1981 • 63 citations

Escherichia coli polymerase I can use O2-methyldeoxythymidine or O4-methyldeoxythymidine in place of deoxythymidine in primed poly(dA-dT).poly(dA-dT) synthesis.

1983 • 61 citations

Preparation and template activities of polynucleotides containing O2- and O4-alkyluridine.

1978 • 61 citations

Correlation of O⁴-ethyldeoxythymidine accumulation, hepatic initiation and hepatocellular carcinoma induction in rats continuously administered diethylnitrosamine

1986 • 55 citations

Comparison of the relative mutagenicities of O-alkylthymines site-specifically incorporated into phi X174 DNA.

1987 • 55 citations

Synthesis and characterization of oligodeoxynucleotides containing 4-O-methylthymine

1987 • 54 citations

Assessment of mutagenic efficiency of two carcinogen-modified nucleosides, 1,N⁶-ethenodeoxyadenosine and O⁴-methyldeoxythymidine, using polymerases of varying fidelity

1984 • 53 citations

The biochemical basis of 5-bromouracil-induced mutagenesis. Heteroduplex base mispairs involving bromouracil in G x C----A x T and A x T----G x C mutational pathways.

1984 • 52 citations

Reaction of diazoalkanes with 1-substituted 2, 4-dioxopyrimidines. Formation of O2, N-3 and O4-alkyl products.

1976 • 52 citations

Specifically alkylated DNA fragments. Synthesis and Physical Characterization of D[cGC(o²Me)GCG]and d[cGT(O⁶Me) GCG]

1983 • 51 citations

Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli

1984 • 44 citations

Specificity of proofreading by the 3‘—-5‘ exonuclease of the DNA polymerase-primase of Drosophila melanogaster.

1988 • 42 citations

On the molecular basis of transition mutations. Frequency of forming 2-aminopurine-cytosine base mispairs in the G X C—-A X T mutational pathway by T4 DNA polymerase in vitro.

1984 • 38 citations

NMR studies on an oligodeoxynucleotide containing 2-aminopurine opposite adenine

1987 • 30 citations

Deoxyhexanucleotide containing a vinyl chloride induced DNA lesion, 1,N6-ethenoadenine: synthesis, physical characterization, and incorporation into a duplex bacteriophage M13 genome as part of an amber codon

1987 • 28 citations

Solid-phase synthesis and side reactions of oligonucleotides containing O-alkylthymine residues

1989 • 26 citations

Comparison of polymerase insertion and extension kinetics of a series of O2-alkyldeoxythymidine triphosphates and O4-methyldeoxythymidine triphosphate

1989 • 25 citations

A fidelity assay using "dideoxy" DNA sequencing: a measurement of sequence dependence and frequency of forming 5-bromouracil X guanine base mispairs.

1985 • 23 citations

A kinetic and nuclear magnetic resonance study of methylated pyrimidine nucleosides

1983 • 20 citations

Use of a dodecadeoxynucleotide to study repair of the O4-methylthymine lesion

1988 • 20 citations

Enzymatic elimination of O⁶‐ethylguanine from the DNA of ethylnitrosourea‐exposed normal and malignant rat brain cells grown under cell culture versus in vivo conditions

1988 • 12 citations

O⁴-Methyldeoxythymidine replacing deoxythymidine in poly[d(A—T)] renders the polymer resistant to the 3′ → 5′ exonuclease activity of the Klenow and T₄DNA polymerases

1986 • 6 citations