Prolonged Cell Cycle Response of HeLa Cells to Low-Level Alkylation Exposure

A simple technique for quantitation of low levels of DNA damage in individual cells

1988 • 10,537 citations

DNA MISMATCH REPAIR

2005 • 1,296 citations

The multifaceted mismatch-repair system

2006 • 1,264 citations

Cell death by mitotic catastrophe: a molecular definition

2004 • 1,201 citations

DNA Mismatch Repair: Functions and Mechanisms

2005 • 851 citations

MGMT: its role in cancer aetiology and cancer therapeutics

2004 • 788 citations

Temozolomide and treatment of malignant glioma.

2000 • 695 citations

Alkylation damage in DNA and RNA—repair mechanisms and medical significance

2004 • 613 citations

DNA Mismatch Repair: Molecular Mechanisms and Biological Function

2003 • 491 citations

The Molecular Basis of Cancer

1985 • 389 citations

Mismatch repair and DNA damage signalling

2004 • 388 citations

Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint.

1995 • 362 citations

DNA double-strand breaks measured in individual cells subjected to gel electrophoresis.

1991 • 330 citations

Repair of alkylated DNA: Recent advances

2006 • 316 citations

Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy

2004 • 289 citations

ATR Kinase Activation Mediated by MutSα and MutLα in Response to Cytotoxic O6-Methylguanine Adducts

2006 • 280 citations

Mismatch repair-dependent G₂ checkpoint induced by low doses of S_N1 type methylating agents requires the ATR kinase

2004 • 240 citations

The Role of Base Excision Repair in the Sensitivity and Resistance to Temozolomide-Mediated Cell Death

2005 • 236 citations

An Msh2 Point Mutation Uncouples DNA Mismatch Repair and Apoptosis

2004 • 186 citations

An evaluation of the double thymidine block for synchronizing mammalian cells at the G1-S border*1

1971 • 181 citations

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

2003 • 177 citations

Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA

2007 • 168 citations

Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility

2004 • 160 citations

RPA Phosphorylation in Mitosis Alters DNA Binding and Protein−Protein Interactions

2003 • 119 citations

Genomic instability and tolerance to alkylating agents.

1996 • 106 citations

Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting

1997 • 95 citations

Apoptotic Signaling in Response to a Single Type of DNA Lesion, O6-Methylguanine

2004 • 94 citations

Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines

2009 • 93 citations

Mismatch Repair-dependent Iterative Excision at Irreparable O6-Methylguanine Lesions in Human Nuclear Extracts

2006 • 91 citations

Recent Approaches to Improve the Antitumor Efficacy of Temozolomide

2008 • 84 citations

Human mismatch repair, drug-induced DNA damage, and secondary cancer

2003 • 83 citations

Phosphohistone H3 labelling for histoprognostic grading of breast adenocarcinomas and computer-assisted determination of mitotic index

2006 • 67 citations

The cell cycle and DNA mismatch repair

2006 • 62 citations

Mismatch G-T binding activity and MSH2 expression is quantitatively related to sensitivity of cells to methylating agents

1998 • 48 citations

Chromosome damage and progression into and through mitosis in vertebrates

2004 • 42 citations

Mismatch repair deficient human cells: spontaneous and MNNG-induced mutational spectra in the HPRT gene

2000 • 40 citations

Rapid induction of chromatin-associated DNA mismatch repair proteins after MNNG treatment

2008 • 39 citations

A single cycle of treatment with temozolomide, alone or combined with O6-benzylguanine, induces strong chemoresistance in melanoma cell clones in vitro: role of O6-methylguanine-DNA methyltransferase and the mismatch repair system

2006 • 34 citations

DNA mismatch repair efficiency and fidelity are elevated during DNA synthesis in human cells

2008 • 24 citations

DNA DOUBLE-STRAND BREAKS DETECTED IN INDIVIDUAL CELLS

1991 • 14 citations