Differential rates of conversion of rat proinsulins I and II. Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin II

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

BIOSYNTHETIC PROTEIN TRANSPORT AND SORTING BY THE ENDOPLASMIC RETICULUM AND GOLGI

1987 • 985 citations

Post-Translational Proteolysis in Polypeptide Hormone Biosynthesis

1982 • 590 citations

The structure and evolution of the two nonallelic rat preproinsulin genes

1979 • 500 citations

POLYPROTEIN GENE EXPRESSION: Generation of Diversity of Neuroendocrine Peptides

1984 • 497 citations

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases

1988 • 403 citations

Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles.

1986 • 331 citations

ISOLATION OF RAT PANCREATIC ISLETS BY DUCTAL INJECTION OF COLLAGENASE1

1986 • 256 citations

Secretion and processing of insulin precursors in yeast.

1986 • 227 citations

Studies on the Conversion of Proinsulin to Insulin

1971 • 206 citations

The insulin secretory granule

1989 • 188 citations

Precursors for peptide hormones share common secondary structures forming features at the proteolytic processing sites

1986 • 183 citations

The insulin factory: a tour of the plant surroundings and a visit to the assembly line

1985 • 172 citations

INSULIN BIOSYNTHESIS IN THE RAT: DEMONSTRATION OF TWO PROINSULINS

1969 • 155 citations

Stimulation of insulin secretion reveals heterogeneity of pancreatic B cells in vivo.

1987 • 155 citations

The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing

1987 • 143 citations

NMR and photo-CIDNP studies of human proinsulin and prohormone processing intermediates with application to endopeptidase recognition

1990 • 99 citations

Endopeptidases and prohormone processing

1990 • 91 citations

Differences in aggregation properties and levels of the neural cell adhesion molecule (NCAM) between islet cell types

1990 • 90 citations

Processing of pro-hormone precursor proteins

1989 • 89 citations

Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump.

1987 • 72 citations

Proinsulin radioimmunoassay in the evaluation of insulinomas and familial hyperproinsulinemia

1986 • 67 citations

Proton-translocating Mg2+-dependent ATPase activity in insulin-secretory granules

1982 • 67 citations

Processing Endoprotease Recognizes a Structural Feature at the Cleavage Site of Peptide Prohormones

1989 • 62 citations

Familial hyperproinsulinemia. Two cohorts secreting indistinguishable type II intermediates of proinsulin conversion.

1984 • 59 citations

Site-specific mutagenesis identifies amino acid residues critical in prohormone processing.

1989 • 54 citations

Inhibition of islet prohormone to hormone conversion by incorporation of arginine and lysine analogs.

1981 • 51 citations

Proinsulin endopeptidase substrate specificities defined by site-directed mutagenesis of proinsulin

1989 • 50 citations

Deletion of a highly conserved tetrapeptide sequence of the proinsulin connecting peptide (C-peptide) inhibits proinsulin to insulin conversion by transfected pituitary corticotroph (AtT20) cells

1989 • 41 citations

High-performance liquid chromatography (HPLC): A rapid, flexible and sensitive method for separating islet proinsulin and insulin

1986 • 30 citations

Selective Expression and Developmental Regulation of the Ancestral Rat Insulin II Gene in Fetal Liver

1990 • 30 citations

Inhibition of proinsulin to insulin conversion in rat islets using arginine and lysine analogs. Lack of effect on rate of release of modified products.

1982 • 30 citations

Reversed-phase high-performance liquid chromatographic analyses of insulin biosynthesis in isolated rat and mouse islets

1989 • 26 citations

Differential kinetics of rat insulin I and II processing in rat islets of Langerhans

1987 • 17 citations

Oxidation of rat insulin II, but not I, leads to anomalous elution profiles upon HPLC analysis of insulin‐related peptides

1988 • 17 citations

Selective Expression of the Insulin I Gene in Rat Insulinoma-Derived Cell Lines

1990 • 12 citations