Airborne nitric oxide: Inflammatory marker and aerocrine messenger in man

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome

1993 • 1,811 citations

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

1981 • 1,624 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Increased nitric oxide in exhaled air of asthmatic patients

1994 • 1,462 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

Nitric oxide activates cyclooxygenase enzymes.

1993 • 1,416 citations

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

1994 • 1,348 citations

Targeted disruption of the neuronal nitric oxide synthase gene

1993 • 1,300 citations

Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide

1990 • 1,284 citations

Increased amount of nitric oxide in exhaled air of asthmatics

1993 • 1,252 citations

A Human Syndrome Caused by Immotile Cilia

1976 • 1,235 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction.

1991 • 1,134 citations

Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans

1991 • 960 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Measurement of nitric oxide in biological models

1993 • 925 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

Inflammation, immunoregulation, and inducible nitric oxide synthase

1993 • 877 citations

Physiology of the Gastrointestinal Tract

1981 • 859 citations

Induction of nitric oxide synthase in asthma

1993 • 852 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Enzyme-independent formation of nitric oxide in biological tissues

1995 • 783 citations

Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate

1995 • 698 citations

Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells.

1994 • 595 citations

Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry

1992 • 588 citations

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

1993 • 552 citations

Single-breath nitric oxide measurements in asthmatic patients and smokers

1994 • 498 citations

Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication.

1993 • 470 citations

Nitric oxide synthase activity in ulcerative colitis and Crohn's disease

1993 • 468 citations

Amelioration of chronic ileitis by nitric oxide synthase inhibition.

1993 • 416 citations

Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections

1995 • 413 citations

Nitric Oxide Activates Metalloprotease Enzymes in Articular Cartilage

1995 • 410 citations

Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat

1990 • 389 citations

The effect of nitrate intake on nitrite formation in human saliva

1976 • 388 citations

The kinetics and equilibria of the reactions of nitric oxide with sheep haemoglobin

1957 • 385 citations

Modulation of Airway Epithelial Cell Ciliary Beat Frequency by Nitric Oxide

1993 • 373 citations

Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease.

1995 • 363 citations

Expired nitric oxide levels during treatment of acute asthma.

1995 • 353 citations

Increased nitric oxide synthesis in ulcerative colitis

1993 • 347 citations

Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide.

1995 • 329 citations

Modulation of adjuvant arthritis by endogenous nitric oxide

1993 • 316 citations

Elevated levels of exhaled nitric oxide in bronchiectasis.

1995 • 308 citations

Inhibitors of endogenous nitrosation mechanisms and implications in human cancer prevention

1988 • 297 citations

Patients with achalasia lack nitric oxide synthase in the gastro‐oesophageal junction

1993 • 295 citations

Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract.

1996 • 284 citations

Prolonged Inhalation of Low Concentrations of Nitric Oxide in Patients with Severe Adult Respiratory Distress Syndrome

1994 • 282 citations

Reaction of No With O₂⁻. Implications for the Action of Endothelium-Derived Relaxing Factor (EDRF)

1990 • 273 citations

The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen.

1995 • 270 citations

Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx

1994 • 258 citations

Efficacy of Inhaled Nitric Oxide in Patients With Severe ARDS

1995 • 258 citations

Endothelial nitric oxide synthase is expressed in cultured human bronchiolar epithelium.

1994 • 216 citations

Endogenous Nitric Oxide in Single Exhalations and the Change during Exercise

1993 • 214 citations

Nitric oxide, a biological effector

1991 • 203 citations

Nitric oxide synthase induction and intestinal epithelial cell viability in rats

1993 • 196 citations

Inhaled nitric oxide in acute respiratory failure: Dose-response curves

1994 • 190 citations

Effects of nitric oxide and nitrogen dioxide on bacterial growth

1983 • 182 citations

Identification of the subcellular site for nitroglycerin metabolism to nitric oxide in bovine coronary smooth muscle cells.

1990 • 177 citations

Blood nitrates and infantile methemoglobinemia

1982 • 175 citations

Changes in urinary cytokines and soluble intercellular adhesion molecule-1 (ICAM-1) in bladder cancer patients after Bacillus Calmette—Guérin (BCG) immunotherapy

1995 • 171 citations

Arginine-Supplemented Diets Improve Survival in Gut-Derived Sepsis and Peritonitis by Modulating Bacterial Clearance The Role of Nitric Oxide

1993 • 170 citations

Nitric oxide donors increase mucus gel thickness in rat stomach

1992 • 167 citations

Measurement of exhaled nitric oxide in man.

1993 • 157 citations

[Nitrogen oxides in tobacco smoke].

1972 • 157 citations

Early loss of the tyrosyl radical in ribonucleotide reductase of adenocarcinoma cells producing nitric oxide

1992 • 144 citations

Expression of nitric oxide synthase in the human nasal mucosa.

1996 • 137 citations

Time‐dependent enhancement or inhibition of endotoxin‐induced vascular injury in rat intestine by nitric oxide synthase inhibitors

1994 • 137 citations

Protective effect of S-nitroso-N-acetyl-penicillamine in endotoxin-induced acute intestinal damage in the rat

1990 • 133 citations

Nitric Oxide Inhibits Numerous Features of Mast Cell–Induced Inflammation

1996 • 119 citations

Inhibitors of nitric oxide synthetase prevent castor‐oil‐induced diarrhoea in the rat

1993 • 114 citations

Effect of endothelium-derived relaxing factor on the gastric lesion induced by HCl in rats.

1990 • 109 citations

Multifunctional role of nitric oxide in inflammation

1994 • 105 citations

Heme-Dependent Activation of Guanylate Cyclase by Nitric Oxide: A Novel Signal Transduction Mechanism

1991 • 103 citations

Nitric Oxide Is Present in Exhaled Breath in Humans: Direct GC-MS Confirmation

1994 • 94 citations

Non‐adrenergic, non‐cholinergic nerve‐mediated relaxation of rabbit urethra is caused by nitric oxide

1991 • 89 citations

Nitric oxide synthase activity in the human urogenital tract

1994 • 87 citations

Nitric oxide, produced in the upper airways, may act in an ‘aerocrine’ fashion to enhance pulmonary oxygen uptake in humans

1995 • 81 citations

Pulmonary effects of endogenous and exogenous nitric oxide in the pig: relation to cigarette smoke inhalation

1993 • 66 citations

Methods for collecting individual components of mixed saliva: the relevance to clinical pharmacology.

1976 • 61 citations

Biosynthesis of blood group I and i antigens in rat tissues. Identification of a novel beta 1-6-N-acetylglucosaminyltransferase.

1992 • 58 citations

Nitric oxide inhalation selectively attenuates pulmonary hypertension and arterial hypoxia in porcine endotoxin shock

1991 • 53 citations

Nitric oxide (NO) in expired air at rest and during exercise

1994 • 48 citations

Pathophysiology of the ciliary motility syndromes.

1983 • 40 citations

Nitric oxide: Delivery, measurement, and clinical application

1995 • 38 citations

Nitric oxide synthase immunoreactive neurons in the rat kidney

1993 • 25 citations

Molecular Genetic Analysis of the Duplication of Human Inducible Nitric Oxide Synthase (NOS2) Sequences

1995 • 21 citations

Modulation of smooth muscle activity by nitric oxide in the human upper urinary tract

1995 • 15 citations

Aerosol, Humidity and Oxygenation

1991 • 5 citations