Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication.

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Nitric oxide, a novel neuronal messenger

1992 • 1,864 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

1981 • 1,624 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Infections with Herpes Simplex Viruses

1986 • 774 citations

Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine.

1990 • 751 citations

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

1986 • 726 citations

Mapping of Herpes Simplex Virus-1 Neurovirulence to γ ₁ 34.5, a Gene Nonessential for Growth in Culture

1990 • 705 citations

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

1992 • 616 citations

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

1991 • 600 citations

Signal transduction mechanisms involving nitric oxide

1991 • 538 citations

Risk Factors for the Sexual Transmission of Genital Herpes

1992 • 476 citations

Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs ¹

1991 • 461 citations

Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway.

1991 • 384 citations

Practical flow cytometry

1989 • 374 citations

Infections with Herpes Simplex Viruses

1986 • 371 citations

A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency

1989 • 341 citations

Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates

1991 • 340 citations

Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

1988 • 337 citations

Inactivation of ribonucleotide reductase by nitric oxide

1991 • 331 citations

Localization of NADPH‐diaphorase‐containing neurons in sensory ganglia of the rat

1991 • 330 citations

Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.

1989 • 320 citations

Marked increase in nitric oxide synthase mRNA in rat dorsal root ganglia after peripheral axotomy: in situ hybridization and functional studies.

1992 • 289 citations

An unusually stable thionitrite from N-acetyl-D,L-penicillamine; X-ray crystal and molecular structure of 2-(acetylamino)-2-carboxy-1,1-dimethylethyl thionitrite

1978 • 281 citations

Human herpesviruses: a consideration of the latent state

1989 • 279 citations

Overproduction of Nitric Oxide in Cytokine-Mediated and Septic Shock

1992 • 271 citations

Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency

1992 • 234 citations

Factor(s) present in herpes simplex virus type 1-infected cells can compensate for the loss of the large subunit of the viral ribonucleotide reductase: characterization of an ICP6 deletion mutant

1988 • 226 citations

A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells

1989 • 225 citations

Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants

1990 • 182 citations

Inhibition of Cryptococcus neoformans replication by nitrogen oxides supports the role of these molecules as effectors of macrophage-mediated cytostasis

1991 • 179 citations

The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency.

1991 • 144 citations

Human gamma interferon and tumor necrosis factor exert a synergistic blockade on the replication of herpes simplex virus

1989 • 126 citations

The Biology Of Cachectin/TNF: A Primary Mediator Of The Host Response

1989 • 115 citations

A cellular function can enhance gene expression and plating efficiency of a mutant defective in the gene for ICP0, a transactivating protein of herpes simplex virus type 1

1991 • 114 citations

Human herpesviruses: a consideration of the latent state.

1989 • 101 citations

Latency-associated transcript but not reactivatable virus is present in sensory ganglion neurons after inoculation of thymidine kinase-negative mutants of herpes simplex virus type 1

1989 • 87 citations

The Role of Arginine in the Replication of Herpes Simplex Virus

1967 • 85 citations

Role as Antibody-Dependent Cellular Cytotoxicity in Defense Against Herpes Simplex Virus Infections

1990 • 62 citations

Rescue of a herpes simplex virus type 1 neurovirulence function with a cloned DNA fragment

1985 • 61 citations

Nitric oxide: A novel neuronal messenger

1991 • 52 citations

Role of viral ribonucleotide reductase in the increase of dTTP pool size in herpes simplex virus-infected Vero cells

1991 • 32 citations

CAS 936, a Novel Sydnonimine with Direct Vasodilating and Nitric Oxide-Donating Properties

1991 • 29 citations

Interleukin-2 Protects Neonatal Mice from Lethal Herpes Simplex Virus Infection: A Macrophage-Mediated, Interferon-Induced Mechanism

1989 • 26 citations

Protection against murine neonatal herpes simplex virus infection by lymphokine-treated human leukocytes.

1990 • 24 citations

Cyclic nucleotide modulation of herpes simplex virus latency and reactivation.

1989 • 10 citations

Enhancement of Human Neonatal Natural Killer Cytotoxicity to Herpes Simplex Virus with Use of Recombinant Human Interferons: Lack of Neonatal Response to γ Interferon

1986 • 10 citations

Human newborn natural killer cell responses to activation by monoclonal antibodies. Effect of culture with herpes simplex virus.

1989 • 9 citations