Most-Cited Papers of All Time

Ranked by total citations across every field in the SciSciNet-V2 corpus. Showing ranks 1–50 of 5,000.

1. 1.PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry · 1951319,299 citations
2. 2.R: A language and environment for statistical computing.MSOR Connections · 2014297,811 citations
3. 3.Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature · 1970253,849 citations
4. 4.A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry · 1976225,752 citations
5. 5.A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry · 1976200,127 citations
6. 6.Deep Residual Learning for Image Recognition2016180,422 citations
7. 7.Generalized Gradient Approximation Made SimplePhysical Review Letters · 1996177,386 citations
8. 8.Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods · 2001156,143 citations
9. 9.Using thematic analysis in psychologyQualitative Research in Psychology · 2006133,580 citations
10. 10.Molecular Cloning: A Laboratory Manual2001133,517 citations
11. 11.Efficient iterative schemes forab initiototal-energy calculations using a plane-wave basis setPhysical review. B, Condensed matter · 1996100,156 citations
12. 12.UntitledMachine Learning · 200198,485 citations
13. 13.Density-functional thermochemistry. III. The role of exact exchangeThe Journal of Chemical Physics · 199395,597 citations
14. 14.Diagnostic and Statistical Manual of Mental Disorders201395,283 citations
15. 15.Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple TestingJournal of the Royal Statistical Society Series B (Statistical Methodology) · 199593,704 citations
16. 16.Development of the Colle-Salvetti correlation-energy formula into a functional of the electron densityPhysical review. B, Condensed matter · 198893,162 citations
17. 17.Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternativesStructural Equation Modeling A Multidisciplinary Journal · 199988,178 citations
18. 18.Basic local alignment search toolJournal of Molecular Biology · 199087,358 citations
19. 19.Molecular cloning: A laboratory manualAnalytical Biochemistry · 199085,659 citations
20. 20.A short history ofSHELXActa Crystallographica Section A Foundations of Crystallography · 200784,500 citations
21. 21.Statistical Power Analysis for the Behavioral SciencesTechnometrics · 198983,906 citations
22. 22.“Mini-mental state”Journal of Psychiatric Research · 197582,784 citations
23. 23.Adam: A Method for Stochastic Optimization201482,703 citations
24. 24.Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 CountriesCA A Cancer Journal for Clinicians · 202179,611 citations
25. 25.Long Short-Term MemoryNeural Computation · 199779,221 citations
26. 26.Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statementBMJ · 200978,446 citations
27. 27.Case Study Research: Design and Methods198477,633 citations
28. 28.Using multivariate statistics198376,643 citations
29. 29.Standard methods: For the examination of water and waste waterAnalytical Biochemistry · 199075,426 citations
30. 30.Projector augmented-wave methodPhysical review. B, Condensed matter · 199475,346 citations
31. 31.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countriesCA A Cancer Journal for Clinicians · 201874,955 citations
32. 32.A Mathematical Theory of CommunicationBell System Technical Journal · 194873,365 citations
33. 33.Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research · 199771,835 citations
34. 34.Very Deep Convolutional Networks for Large-Scale Image RecognitionComputer Vision and Pattern Recognition · 201471,320 citations
35. 35.The Measurement of Observer Agreement for Categorical DataBiometrics · 197770,424 citations
36. 36.Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2Genome biology · 201470,421 citations
37. 37.From ultrasoft pseudopotentials to the projector augmented-wave methodPhysical review. B, Condensed matter · 199970,060 citations
38. 38.The theory of planned behaviorOrganizational Behavior and Human Decision Processes · 199170,050 citations
39. 39.DNA sequencing with chain-terminating inhibitorsProceedings of the National Academy of Sciences · 197769,181 citations
40. 40.The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations.Journal of Personality and Social Psychology · 198668,448 citations
41. 41.ImageNet Classification with Deep Convolutional Neural NetworksNeural Information Processing Systems · 201267,909 citations
42. 42.U-Net: Convolutional Networks for Biomedical Image SegmentationLecture notes in computer science · 201567,592 citations
43. 43.Fitting Linear Mixed-Effects Models Usinglme4Journal of Statistical Software · 201566,326 citations
44. 44.A Revised Medium for Rapid Growth and Bio Assays with Tobacco Tissue CulturesPhysiologia Plantarum · 196266,242 citations
45. 45.Statistical power analysis for the behavioral sciencesComputers Environment and Urban Systems · 199065,781 citations
46. 46.Deep learningNature · 201564,978 citations
47. 47.Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionAnalytical Biochemistry · 198764,270 citations
48. 48.The moderator–mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations.Journal of Personality and Social Psychology · 198664,210 citations
49. 49.CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceNucleic Acids Research · 199463,397 citations
50. 50.A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUESJournal of Biological Chemistry · 195763,238 citations

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