The Role of Caspase Cleavage of Tau in Alzheimer Disease Neuropathology

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Alzheimer's Disease: Genes, Proteins, and Therapy

2001 • 5,919 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

2003 • 3,802 citations

Neurodegenerative Tauopathies

2001 • 2,276 citations

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.

2000 • 1,878 citations

Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

1996 • 1,734 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

2001 • 1,543 citations

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

2001 • 1,469 citations

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

1994 • 1,213 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Intraneuronal Aβ42 Accumulation in Human Brain

2000 • 955 citations

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

1992 • 936 citations

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

2003 • 928 citations

Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

2001 • 889 citations

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1993 • 856 citations

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

2002 • 843 citations

Overexpression of Tau Protein Inhibits Kinesin-dependent Trafficking of Vesicles, Mitochondria, and Endoplasmic Reticulum: Implications for Alzheimer's Disease

1998 • 800 citations

Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease

2003 • 784 citations

Tau is essential to β-amyloid-induced neurotoxicity

2002 • 781 citations

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

1999 • 777 citations

Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

2004 • 760 citations

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding

1993 • 759 citations

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease.

1994 • 704 citations

Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

2002 • 679 citations

Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

1990 • 638 citations

Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia

1977 • 628 citations

Structural characterization of the core of the paired helical filament of Alzheimer disease.

1988 • 566 citations

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205

1995 • 551 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau

1997 • 517 citations

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.

1992 • 509 citations

Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau

1992 • 507 citations

Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β

2003 • 481 citations

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells

1994 • 461 citations

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

2004 • 461 citations

Intracellular accumulation of β-amyloid1–42 in neurons is facilitated by the α7 nicotinic acetylcholine receptor in Alzheimer’s disease

2002 • 442 citations

The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

1993 • 439 citations

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

2004 • 406 citations

Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome

2002 • 377 citations

Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament.

1993 • 374 citations

Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

1997 • 353 citations

Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

2000 • 346 citations

Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice

2001 • 337 citations

A nucleated assembly mechanism of Alzheimer paired helical filaments

1998 • 327 citations

Amyloid β peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures

2002 • 304 citations

Conformational change as one of the earliest alterations of tau in Alzheimer's disease

2000 • 301 citations

Active Caspase-6 and Caspase-6-Cleaved Tau in Neuropil Threads, Neuritic Plaques, and Neurofibrillary Tangles of Alzheimer's Disease

2004 • 281 citations

Hippocampal Neuron Loss Exceeds Amyloid Plaque Load in a Transgenic Mouse Model of Alzheimer's Disease

2004 • 278 citations

Caspase 3 activation is essential for neuroprotection in preconditioning

2003 • 272 citations

C‐terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase‐3β expression

2003 • 266 citations

Aggregated Amyloid-β Protein Induces Cortical Neuronal Apoptosis and Concomitant “Apoptotic” Pattern of Gene Induction

1997 • 261 citations

Activated caspase-3 expression in Alzheimer’s and aged control brain: correlation with Alzheimer pathology

2001 • 252 citations

Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease.

1998 • 248 citations

A Conformation‐ and Phosphorylation‐Dependent Antibody Recognizing the Paired Helical Filaments of Alzheimer's Disease

1997 • 247 citations

Tau Cleavage and Dephosphorylation in Cerebellar Granule Neurons Undergoing Apoptosis

1998 • 233 citations

τ in Paired Helical Filaments Is Functionally Distinct from Fetal τ: Assembly Incompetence of Paired Helical Filament‐τ

1993 • 228 citations

Intracellular Mechanisms of Amyloid Accumulation and Pathogenesis in Alzheimer's Disease

2001 • 221 citations

Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer's Disease

2004 • 211 citations

Proapoptotic Effects of Tau Cleavage Product Generated by Caspase-3

2001 • 206 citations

Glycogen synthase kinase-3β phosphorylates tau protein at multiple sites in intact cells

1995 • 205 citations

Apoptotic Cell Death Induced by β‐Amyloid_1–42 Peptide Is Cell Type Dependent

1995 • 202 citations

The Neuronal Microtubule‐Associated Protein Tau Is a Substrate for Caspase‐3 and an Effector of Apoptosis

2000 • 191 citations

Neuronal Apoptosis Induced by β-Amyloid Is Mediated by Caspase-8

1999 • 186 citations

β-Amyloid Induces Paired Helical Filament-like Tau Filaments in Tissue Culture

2003 • 172 citations

“Apoptotic” biochemical cascades in synaptic compartments: Roles in adaptive plasticity and neurodegenerative disorders

1999 • 168 citations

Correlation between Caspase Activation and Neurofibrillary Tangle Formation in Alzheimer’s Disease

2001 • 167 citations

Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization.

1997 • 164 citations

Tau Phosphorylation at Serine 396 and Serine 404 by Human Recombinant Tau Protein Kinase II Inhibits Tau's Ability to Promote Microtubule Assembly

2000 • 145 citations

Oxidative Regulation of Fatty Acid-Induced Tau Polymerization

2000 • 138 citations

Nonsaturable Binding Indicates Clustering of Tau on the Microtubule Surface in a Paired Helical Filament-like Conformation

2000 • 133 citations

Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins).

1992 • 113 citations

Cleavage of Atrophin-1 at Caspase Site Aspartic Acid 109 Modulates Cytotoxicity

1999 • 108 citations

Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors

2004 • 103 citations

Caspase activation in the limbic cortex of subjects with early Alzheimer's disease

2003 • 99 citations

Multiple Pathways of Apoptosis in PC12 Cells

1999 • 93 citations

Amyloid‐β‐induced toxicity of primary neurons is dependent upon differentiation‐associated increases in tau and cyclin‐dependent kinase 5 expression

2003 • 83 citations

Consistent immunohistochemical detection of intracellular β-amyloid42 in pyramidal neurons of Alzheimer's disease entorhinal cortex

2002 • 75 citations

Intracellular A-Beta Amyloid, A Sign for Worse Things to Come?

2002 • 74 citations

New Leads on the 'How' of Alzheimer's

2001 • 66 citations

Lipofuscin and Aβ42 exhibit distinct distribution patterns in normal and Alzheimer's disease brains

2002 • 52 citations

X‐Linked inhibitor of apoptosis protein is involved in mutant SOD1‐mediated neuronal degeneration

2002 • 49 citations

Formation of diffuse and fibrillar tangles in aging and early Alzheimer’s disease☆

2000 • 47 citations

The Microtubule Binding of Tau and High Molecular Weight Tau in Apoptotic PC12 Cells Is Impaired because of Altered Phosphorylation

1999 • 41 citations

Transient oxidative stress in SH‐SY5Y human neuroblastoma cells results in caspase dependent and independent cell death and tau proteolysis

2000 • 36 citations

Transient oxidative stress in SH-SY5Y human neuroblastoma cells results in caspase dependent and independent cell death and tau proteolysis

2000 • 29 citations